Yatapoxvirus

VIRION

Enveloped, brick-shaped about 300x250x200nm in size. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome about 145kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities. h4. GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Adaptive immune response inhibition

The poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules.

Matching UniProtKB/Swiss-Prot entries

19 entries grouped by protein (browse by keywords)

2 entries

Transcript termination protein A18 (EC 3.6.4.-)

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A18_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain
A18_YLDV
Yaba-like disease virus (YLDV)

2 entries

Envelope protein A28 homolog (Protein 118)

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A28_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain
A28_YLDV
Yaba-like disease virus (YLDV)

1 entry

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

DUT_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

1 entry

Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (VETF small subunit)

ETF1_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

1 entry

Early transcription factor 82 kDa subunit (ETF large subunit)

ETF2_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

1 entry

Thymidine kinase (EC 2.7.1.21)

KITH_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

2 entries

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)

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LAP_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase)

LAP_YLDV
Yaba-like disease virus (YLDV)

1 entry

mRNA-capping enzyme small subunit (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.56) (mRNA cap methyltransferase)

MCES_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

1 entry

Probable metalloendopeptidase G1-type (EC 3.4.24.-)

MP44_YLDV
Yaba-like disease virus (YLDV)

1 entry

Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH I)

NTP1_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

2 entries

Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)

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PAP1_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain
PAP1_YLDV
Yaba-like disease virus (YLDV)

1 entry

Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

RIR2_YLDV
Yaba-like disease virus (YLDV)

1 entry

DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)

RP07_YLDV
Yaba-like disease virus (YLDV)

2 entries

Probable host range protein 2

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VHR2_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain
VHR2_YLDV
Yaba-like disease virus (YLDV)