Suipoxvirus

VIRION

Enveloped, brick-shaped about 300x250x200nm. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of 175kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Swinepox virus strain Nebraska 17077-99 genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Adaptive immune response inhibition

The poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules.

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by protein (browse by keywords)

All proteins are shown (view only 2 complete proteome entries)

1 entry

Scaffold protein D13 ortholog (62 kDa protein) (Rifampicin resistance protein)

D13_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

27 kDa core protein

D3_SWPV1
Swinepox virus (strain Swine/Nebraska/17077-99/1999) (SWPV) reference strain

1 entry

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

DUT_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

F9 protein homolog (Protein C19)

F9_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Protein K3 homolog

K3_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Thymidine kinase (EC 2.7.1.21)

KITH_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)

LAP_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

mRNA-capping enzyme small subunit (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.56) (mRNA cap methyltransferase)

MCES_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)

PAP1_SWPV1
Swinepox virus (strain Swine/Nebraska/17077-99/1999) (SWPV) reference strain

1 entry

Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

RIR2_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Probable serine proteinase inhibitor 1 (Serp-1) (Serpin-1)

SPI1_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Putative Ig-like domain-containing protein C1

VC01_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Uncharacterized protein C2

VC02_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

G-protein coupled receptor homolog C3

VC03_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Protein C4

VC04_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Uncharacterized protein C5

VC05_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Uncharacterized protein C6

VC06_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Uncharacterized protein C9

VC09_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Uncharacterized protein C10

VC10_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Uncharacterized protein C12

VC12_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Protein C13

VC13_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Uncharacterized protein C15

VC15_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Uncharacterized protein C16

VC16_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Uncharacterized protein C17

VC17_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Uncharacterized protein C18

VC18_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Probable host range protein 2

VHR2_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

G-protein coupled receptor homolog K2

VK02_SWPVK
Swinepox virus (strain Kasza) (SWPV)

1 entry

Serine/threonine-protein kinase 2 (EC 2.7.11.1)

VPK2_SWPVK
Swinepox virus (strain Kasza) (SWPV)