Alphatetraviridae

VIRION

Non enveloped virion, about 40 nm in diameter with a T=4 icosahedral symmetry (240 copies of two proteins derived from the capsid precursor cleavage).

GENOME

Monopartite (Betatetravirus) or bipartite (Omegatetravirus) linear ssRNA(+) genome of about 6.5 kb. The 5' terminus is capped in Omegatetraviruses but not in Betatetraviruses. The 3' terminus is not polyadenylated but terminates with a distinctive tRNA-like structure.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Genomic RNA is translated into a polyprotein which is cleaved presumably by a viral protease into replication proteins. Replication produces a subgenomic RNA which encodes for capsid protein.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Genomic RNA is translated to produce replication proteins.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the subgenomic RNA encoding the capsid protein.
  7. Assembly of new virus particles.

Matching UniProtKB/Swiss-Prot entries

5 entries grouped by protein (browse by keywords)

2 entries

Capsid protein (CP) (Coat protein)

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CAPSD_HASV
Helicoverpa armigera stunt virus (HaSV) reference strain
CAPSD_NCBVS
Nudaurelia capensis beta virus (isolate Pine emperor moth/South Africa) (NbetaV) reference strain

1 entry

Protein p17

P17_HASV
Helicoverpa armigera stunt virus (HaSV) reference strain

2 entries

Methyltransferase/helicase/RNA-directed RNA polymerase (EC 2.1.1.-) (EC 2.7.7.48) (EC 3.6.4.13)

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RDRP_HASV
Helicoverpa armigera stunt virus (HaSV) reference strain
RDRP_NCBVS
Nudaurelia capensis beta virus (isolate Pine emperor moth/South Africa) (NbetaV) reference strain