Iteradensovirus (taxid:40122)

VIRION

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Non-enveloped, round, T=1 icosahedral symmetry, 21-22 nm in diameter. The capsid consists of 60 copies of CP protein.
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GENOME

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Linear, ssDNA genome of about 5kb in size, with long inverted terminal repeats. Equal amount of positive and negative strands are encapsidated, although the percentage of particles encapsidating the positive strand can be lower depending on the host cell. ORFs for both the structural and non-structural proteins are located on the same DNA strand. In some species, there is a small ORF on the complementary DNA strand that might be non coding.
The genome is replicated through rolling-hairpin mechanism.

GENE EXPRESSION

Host proteins transcribe the genomes into mRNAs.

ENZYMES

REPLICATION

NUCLEAR

  1. Attachement to host receptors initiates clathrin-mediated endocytosis of the virion into the host cell.
  2. The virion penetrates into the cytoplasm via permeabilization of host endosomal membrane.
  3. Microtubular transport of the virion toward the nucleus.
  4. The viral ssDNA genome penetrates into the nucleus.
  5. The ssDNA is converted into dsDNA by cellular proteins.
  6. dsDNA transcription gives rise to viral mRNAs when host cell enters S phase and translated to produce viral proteins.
  7. Replication occurs through rolling-hairpin mechanism, with NS1 endonuclease binding covalently to the 5' genomic end.
  8. Individual ssDNA genomes are excised from replication concatemers by a process called junction resolution.
  9. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated to form new virions that are released by cell lysis.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

3 entries grouped by protein

1 entry

Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural protein NS1)

NS1_BMDNV
Bombyx mori densovirus (BmDNV) (Bombyx densonucleosis virus)

1 entry

Putative non-structural protein (ORF1)

VNS1_BMDNV
Bombyx mori densovirus (BmDNV) (Bombyx densonucleosis virus)

1 entry

Putative non-structural protein (ORF3)

VNS3_BMDNV
Bombyx mori densovirus (BmDNV) (Bombyx densonucleosis virus)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Bombyx mori densovirus 5 (isolate Shinshu) taxid:648251

Protein ModelArchive
Nonstructural protein ma-jd-viral-50375
Nonstructural protein ma-jd-viral-48527
Nonstructural protein ma-jd-viral-40765

Danaus plexippus plexippus iteravirus taxid:1469956

Protein ModelArchive
Nonstructural protein NS1 ma-jd-viral-48526
Nonstructural protein NS2 ma-jd-viral-50376
Structural protein VP ma-jd-viral-66425

Helicoverpa armigera densovirus taxid:1045778

Protein ModelArchive
NS1 ma-jd-viral-48528
NS2 ma-jd-viral-41668
VP ma-jd-viral-66426