Capripoxvirus

VIRION

Enveloped, brick-shaped , 300x270x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of about 154kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Sheeppox virus strain A genome at
Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Apoptosis modulation

Capripoxvirus SPI-2 inhibits the proteolytic activity of interleukin 1- converting enzyme (ICE) and ICE-like enzymes.

Matching UniProtKB/Swiss-Prot entries

14 entries grouped by protein (browse by keywords)

All proteins are shown (view only 3 complete proteome entries)

2 entries

Envelope protein A28 homolog (Protein HM3)

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A28_LSDVN
Lumpy skin disease virus (isolate Bovine/Kenya/Neethling 2490/1958) (LSDV) (Lumpy skin disease virus (isolate NI-2490)) reference strain

Envelope protein A28 homolog (Protein LSDV118)

A28_SHEVK
Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))

1 entry

Protein B14 homolog (Protein T3A)

B14_SHEVN
Sheeppox virus (strain InS-1) (SPPV) (Capripoxvirus (strain InS-1))

1 entry

Protein J1 homolog (Protein F7)

J1_SHEVK
Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))

1 entry

Thymidine kinase (EC 2.7.1.21)

KITH_SHEVK
Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))

1 entry

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)

LAP_LSDV
Lumpy skin disease virus (LSDV)

1 entry

Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)

PAP1_LSDVN
Lumpy skin disease virus (isolate Bovine/Kenya/Neethling 2490/1958) (LSDV) (Lumpy skin disease virus (isolate NI-2490)) reference strain

1 entry

Putative fusion protein (Protein HM2)

VFUS_SHEVK
Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))

2 entries

Probable host range protein 2

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VHR2_LSDVN
Lumpy skin disease virus (isolate Bovine/Kenya/Neethling 2490/1958) (LSDV) (Lumpy skin disease virus (isolate NI-2490))
VHR2_SHEVK
Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))

1 entry

G-protein coupled receptor homolog Q2/3L

VQ3L_SHEVK
Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))

1 entry

T3C protein

VT3C_SHEVK
Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))

2 entries

T4 protein

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VT4_SHEVK
Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))
VT4_SHEVN
Sheeppox virus (strain InS-1) (SPPV) (Capripoxvirus (strain InS-1))