Microviridae

VIRION

Non-enveloped, round, T=1 icosahedral symmetry, about 30 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentomers. The virion is composed of 60 copies each of the F, G, and J proteins, and 12 copies of the H protein. There are 12 spikes which are each composed of 5 G and one H proteins.


GENOME

Circular, ssDNA(+) genome of 4.4 to 6.1kb. replication occurs via dsDNA intermediate and rolling circle.

GENE EXPRESSION

Early and late genes promoters tightly regulate the timing of gene expression, which is crucial for the replication cycle.

REPLICATION

CYTOPLASMIC

  1. Pilus-mediated adsorption of the virus onto host cell
  2. The proteins of the capsid perform Injection of the viral DNA through bacterial membranes into cell cytoplasm.
  3. Host polymerase convert the (+)ssDNA viral genome into a covalently closed dsDNA called replicative form DNA I (RF-I).
  4. Early viral genes are transcribed by host RNA polymerase, producing viral replication proteins.
  5. Viral protein A cleaves RF-I(+) DNA strand at the origin of replication and covalently attaches itself to the DNA.
  6. (+)strand replication occurs by rolling circle, which is converted to dsDNA by host polymerase, generating RF-II molecules (amplification of RF-I).
  7. Late viral genes are transcribed by host RNA polymerase.
  8. Procapsid assembly in the cytoplasm.
  9. Viral protein C binds to replication complex, inducing synthesis and packaging of neo-synthesized (+)ssDNA genomes (RF-III) into procapsids.
  10. Procapsids maturation occurs in host cytoplasm
  11. Mature virions are released from the cell by lysis.

Matching UniProtKB/Swiss-Prot entries

78 entries grouped by protein (browse by keywords)

3 entries

Internal scaffolding protein ORF3

Select_allDeselect_all
B_BPCHP
Chlamydia phage 1 (Bacteriophage Chp1) reference strain

Internal scaffolding protein VP3 (Protein VP3) (VP3)

B_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain

Internal scaffolding protein VP3

B_SPV4
Spiroplasma virus 4 (SpV4) reference strain

4 entries

Protein ORF5

Select_allDeselect_all
C_BPCHP
Chlamydia phage 1 (Bacteriophage Chp1) reference strain
C_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain

Protein VP5

C_BPPHS
Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain

Protein C

C_SPV4
Spiroplasma virus 4 (SpV4) reference strain

4 entries

Capsid protein VP1 (VP1)

Select_allDeselect_all
CAPSD_BPCHP
Chlamydia phage 1 (Bacteriophage Chp1) reference strain

Capsid protein VP1 (Protein VP1) (VP1)

CAPSD_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain
CAPSD_BPPHS
Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain

Capsid protein F (F protein) (GPF)

CAPSD_SPV4
Spiroplasma virus 4 (SpV4) reference strain

1 entry

Lysis protein E (Protein E) (GPE)

E_BPPHS
Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain

5 entries

Major spike protein G (G protein) (GPG)

Select_allDeselect_all
G_BPAL3
Enterobacteria phage alpha3 (Bacteriophage alpha-3) reference strain
G_BPG4
Enterobacteria phage G4 (Bacteriophage G4) reference strain
G_BPPHS
Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain
G_BPPHK
Enterobacteria phage phiK (Bacteriophage phi-K)
G_BPS13
Enterobacteria phage S13 (Bacteriophage S13)

4 entries

Minor spike protein H (H protein) (Pilot protein)

Select_allDeselect_all
H_BPCHP
Chlamydia phage 1 (Bacteriophage Chp1) reference strain

Minor spike protein H (H protein) (Pilot protein) (Protein VP2) (VP2)

H_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain

Minor spike protein H (H protein) (Pilot protein) (Protein VP2) (VP2)

H_BPPHS
Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain
H_SPV4
Spiroplasma virus 4 (SpV4) reference strain

7 entries

DNA-binding protein J (J protein) (Small core protein)

Select_allDeselect_all
J_BPAL3
Enterobacteria phage alpha3 (Bacteriophage alpha-3) reference strain
J_BPCHP
Chlamydia phage 1 (Bacteriophage Chp1) reference strain

DNA binding protein ORF8

J_BPG4
Enterobacteria phage G4 (Bacteriophage G4) reference strain
J_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain

DNA binding protein VP8

J_BPPHS
Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain
J_SPV4
Spiroplasma virus 4 (SpV4) reference strain

DNA binding protein ORF8

J_BPPHK
Enterobacteria phage phiK (Bacteriophage phi-K)

1 entry

Protein K

K_BPPHS
Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain

1 entry

Uncharacterized protein N

N_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain

2 entries

Uncharacterized protein ORF6

Select_allDeselect_all
ORF6_BPCHP
Chlamydia phage 1 (Bacteriophage Chp1) reference strain
ORF6_SPV4
Spiroplasma virus 4 (SpV4) reference strain

2 entries

Uncharacterized protein ORF7

Select_allDeselect_all
ORF7_BPCHP
Chlamydia phage 1 (Bacteriophage Chp1) reference strain
ORF7_SPV4
Spiroplasma virus 4 (SpV4) reference strain

1 entry

Uncharacterized protein ORF9

ORF9_SPV4
Spiroplasma virus 4 (SpV4) reference strain

3 entries

Replication-associated protein ORF2 (EC 3.1.21.-) (EC 6.5.1.1) (Rep)

Select_allDeselect_all
REP_BPCHP
Chlamydia phage 1 (Bacteriophage Chp1) reference strain

Replication-associated protein ORF4 (EC 3.1.21.-) (EC 6.5.1.1) (Rep)

REP_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain

Replication-associated protein VP4 (Rep) (VP4) (EC 3.1.21.-) (EC 6.5.1.1)

REP_SPV4
Spiroplasma virus 4 (SpV4) reference strain

1 entry

Replication-associated protein A (EC 3.1.21.-) (EC 6.5.1.1) (RepA)

REPA_BPPHS
Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain

5 entries

Internal scaffolding protein B (Scaffolding protein B) (GPB)

Select_allDeselect_all
SCAFB_BPAL3
Enterobacteria phage alpha3 (Bacteriophage alpha-3) reference strain
SCAFB_BPG4
Enterobacteria phage G4 (Bacteriophage G4) reference strain
SCAFB_BPPHS
Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain
SCAFB_BPPHK
Enterobacteria phage phiK (Bacteriophage phi-K)
SCAFB_BPS13
Enterobacteria phage S13 (Bacteriophage S13)

5 entries

External scaffolding protein D (Scaffolding protein D) (GPD)

Select_allDeselect_all
SCAFD_BPAL3
Enterobacteria phage alpha3 (Bacteriophage alpha-3) reference strain
SCAFD_BPG4
Enterobacteria phage G4 (Bacteriophage G4) reference strain
SCAFD_BPPHS
Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain
SCAFD_BPPHK
Enterobacteria phage phiK (Bacteriophage phi-K)
SCAFD_BPS13
Enterobacteria phage S13 (Bacteriophage S13)

4 entries

A protein (GPA)

Select_allDeselect_all
VGA_BPAL3
Enterobacteria phage alpha3 (Bacteriophage alpha-3) reference strain
VGA_BPG4
Enterobacteria phage G4 (Bacteriophage G4) reference strain
VGA_BPPHK
Enterobacteria phage phiK (Bacteriophage phi-K)
VGA_BPS13
Enterobacteria phage S13 (Bacteriophage S13)

A' protein (GPA)

4 entries

C protein

Select_allDeselect_all
VGC_BPAL3
Enterobacteria phage alpha3 (Bacteriophage alpha-3) reference strain
VGC_BPG4
Enterobacteria phage G4 (Bacteriophage G4) reference strain
VGC_BPPHK
Enterobacteria phage phiK (Bacteriophage phi-K)
VGC_BPS13
Enterobacteria phage S13 (Bacteriophage S13)

4 entries

Lysis protein (E protein) (GPE)

Select_allDeselect_all
VGE_BPAL3
Enterobacteria phage alpha3 (Bacteriophage alpha-3) reference strain
VGE_BPG4
Enterobacteria phage G4 (Bacteriophage G4) reference strain
VGE_BPPHK
Enterobacteria phage phiK (Bacteriophage phi-K)
VGE_BPS13
Enterobacteria phage S13 (Bacteriophage S13)

4 entries

Capsid protein (F protein) (GPF)

Select_allDeselect_all
VGF_BPAL3
Enterobacteria phage alpha3 (Bacteriophage alpha-3) reference strain
VGF_BPG4
Enterobacteria phage G4 (Bacteriophage G4) reference strain
VGF_BPPHK
Enterobacteria phage phiK (Bacteriophage phi-K)
VGF_BPS13
Enterobacteria phage S13 (Bacteriophage S13)

4 entries

Minor spike protein (H protein) (Pilot protein)

Select_allDeselect_all
VGH_BPAL3
Enterobacteria phage alpha3 (Bacteriophage alpha-3) reference strain
VGH_BPG4
Enterobacteria phage G4 (Bacteriophage G4) reference strain
VGH_BPPHK
Enterobacteria phage phiK (Bacteriophage phi-K)
VGH_BPS13
Enterobacteria phage S13 (Bacteriophage S13)

1 entry

Small core protein (J protein)

VGJ_BPS13
Enterobacteria phage S13 (Bacteriophage S13)

4 entries

K protein

Select_allDeselect_all
VGK_BPAL3
Enterobacteria phage alpha3 (Bacteriophage alpha-3) reference strain
VGK_BPG4
Enterobacteria phage G4 (Bacteriophage G4) reference strain
VGK_BPPHK
Enterobacteria phage phiK (Bacteriophage phi-K)
VGK_BPS13
Enterobacteria phage S13 (Bacteriophage S13)

1 entry

Uncharacterized protein W

W_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain

1 entry

Uncharacterized protein X

X_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain

1 entry

Uncharacterized protein Y

Y_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain

1 entry

Uncharacterized protein Z

Z_BPPHM
Bdellovibrio phage phiMH2K (Bacteriophage phiMH2K) reference strain