H5N1 subtype

VIRION

Molecular biology

Enveloped. Usually rounded but can be filamentous. The virions are 80-120 nm in diameter.

GENOME

Segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP). Contains 8 segments coding for 12-13 proteins depending on strains. Segments size range from 890 to 2,341nt. Genome total size is 13.5Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap cleaved from cellular mRNAS by Cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track MP and NS mRNA can be alternately spliced, giving rise to mRNA coding for M2 and NEP proteins. PB1 mRNA encode three proteins by leaky scanning: PB1, N40 and PB1-F2 . Pa-X protein is translated by ribosomal frameshift on the PA gene .

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though HA protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Host-virus interaction

Innate immune response inhibition

Influenza A virus inhibits the cascade leading to production of interferon-beta by targeting different cellular proteins. NS1 inhibits host RIG-I activation upon recognition of viral RNA, and subsequent induction of IFN-beta expression.

Host protein shutoff

NS1 induces host gene expression shutoff by inducing host mRNA suppression through polyadenlyation inhibition. The viral mRNA are not affected because their polyA tail is generated by polymerase stuttering.

Matching UniProtKB/Swiss-Prot entries

173 entries grouped by strain (browse by keywords)

All proteins are shown (view only 48 complete proteome entries)

12 entries

Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain

Select_allDeselect_all
HEMA_I96A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]
NCAP_I96A0 Nucleoprotein (Nucleocapsid protein) (Protein N)
NRAM_I96A0 Neuraminidase (EC 3.2.1.18)
NEP_I96A0 Nuclear export protein (NEP) (Non structural protein 2) (NS2)
M2_I96A0 Matrix protein 2 (Proton channel protein M2)
M1_I96A0 Matrix protein 1 (M1)
NS1_I96A0 Non-structural protein 1 (NS1) (NS1A)
PB1F2_I96A0 Protein PB1-F2
PB2_I96A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
PAX_I96A0 Protein PA-X
PA_I96A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
RDRP_I96A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

12 entries

Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)

Select_allDeselect_all
HEMA_I59A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]
NEP_I59A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NCAP_I59A0 Nucleoprotein (Nucleocapsid protein) (Protein N)
NRAM_I59A0 Neuraminidase (EC 3.2.1.18)
M2_I59A0 Matrix protein 2 (Proton channel protein M2)
M1_I59A0 Matrix protein 1 (M1)
NS1_I59A0 Non-structural protein 1 (NS1) (NS1A)
PA_I59A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
PB1F2_I59A0 Protein PB1-F2
PAX_I59A0 Protein PA-X
PB2_I59A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I59A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

12 entries

Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)

Select_allDeselect_all
HEMA_I00A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]
NCAP_I00A0 Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I00A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I00A0 Neuraminidase (EC 3.2.1.18)
M2_I00A0 Matrix protein 2 (Proton channel protein M2)
M1_I00A0 Matrix protein 1 (M1)
PAX_I00A0 Protein PA-X
NS1_I00A0 Non-structural protein 1 (NS1) (NS1A)
PB2_I00A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
PA_I00A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
PB1F2_I00A0 Protein PB1-F2
RDRP_I00A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

12 entries

Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

Select_allDeselect_all
HEMA_I97A1 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]
NCAP_I97A1 Nucleoprotein (Nucleocapsid protein) (Protein N)
M1_I97A1 Matrix protein 1 (M1)
M2_I97A1 Matrix protein 2 (Proton channel protein M2)
NRAM_I97A1 Neuraminidase (EC 3.2.1.18)
NEP_I97A1 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
PA_I97A1 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
NS1_I97A1 Non-structural protein 1 (NS1) (NS1A)
PAX_I97A1 Protein PA-X
PB1F2_I97A1 Protein PB1-F2
PB2_I97A1 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I97A1 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

11 entries

Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)

Select_allDeselect_all
NCAP_I02A6 Nucleoprotein
NEP_I02A6 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
M2_I02A6 Matrix protein 2 (Proton channel protein M2)
M1_I02A6 Matrix protein 1 (M1)
NS1_I02A6 Non-structural protein 1 (NS1) (NS1A)
NRAM_I02A6 Neuraminidase (EC 3.2.1.18)
PAX_I02A6 Protein PA-X
PB1F2_I02A6 Protein PB1-F2
PB2_I02A6 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
PA_I02A6 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
RDRP_I02A6 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

10 entries

Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)

Select_allDeselect_all
NCAP_I02A2 Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I02A2 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
M2_I02A2 Matrix protein 2 (Proton channel protein M2)
M1_I02A2 Matrix protein 1 (M1)
NS1_I02A2 Non-structural protein 1 (NS1) (NS1A)
NRAM_I02A2 Neuraminidase (EC 3.2.1.18)
PA_I02A2 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
PAX_I02A2 Protein PA-X
PB1F2_I02A2 Protein PB1-F2
RDRP_I02A2 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

10 entries

Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)

Select_allDeselect_all
NEP_I01A3 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NCAP_I01A3 Nucleoprotein
NRAM_I01A3 Neuraminidase (EC 3.2.1.18)
M2_I01A3 Matrix protein 2 (Proton channel protein M2)
M1_I01A3 Matrix protein 1 (M1)
NS1_I01A3 Non-structural protein 1 (NS1) (NS1A)
PA_I01A3 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
PAX_I01A3 Protein PA-X
PB1F2_I01A3 Protein PB1-F2
RDRP_I01A3 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

10 entries

Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)

Select_allDeselect_all
NEP_I02A5 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NCAP_I02A5 Nucleoprotein
M1_I02A5 Matrix protein 1 (M1)
M2_I02A5 Matrix protein 2 (Proton channel protein M2)
NRAM_I02A5 Neuraminidase (EC 3.2.1.18)
NS1_I02A5 Non-structural protein 1 (NS1) (NS1A)
PAX_I02A5 Protein PA-X
PA_I02A5 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
PB1F2_I02A5 Protein PB1-F2
PB2_I02A5 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

10 entries

Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)

Select_allDeselect_all
NEP_I01A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NCAP_I01A0 Nucleoprotein
M1_I01A0 Matrix protein 1 (M1)
M2_I01A0 Matrix protein 2 (Proton channel protein M2)
PAX_I01A0 Protein PA-X
PA_I01A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
NS1_I01A0 Non-structural protein 1 (NS1) (NS1A)
NRAM_I01A0 Neuraminidase (EC 3.2.1.18)
PB1F2_I01A0 Protein PB1-F2
RDRP_I01A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

10 entries

Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

Select_allDeselect_all
NCAP_I02A4 Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I02A4 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
M1_I02A4 Matrix protein 1 (M1)
M2_I02A4 Matrix protein 2 (Proton channel protein M2)
NS1_I02A4 Non-structural protein 1 (NS1) (NS1A)
PA_I02A4 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
NRAM_I02A4 Neuraminidase (EC 3.2.1.18)
PAX_I02A4 Protein PA-X
PB1F2_I02A4 Protein PB1-F2
RDRP_I02A4 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

9 entries

Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)

Select_allDeselect_all
HEMA_I97A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]
NRAM_I97A0 Neuraminidase (EC 3.2.1.18)
M2_I97A0 Matrix protein 2 (Proton channel protein M2)
M1_I97A0 Matrix protein 1 (M1)
NEP_I97A0 Nuclear export protein (NEP) (Non structural protein 2) (NS2)
NS1_I97A0 Non-structural protein 1 (NS1) (NS1A)
PAX_I97A0 Protein PA-X
PA_I97A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
RDRP_I97A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

9 entries

Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)

Select_allDeselect_all
NEP_I03A1 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NCAP_I03A1 Nucleoprotein
M1_I03A1 Matrix protein 1 (M1)
M2_I03A1 Matrix protein 2 (Proton channel protein M2)
NS1_I03A1 Non-structural protein 1 (NS1) (NS1A)
NRAM_I03A1 Neuraminidase (EC 3.2.1.18)
PB2_I03A1 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
PB1F2_I03A1 Protein PB1-F2
RDRP_I03A1 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

8 entries

Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)

Select_allDeselect_all
NEP_I02A3 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NCAP_I02A3 Nucleoprotein (Nucleocapsid protein) (Protein N)
NRAM_I02A3 Neuraminidase (EC 3.2.1.18)
M1_I02A3 Matrix protein 1 (M1)
M2_I02A3 Matrix protein 2 (Proton channel protein M2)
NS1_I02A3 Non-structural protein 1 (NS1) (NS1A)
PB1F2_I02A3 Protein PB1-F2
RDRP_I02A3 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

8 entries

Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)

Select_allDeselect_all
NCAP_I03A0 Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I03A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
M1_I03A0 Matrix protein 1 (M1)
M2_I03A0 Matrix protein 2 (Proton channel protein M2)
NS1_I03A0 Non-structural protein 1 (NS1) (NS1A)
PB1F2_I03A0 Protein PB1-F2
PB2_I03A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I03A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

7 entries

Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)

Select_allDeselect_all
NEP_I01A2 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NCAP_I01A2 Nucleoprotein (Nucleocapsid protein) (Protein N)
M2_I01A2 Matrix protein 2 (Proton channel protein M2)
M1_I01A2 Matrix protein 1 (M1)
NS1_I01A2 Non-structural protein 1 (NS1) (NS1A)
PB1F2_I01A2 Protein PB1-F2
NRAM_I01A2 Neuraminidase (EC 3.2.1.18)

7 entries

Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)

Select_allDeselect_all
M2_I05A1 Matrix protein 2 (Proton channel protein M2)
M1_I05A1 Matrix protein 1 (M1)
PAX_I05A1 Protein PA-X
PA_I05A1 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
PB1F2_I05A1 Protein PB1-F2
PB2_I05A1 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I05A1 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

6 entries

Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)

Select_allDeselect_all
NCAP_I01A1 Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I01A1 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
M2_I01A1 Matrix protein 2 (Proton channel protein M2)
M1_I01A1 Matrix protein 1 (M1)
NS1_I01A1 Non-structural protein 1 (NS1) (NS1A)
PB1F2_I01A1 Protein PB1-F2

6 entries

Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)

Select_allDeselect_all
NEP_I02A1 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NCAP_I02A1 Nucleoprotein (Nucleocapsid protein) (Protein N)
PAX_I02A1 Protein PA-X
PB1F2_I02A1 Protein PB1-F2
NS1_I02A1 Non-structural protein 1 (NS1) (NS1A)
PA_I02A1 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

4 entries

Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)

Select_allDeselect_all
NCAP_I02A7 Nucleoprotein
PB1F2_I02A7 Protein PB1-F2
PB2_I02A7 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I02A7 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...