Leporipoxvirus

VIRION

Enveloped, brick-shaped 300x250x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of 160kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Myxoma virus strain Lausanne genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Adaptive immune response inhibition

The poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules .

Apoptosis modulation

Myxoma virus M11L inhibits host apoptosis by preventing the conformational activation of host Bax at the mitochondria .

Cell-cycle modulation

The myxomavirus Ankyrin repeat domain-containing protein M-T5 is an adapter of SKP1-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins including CDKN1B. Disappearance of host CDKN1B correlates with cell cycle progression through the G0/G1 checkpoint .

Matching UniProtKB/Swiss-Prot entries

59 entries grouped by protein (browse by keywords)

All proteins are shown (view only 52 complete proteome entries)

2 entries

Transcript termination protein A18 (EC 3.6.4.-)

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A18_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
A18_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

3 entries

Envelope protein A28 homolog (MA28)

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A28_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain

Envelope protein A28 homolog (Protein M116)

A28_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

Envelope protein A28 homolog (Protein Gp116)

A28_MYXVU
Myxoma virus (strain Uriarra) (MYXV)

1 entry

Protein B14 homolog (Protein T3A)

B14_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

1 entry

mRNA-decapping protein D10 (EC 3.1.3.-)

D10_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

1 entry

Core protein D4

D2_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

1 entry

Core protein D3 homolog (27 kDa virion core protein)

D3_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

1 entry

mRNA-decapping protein D9 (EC 3.1.3.-)

D9_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

1 entry

Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)

DUSP_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain

2 entries

Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small subunit)

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ETF1_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
ETF1_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

2 entries

Early transcription factor 82 kDa subunit (ETF large subunit)

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ETF2_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
ETF2_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

2 entries

Growth factor (Secreted epidermal growth factor-like)

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GRFA_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
GRFA_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

3 entries

Thymidine kinase (EC 2.7.1.21)

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KITH_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
KITH_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain
KITH_MYXVU
Myxoma virus (strain Uriarra) (MYXV)

2 entries

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)

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LAP_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
LAP_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

2 entries

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) polymerase regulatory subunit) (Poly(A) polymerase small subunit) (PAP-S) (VP39)

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MCE_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
MCE_MYXVU
Myxoma virus (strain Uriarra) (MYXV)

1 entry

mRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) (VTF large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme large subunit)

MCEL_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

2 entries

Probable metalloendopeptidase G1-type (EC 3.4.24.-)

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MP44_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
MP44_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

1 entry

Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)

MT5_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain

2 entries

RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside triphosphate phosphohydrolase II) (NPH II)

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NPH2_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain

RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside triphosphate phosphohydrolase II) (NPH II) (RNA helicase m44R)

NPH2_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

2 entries

Nucleoside triphosphatase I (EC 3.6.1.15) (M86L protein) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH I)

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NTP1_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
NTP1_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH I)

2 entries

Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)

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PAP1_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
PAP1_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

2 entries

DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)

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RP07_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
RP07_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

2 entries

DNA-directed RNA polymerase 21 kDa subunit (EC 2.7.7.6)

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RP22_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
RP22_MYXVU
Myxoma virus (strain Uriarra) (MYXV)

1 entry

Serine proteinase inhibitor 1 (Serp-1) (Serpin-1)

SPI1_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain

2 entries

Serine proteinase inhibitor 2 (Serp-2) (Serpin-2)

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SPI2_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
SPI2_MYXVU
Myxoma virus (strain Uriarra) (MYXV)

1 entry

DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)

TOP1_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

1 entry

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)

UNG_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

3 entries

Probable host range protein 2-1

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VH21_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
VH21_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain
VH21_MYXVU
Myxoma virus (strain Uriarra) (MYXV)

2 entries

Probable host range protein 2-2

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VH22_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
VH22_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

2 entries

Probable host range protein 2-3

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VH23_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
VH23_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

2 entries

MF7 protein

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VMF7_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
VMF7_MYXVU
Myxoma virus (strain Uriarra) (MYXV)

1 entry

Kelch repeat protein M-T8

VMT8_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain

1 entry

Kelch repeat protein M-T9 (M9-R polypeptide)

VMT9_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain

1 entry

Protein T1

VT1_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

2 entries

Tumor necrosis factor soluble receptor (Protein T2)

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VT2_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
VT2_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

1 entry

T4 protein

VT4_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

1 entry

Ankyrin repeat protein T5

VT5_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain