Polydnaviridae

VIRION

Enveloped, prolate ellipsoid form (ichnovirus) and cylindrical (bracovirus). Depending on the species, a virion contains one or several nucleocapsids.

GENOME

Segmented, circular supercoiled dsDNAs ranging from 2.0-31kb. Each virion contains multiple copies of the genome.

GENE EXPRESSION

REPLICATION

NUCLEAR

a) replicative: occurs in the calyx cells of the ovary.

  1. Excision and circularization of viral DNA in the ovary cells.
  2. Viral DNA synthesis.
  3. Appearance of viral envelopes and nucleocapsids in the nucleus.
  4. Mature virions are released into the lumen of the oviduct probably by lysis (brachovirus) or budding through the cell membrane (ichnovirus).

b) vegetative: occurs in all non-reproductive cells.

The viral genome is transmitted in proviral linear form integrated in the wasp’s chromosomes. The virus DNA is replicated, just like any other part of the wasp’s genome.

Host-virus interaction

Apoptosis modulation

PTP-H2 triggers mitochondrial membrane depolarization and caspase-dependent apoptosis suggesting that apoptosis is induced through a mitochondria-dependent death pathway.

NF-kappa-B modulation

Polydnavirus Ank proteins bind NF-kappa-B homodimers and inhibit processing of relish/NF-kappa-B p110 subunit .

Innate immune response inhibition

Microplitis demolitor cracovirus PTP-H2 and PTP-H3 are functional tyrosine phosphatases whose expression inhibit phagocytosis . Another protein, Glc1.8 is also involved in suppression of the insect cellular immune response .

Matching UniProtKB/Swiss-Prot entries

53 entries grouped by protein (browse by keywords)

All proteins are shown (view only 52 complete proteome entries)

1 entry

Probable protease inhibitor Egf0.4a

EG04A_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Probable protease inhibitor Egf0.4b

EG04B_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Protease inhibitor Egf1.0

EG10_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Protease inhibitor Egf1.5a

EG15A_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Protease inhibitor Egf1.5b

EG15B_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Mucin-like protein Glc1.8a

GL18A_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Mucin-like protein Glc1.8b (Glc1.8b)

GL18B_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein C1

IKBC1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein C2

IKBC2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein F1

IKBF1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein F2

IKBF2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein G1

IKBG1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein G2

IKBG2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein H1

IKBH1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein I1

IKBI1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein J1

IKBJ1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein N1

IKBN1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-kappa-B like protein N2

IKBN2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein N3

IKBN3_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Truncated tyrosine phosphatase D1 (PTP-D1)

PTPD1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Tyrosine phosphatase-like protein H1 (PTP-H1)

PTPH1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Tyrosine phosphatase H2 (PTP-H2) (EC 3.1.3.48)

PTPH2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Tyrosine phosphatase H3 (PTP-H3) (EC 3.1.3.48)

PTPH3_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Probable tyrosine phosphatase protein H4 (PTP-H4) (EC 3.1.3.48)

PTPH4_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Tyrosine phosphatase-like protein H5 (PTP-H5)

PTPH5_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Tyrosine phosphatase-like protein J1 (PTP-J1)

PTPJ1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Probable tyrosine phosphatase protein J2 (PTP-J2) (EC 3.1.3.48)

PTPJ2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Tyrosine phosphatase-like protein J3 (PTP-J3)

PTPJ3_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Probable tyrosine phosphatase protein J4 (PTP-J4) (EC 3.1.3.48)

PTPJ4_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Probable tyrosine phosphatase protein N1 (PTP-N1) (EC 3.1.3.48)

PTPN1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Tyrosine phosphatase-like protein N2 (PTP-N2)

PTPN2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Tyrosine phosphatase-like protein N3 (PTP-N3)

PTPN3_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Repeat element protein

REEP_CSIV
Campoletis sonorensis ichnovirus (CsIV)

1 entry

Uncharacterized protein A1

YA1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein A2

YA2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Putative BEN domain-containing protein B1

YB1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein C3

YC3_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein D2

YD2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein D3

YD3_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein E1

YE1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein E2

YE2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein F1

YF1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein G1

YG1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein G2

YG2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein I2

YI2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein K1

YK1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein L1

YL1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein M1

YM1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein M2

YM2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein M3

YM3_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein M4

YM4_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein M5

YM5_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Uncharacterized protein N1

YN1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain