Deltavirus

Satellite virus: infection requires host cell to be co-infected with hepatitis B virus

Molecular biology

VIRION

Enveloped, spherical about 22 nm in diameter. Membrane proteins are originated from the HBV helper virus.

GENOME

Circular, ssRNA(-) genome of 1,68 kb. Most of the genome displays complementary strands. Replication occurs by rolling circle, single genome being cleaved/ligated by HDV ribozymes.

GENE EXPRESSION

A single ORF encodes for S-HDAg. Late in infection, genome editing by host ADAR1 extends the S-HDAg ORF by 19 amino acids, inducing production of L-HDAg. Edited genome seems to be unable to replicate.

REPLICATION

NUCLEAR

  1. Virus attaches to host receptors though Major surface antigen.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released in the cytoplasm and migrates to the nucleus.
  3. Transcription of S-HDAg, promoting viral transcription and replication
  4. Symmetrical rolling circle replication by host DNA-dependent RNA polymerase II
  5. later, genomic RNA is edited by host ADAR1, leading to L-HDAg expression which induce packaging of HDV genome at the RE.
  6. Budding by helper HBV proteins.

Host-virus interaction

Inhibition of host Interferon induction

HDV plays a role in inhibition of STAT1 antiviral signaling

Matching UniProtKB/Swiss-Prot entries

34 entries grouped by strain (browse by keywords)

2 entries

Hepatitis delta virus genotype I (isolate D380) (HDV) reference strain

Select_allDeselect_all
SHDAG_HDVD3 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVD3 Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype I (isolate American) (HDV)

Select_allDeselect_all
SHDAG_HDVAM Small delta antigen (S-HDAg) (p24)
LHDAG_HDVAM Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype I (isolate Italian) (HDV)

Select_allDeselect_all
LHDAG_HDVIT Large delta antigen (L-HDAg) (p27)
SHDAG_HDVIT Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype I (isolate Japanese M-1) (HDV)

Select_allDeselect_all
LHDAG_HDVM1 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVM1 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype I (isolate Japanese M-2) (HDV)

Select_allDeselect_all
SHDAG_HDVM2 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVM2 Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype I (isolate Japanese S-2) (HDV)

Select_allDeselect_all
SHDAG_HDVS2 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVS2 Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype I (isolate Lebanon-1) (HDV)

Select_allDeselect_all
SHDAG_HDVL1 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVL1 Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype I (isolate Nauru) (HDV)

Select_allDeselect_all
SHDAG_HDVNA Small delta antigen (S-HDAg) (p24)
LHDAG_HDVNA Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype I (isolate US-2) (HDV)

Select_allDeselect_all
SHDAG_HDVU2 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVU2 Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype I (isolate Woodchuck) (HDV)

Select_allDeselect_all
SHDAG_HDVWO Small delta antigen (S-HDAg) (p24)
LHDAG_HDVWO Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype II (isolate 7/18/83) (HDV)

Select_allDeselect_all
LHDAG_HDV83 Large delta antigen (L-HDAg) (p27)
SHDAG_HDV83 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype II (isolate Japanese S-1) (HDV)

Select_allDeselect_all
LHDAG_HDVS1 Large delta antigen (L-HDAg) (p27)
SHDAG_HDVS1 Small delta antigen (S-HDAg) (p24)

2 entries

Hepatitis delta virus genotype II (isolate TW2476) (HDV)

Select_allDeselect_all
SHDAG_HDVTW Small delta antigen (S-HDAg) (p24)
LHDAG_HDVTW Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype III (isolate Peru-1) (HDV)

Select_allDeselect_all
SHDAG_HDVP1 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVP1 Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype III (isolate VnzD8349) (HDV)

Select_allDeselect_all
SHDAG_HDVV2 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVV2 Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype III (isolate VnzD8375) (HDV)

Select_allDeselect_all
SHDAG_HDVV3 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVV3 Large delta antigen (L-HDAg) (p27)

2 entries

Hepatitis delta virus genotype III (isolate VnzD8624) (HDV)

Select_allDeselect_all
SHDAG_HDVV1 Small delta antigen (S-HDAg) (p24)
LHDAG_HDVV1 Large delta antigen (L-HDAg) (p27)