Pneumoviridae (taxid:11244)

VIRION

image

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

image

Negative-stranded RNA linear genome, about 13-15 kb in size. Encodes for 8 to 11 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The NS2 protein plays a role in inhibition of RIG-I antiviral signaling

The NS1 protein plays a role in inhibition of MAVS antiviral signaling

Activation of host NF-kappa-B

The HRSV M2-1 can activate NF-kappa-B signaling through interaction with host RELA.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

116 entries grouped by protein

12 entries

Fusion glycoprotein F0

Select_allDeselect_all
FUS_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
FUS_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
FUS_BRSVC
Bovine respiratory syncytial virus (strain Copenhagen) (BRS)
FUS_BRSVR
Bovine respiratory syncytial virus (strain Rb94) (BRS)
FUS_HRSV
Human respiratory syncytial virus
FUS_HRSV1
Human respiratory syncytial virus B (strain 18537)
FUS_HRSVR
Human respiratory syncytial virus A (strain RSS-2)
FUS_TRTV
Turkey rhinotracheitis virus (TRTV)

23 entries

Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

Select_allDeselect_all
GLYC_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
GLYC_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
GLYC_BRSV1
Bovine respiratory syncytial virus (strain 127) (BRS)
GLYC_BRSV2
Bovine respiratory syncytial virus (strain 220-60) (BRS)
GLYC_BRSV4
Bovine respiratory syncytial virus (strain 4642) (BRS)
GLYC_BRSV7
Bovine respiratory syncytial virus (strain 375) (BRS)
GLYC_BRSV9
Bovine respiratory syncytial virus (strain 220-69) (BRS)
GLYC_BRSVC
Bovine respiratory syncytial virus (strain Copenhagen) (BRS)
GLYC_BRSVL
Bovine respiratory syncytial virus (strain Lelystad) (BRS)
GLYC_BRSVR
Bovine respiratory syncytial virus (strain Rb94) (BRS)
GLYC_BRSVS
Bovine respiratory syncytial virus (strain Snook) (BRS)
GLYC_BRSVW
Bovine respiratory syncytial virus (strain Wbh) (BRS)
GLYC_HRSV
Human respiratory syncytial virus
GLYC_HRSV1
Human respiratory syncytial virus B (strain 18537)
GLYC_HRSV2
Human respiratory syncytial virus A (strain rsb642)
GLYC_HRSV3
Human respiratory syncytial virus A (strain rsb1734)
GLYC_HRSV4
Human respiratory syncytial virus A (strain rsb5857)
GLYC_HRSV5
Human respiratory syncytial virus A (strain rsb6190)
GLYC_HRSV6
Human respiratory syncytial virus A (strain rsb6256)
GLYC_HRSV7
Human respiratory syncytial virus A (strain rsb6614)
GLYC_HRSV8
Human respiratory syncytial virus B (strain 8/60)

Major surface glycoprotein G (Attachment glycoprotein G)

GLYC_HRSVA
Human respiratory syncytial virus A (strain A2)
GLYC_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

Major surface glycoprotein G (Attachment glycoprotein G)

7 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
L_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
L_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
L_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
L_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
L_HRSV
Human respiratory syncytial virus
L_HRSVA
Human respiratory syncytial virus A (strain A2)

9 entries

Protein M2-1 (Envelope-associated 22 kDa protein)

Select_allDeselect_all
M21_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
M21_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)

M21_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
M21_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain

Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)

M21_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain

Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)

M21_HRSV
Human respiratory syncytial virus

Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1) (Vp24)

M21_HRSVA
Human respiratory syncytial virus A (strain A2)

Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1) (Vp24)

M21_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)
M21_TRTV
Turkey rhinotracheitis virus (TRTV)

6 entries

Protein M2-2

Select_allDeselect_all
M22_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
M22_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
M22_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
M22_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
M22_HRSV
Human respiratory syncytial virus
M22_HRSVA
Human respiratory syncytial virus A (strain A2)

9 entries

Matrix protein (M protein)

Select_allDeselect_all
MATRX_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
MATRX_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
MATRX_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
MATRX_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
MATRX_HRSS2
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)
MATRX_HRSV
Human respiratory syncytial virus
MATRX_HRSVA
Human respiratory syncytial virus A (strain A2)
MATRX_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)
MATRX_TRTV
Turkey rhinotracheitis virus (TRTV)

1 entry

Matrix protein

MTRX_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

11 entries

Nucleoprotein (Protein N) (Nucleocapsid protein)

Select_allDeselect_all
NCAP_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
NCAP_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NCAP_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
NCAP_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NCAP_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain

Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

NCAP_BRSV3
Bovine respiratory syncytial virus (strain 391-2) (BRS)
NCAP_BRSVR
Bovine respiratory syncytial virus (strain Rb94) (BRS)
NCAP_HRSV
Human respiratory syncytial virus
NCAP_HRSV1
Human respiratory syncytial virus B (strain 18537)
NCAP_HRSVA
Human respiratory syncytial virus A (strain A2)
NCAP_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

8 entries

Non-structural protein 1 (Non-structural protein 1C)

Select_allDeselect_all
NS1_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NS1_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NS1_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
NS1_HRSS2
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSV
Human respiratory syncytial virus
NS1_HRSV1
Human respiratory syncytial virus B (strain 18537)
NS1_HRSVA
Human respiratory syncytial virus A (strain A2)

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

7 entries

Non-structural protein 2 (NS2) (Non-structural protein 1B)

Select_allDeselect_all
NS2_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NS2_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NS2_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
NS2_HRSV
Human respiratory syncytial virus
NS2_HRSV1
Human respiratory syncytial virus B (strain 18537)
NS2_HRSVA
Human respiratory syncytial virus A (strain A2)
NS2_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

9 entries

Phosphoprotein (Protein P)

Select_allDeselect_all
PHOSP_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

Phosphoprotein

PHOSP_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
PHOSP_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
PHOSP_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
PHOSP_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
PHOSP_HRSV
Human respiratory syncytial virus
PHOSP_HRSV1
Human respiratory syncytial virus B (strain 18537)
PHOSP_HRSVA
Human respiratory syncytial virus A (strain A2)
PHOSP_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

11 entries

Small hydrophobic protein (Small protein 1A)

Select_allDeselect_all
SH_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

Small hydrophobic protein

SH_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
SH_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Small hydrophobic protein

SH_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
SH_BRSV3
Bovine respiratory syncytial virus (strain 391-2) (BRS)
SH_HRSS2
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)
SH_HRSV
Human respiratory syncytial virus
SH_HRSV1
Human respiratory syncytial virus B (strain 18537)
SH_HRSV8
Human respiratory syncytial virus B (strain 8/60)
SH_HRSVA
Human respiratory syncytial virus A (strain A2)
SH_TRTV
Turkey rhinotracheitis virus (TRTV)

Small hydrophobic protein

3 entries

Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

Select_allDeselect_all
VGLG_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
VGLG_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
VGLG_TRTV
Turkey rhinotracheitis virus (TRTV)

Major surface glycoprotein G (Attachment glycoprotein G)

These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Canine pneumovirus taxid:1408279

Protein ModelArchive
Matrix protein M2-2 ma-jd-viral-61345
Protein M2-1 ma-jd-viral-32281

Human respiratory syncytial virus taxid:11250

Protein ModelArchive
Fusion glycoprotein F0 ma-jd-viral-42968
Matrix protein (M protein) ma-jd-viral-03354
Non-structural protein 1 (Non-structural protein 1C) ma-jd-viral-40536
Non-structural protein 2 (Non-structural protein 1B) ma-jd-viral-50993
Nucleoprotein ma-jd-viral-52617
Phosphoprotein ma-jd-viral-35127
Protein M2-1 ma-jd-viral-32282
Small hydrophobic protein (Small protein 1A) ma-jd-viral-51897
Transcription-replication factor M2-2 ma-jd-viral-32316

Human respiratory syncytial virus B (strain B1) taxid:79692

Protein ModelArchive
Fusion glycoprotein F0 (Protein F) ma-jd-viral-42968
Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein)... ma-jd-viral-54372
Matrix protein (M protein) ma-jd-viral-03354
Non-structural protein 1 (Non-structural protein 1C) ma-jd-viral-40536
Non-structural protein 2 (NS2) (Non-structural protein 1B) ma-jd-viral-50993
Nucleoprotein (Protein N) (Nucleocapsid protein) ma-jd-viral-52617
Phosphoprotein (Protein P) ma-jd-viral-35127
Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor... ma-jd-viral-32282
Protein M2-2 ma-jd-viral-32316
Small hydrophobic protein (Small protein 1A) ma-jd-viral-51897

Pneumonia virus of mice J3666 taxid:270473

Protein ModelArchive
Attachment protein ma-jd-viral-33782
Fusion glycoprotein F0 ma-jd-viral-42981
M2-2 ma-jd-viral-61346
Matrix protein (M protein) ma-jd-viral-03353
NS1 protein (Non-structural protein 1) ma-jd-viral-58037
NS2 protein (Non-structural protein 2) ma-jd-viral-30918
Nucleoprotein ma-jd-viral-52618
Phosphoprotein ma-jd-viral-35128
Protein M2-1 ma-jd-viral-32283
Small hydrophobic protein ma-jd-viral-52217
p2 ma-jd-viral-39714