Bocaparvovirus (taxid:1507401)

VIRION

image

Non-enveloped, round, T=1 icosahedral symmetry, 21-22 nm in diameter. The capsid consists of 60 copies of CP protein.
image

GENOME

image

Linear, ssDNA genome of about 5.5kb in size. Negative strands are predominantly encapsidated. ORFs for both the structural and non-structural proteins are located on the same DNA strand.
The genome is replicated through rolling-hairpin mechanism.

GENE EXPRESSION

Host proteins transcribe the genomes into mRNAs. Alternative mRNAs splicing allows expression of at least eight different mRNAs. VP2 is translated by leaky scanning from VP1 gene, VP3 would be produced by cleavage of VP2.

ENZYMES

REPLICATION

NUCLEAR

  1. Attachement to host receptors initiates clathrin-mediated endocytosis of the virion into the host cell.
  2. The virion penetrates into the cytoplasm via permeabilization of host endosomal membrane.
  3. Microtubular transport of the virion toward the nucleus.
  4. The viral ssDNA genome penetrates into the nucleus.
  5. The ssDNA is converted into dsDNA by cellular proteins.
  6. dsDNA transcription gives rise to viral mRNAs when host cell enters S phase and translated to produce viral proteins.
  7. Replication occurs through rolling-hairpin mechanism, with NS1 endonuclease binding covalently to the 5' genomic end.
  8. Individual ssDNA genomes are excised from replication concatemers by a process called junction resolution.
  9. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated to form new virions that are released by cell lysis.

Host-virus interaction

Apoptosis modulation

Minute virus of canines (MVC) induces apoptosis and caspases activation

Cell-cycle modulation

MVC induces G2/M checkpoint arrest.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

15 entries grouped by protein

5 entries

Minor capsid protein VP1 (EC 3.1.1.4)

Select_allDeselect_all
CAPSD_HBOC1
Primate bocaparvovirus 1 (strain Human bocavirus 1 type 1) (HBoV1) (Human bocavirus type 1) reference strain
CAPSD_PAVBP
Bovine parvovirus 1 (BPV-1) reference strain
CAPSD_HBOC2
Human bocavirus 2 (HBoV2) (Human bocavirus type 2)
CAPSD_HBOC3
Human bocavirus 3 (HBoV3) (Adelavirus W471)
CAPSD_HBOC4
Human bocavirus 4 (HBoV4) (Human bocavirus type 4)

5 entries

Non-structural protein NP-1 (NP1)

Select_allDeselect_all
NP1_HBOC1
Primate bocaparvovirus 1 (strain Human bocavirus 1 type 1) (HBoV1) (Human bocavirus type 1) reference strain
NP1_PAVBP
Bovine parvovirus 1 (BPV-1) reference strain
NP1_HBOC2
Human bocavirus 2 (HBoV2) (Human bocavirus type 2)
NP1_HBOC3
Human bocavirus 3 (HBoV3) (Adelavirus W471)
NP1_HBOC4
Human bocavirus 4 (HBoV4) (Human bocavirus type 4)

5 entries

Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural protein NS1)

Select_allDeselect_all
NS1_HBOC1
Primate bocaparvovirus 1 (strain Human bocavirus 1 type 1) (HBoV1) (Human bocavirus type 1) reference strain
NS1_PAVBP
Bovine parvovirus 1 (BPV-1) reference strain
NS1_HBOC2
Human bocavirus 2 (HBoV2) (Human bocavirus type 2)
NS1_HBOC3
Human bocavirus 3 (HBoV3) (Adelavirus W471)
NS1_HBOC4
Human bocavirus 4 (HBoV4) (Human bocavirus type 4)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Bat bocavirus taxid:1329649

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07352
Non-structural protein 1 ma-jd-viral-23439
Non-structural protein NP-1 ma-jd-viral-43847
VP2 protein ma-jd-viral-07317

Bocavirus gorilla/GBoV1/2009 taxid:864686

Protein ModelArchive
Capsid protein ma-jd-viral-07324
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07278
Non-structural protein 1 ma-jd-viral-23420
Non-structural protein NP-1 ma-jd-viral-43833

Canine bocavirus 1 taxid:1511885

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07297
Non-structural protein 1 ma-jd-viral-23418
Non-structural protein NP-1 ma-jd-viral-43845
VP2 ma-jd-viral-07350

Feline bocaparvovirus 2 taxid:1417756

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07345
Non-structural protein 1 ma-jd-viral-23424
Non-structural protein NP-1 ma-jd-viral-43849
VP2 ma-jd-viral-07336

Feline bocavirus taxid:1174530

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07355
Non-structural protein 1 ma-jd-viral-23433
Non-structural protein NP-1 ma-jd-viral-43827
VP2 ma-jd-viral-07295

Human bocavirus 2 taxid:573977

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07304
Non-structural protein NP-1 (NP1) ma-jd-viral-43832

Human bocavirus 3 taxid:638313

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07279
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07327
Non-structural protein NP-1 (NP1) ma-jd-viral-43850

Human bocavirus 4 taxid:1511883

Protein ModelArchive
Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural protein... ma-jd-viral-23413
Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural protein... ma-jd-viral-23444
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07319
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07335
Non-structural protein NP-1 (NP1) ma-jd-viral-43829

Porcine bocavirus taxid:1165907

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07310
Non-structural protein 1 ma-jd-viral-23445
Non-structural protein NP-1 ma-jd-viral-43843
VP2 ma-jd-viral-07354

Porcine bocavirus 1 pig/ZJD/China/2006 taxid:795694

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07305
Non-structural protein 1 ma-jd-viral-23429
Non-structural protein NP-1 ma-jd-viral-43822
VP2 ma-jd-viral-07289

Porcine bocavirus 3 taxid:1084715

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07330
Non-structural protein 1 ma-jd-viral-23414
Non-structural protein NP-1 ma-jd-viral-43835
VP2 ma-jd-viral-07293

Porcine bocavirus 4-1 taxid:1084717

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07349
Non-structural protein 1 ma-jd-viral-23436
Non-structural protein NP-1 ma-jd-viral-43841
VP2 ma-jd-viral-07307

Porcine bocavirus 5/JS677 taxid:1131622

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07340
Non-structural protein 1 ma-jd-viral-23447
Non-structural protein NP-1 ma-jd-viral-43840
VP2 ma-jd-viral-07321

Rat bocavirus taxid:1788315

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07301
Non-structural protein 1 ma-jd-viral-23412
Non-structural protein 1 ma-jd-viral-23442
Non-structural protein NP-1 ma-jd-viral-43830
VP2 ma-jd-viral-07342

Rhinolophus sinicus bocaparvovirus taxid:1911555

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07353
Non-structural protein 1 ma-jd-viral-23410
Non-structural protein 1 ma-jd-viral-23426
Non-structural protein NP-1 ma-jd-viral-43828
VP2 ma-jd-viral-07309

bovine bocaparvovirus 2 taxid:1864484

Protein ModelArchive
Minor capsid protein VP1 (EC 3.1.1.4) ma-jd-viral-07290
Non-structural protein 1 ma-jd-viral-23431