Kolmioviridae (taxid:2842321)

Satellite virus: infection requires host cell to be co-infected with helper virus

VIRION

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Enveloped, spherical about 22 nm in diameter. The virion is covered by helper virus membrane proteins.

GENOME

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Circular, ssRNA(-) genome of 1,68 kb. Most of the genome displays complementary strands. Replication occurs by rolling circle, single genome being cleaved/ligated by ribozymes.

GENE EXPRESSION

Encodes for one protein. in Deltavirus, genome editing by host ADAR1 extends the S-HDAg ORF by 19 amino acids, inducing production of L-HDAg. Edited genome seems to be unable to replicate.

REPLICATION

NUCLEAR

  1. Virion attaches to host receptors though helper virus surface protein.
  2. Fusion of virus membrane with the vesicle membrane; the RNA genome is released in the cytoplasm and migrates to the nucleus.
  3. Transcription of the single viral gene, promoting viral transcription and replication
  4. Symmetrical rolling circle replication by host DNA-dependent RNA polymerase II
  5. later, genomic RNA can be edited by host ADAR1, inducing packaging of viral genome at the RE.
  6. Budding by helper viral proteins.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

35 entries grouped by protein

17 entries

Large delta antigen (L-HDAg) (p27)

Select_allDeselect_all
LHDAG_HDVD3
Hepatitis delta virus genotype I (isolate D380) (HDV) reference strain
LHDAG_HDV83
Hepatitis delta virus genotype II (isolate 7/18/83) (HDV)
LHDAG_HDVAM
Hepatitis delta virus genotype I (isolate American) (HDV)
LHDAG_HDVIT
Hepatitis delta virus genotype I (isolate Italian) (HDV)
LHDAG_HDVL1
Hepatitis delta virus genotype I (isolate Lebanon-1) (HDV)
LHDAG_HDVM1
Hepatitis delta virus genotype I (isolate Japanese M-1) (HDV)
LHDAG_HDVM2
Hepatitis delta virus genotype I (isolate Japanese M-2) (HDV)
LHDAG_HDVNA
Hepatitis delta virus genotype I (isolate Nauru) (HDV)
LHDAG_HDVP1
Hepatitis delta virus genotype III (isolate Peru-1) (HDV)
LHDAG_HDVS1
Hepatitis delta virus genotype II (isolate Japanese S-1) (HDV)
LHDAG_HDVS2
Hepatitis delta virus genotype I (isolate Japanese S-2) (HDV)
LHDAG_HDVTW
Hepatitis delta virus genotype II (isolate TW2476) (HDV)
LHDAG_HDVU2
Hepatitis delta virus genotype I (isolate US-2) (HDV)
LHDAG_HDVV1
Hepatitis delta virus genotype III (isolate VnzD8624) (HDV)
LHDAG_HDVV2
Hepatitis delta virus genotype III (isolate VnzD8349) (HDV)
LHDAG_HDVV3
Hepatitis delta virus genotype III (isolate VnzD8375) (HDV)
LHDAG_HDVWO
Hepatitis delta virus genotype I (isolate Woodchuck) (HDV)

18 entries

Small delta antigen (S-HDAg) (p24)

Select_allDeselect_all
SHDAG_HDVD3
Hepatitis delta virus genotype I (isolate D380) (HDV) reference strain
SHDAG_HDV27
Hepatitis delta virus genotype I (isolate HDV/Human/Central African Republic/FH27/1985) (HDV)
SHDAG_HDV83
Hepatitis delta virus genotype II (isolate 7/18/83) (HDV)
SHDAG_HDVAM
Hepatitis delta virus genotype I (isolate American) (HDV)
SHDAG_HDVIT
Hepatitis delta virus genotype I (isolate Italian) (HDV)
SHDAG_HDVL1
Hepatitis delta virus genotype I (isolate Lebanon-1) (HDV)
SHDAG_HDVM1
Hepatitis delta virus genotype I (isolate Japanese M-1) (HDV)
SHDAG_HDVM2
Hepatitis delta virus genotype I (isolate Japanese M-2) (HDV)
SHDAG_HDVNA
Hepatitis delta virus genotype I (isolate Nauru) (HDV)
SHDAG_HDVP1
Hepatitis delta virus genotype III (isolate Peru-1) (HDV)
SHDAG_HDVS1
Hepatitis delta virus genotype II (isolate Japanese S-1) (HDV)
SHDAG_HDVS2
Hepatitis delta virus genotype I (isolate Japanese S-2) (HDV)
SHDAG_HDVTW
Hepatitis delta virus genotype II (isolate TW2476) (HDV)
SHDAG_HDVU2
Hepatitis delta virus genotype I (isolate US-2) (HDV)
SHDAG_HDVV1
Hepatitis delta virus genotype III (isolate VnzD8624) (HDV)
SHDAG_HDVV2
Hepatitis delta virus genotype III (isolate VnzD8349) (HDV)
SHDAG_HDVV3
Hepatitis delta virus genotype III (isolate VnzD8375) (HDV)
SHDAG_HDVWO
Hepatitis delta virus genotype I (isolate Woodchuck) (HDV)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Hepatitis delta virus genotype I (isolate D380) taxid:31762

Protein ModelArchive
Small delta antigen (S-HDAg) (p24) ma-jd-viral-63568