Alphapapillomavirus

VIRION

Non-enveloped. Small, icosahedral, about 60 nm in size. A single molecule of circular dsDNA is contained within the T=7 icosahedral capsid, which is composed of 72 pentamers.

GENOME

Circular dsDNA, about 8 kb in size, associated with cellular histones.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.

GENE EXPRESSION

Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing :
a) Early Proteins: non-structural regulatory proteins (E1-E7).
b) Late Proteins: the structural proteins L1 and L2. E7 can be expressed by leaky scanning from the E6 mRNA.

REPLICATION

NUCLEAR

Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.

b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.

  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.

Host-virus interaction

Adaptive immune response inhibition

The E5 protein in papillomaviruses plays a role in the inhibition of host adaptive response by down-regulating the cell surface expression of MHC class I .

Apoptosis modulation

The HPV16-E6 protein has the ability to prevent apoptosis of infected cells through its binding to FADD and caspase 8 .

Cell-cycle modulation

The E7 protein from the high-risk HPV type 18 forms a complex with cyclin E and regulates transit from G1 to S. E7 binds also cyclin A, which regulates transit through the S and G2/M phases of the cell cycle .

Innate immune response inhibition

Papillomaviruses inhibits the cascade leading to production of interferon-beta by targeting the IRF3 cellular protein. Indeed, The viral E6 protein is able to interact with host IRF3 and inhibits its transcriptional activity .

Matching UniProtKB/Swiss-Prot entries

303 entries grouped by protein (browse by keywords)

All proteins are shown (view only 293 complete proteome entries)

40 entries

Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)

Select_allDeselect_all
VE1_HPV07
Human papillomavirus type 7 reference strain
VE1_HPV10
Human papillomavirus type 10 reference strain
VE1_HPV11
Human papillomavirus type 11 reference strain
VE1_HPV16
Human papillomavirus type 16 reference strain
VE1_HPV18
Human papillomavirus type 18 reference strain
VE1_HPV27
Human papillomavirus type 27 reference strain
VE1_HPV29
Human papillomavirus type 29 reference strain
VE1_HPV2A
Human papillomavirus type 2a reference strain
VE1_HPV30
Human papillomavirus type 30 reference strain
VE1_HPV31
Human papillomavirus type 31 reference strain
VE1_HPV33
Human papillomavirus type 33 reference strain
VE1_HPV34
Human papillomavirus type 34 reference strain
VE1_HPV35
Human papillomavirus type 35 reference strain
VE1_HPV42
Human papillomavirus type 42 reference strain
VE1_HPV45
Human papillomavirus type 45 reference strain
VE1_HPV51
Human papillomavirus type 51 reference strain
VE1_HPV52
Human papillomavirus type 52 reference strain
VE1_HPV54
Human papillomavirus type 54 reference strain
VE1_HPV58
Human papillomavirus type 58 reference strain
VE1_HPV61
Human papillomavirus type 61 reference strain
VE1_HPV69
Human papillomavirus type 69 reference strain
VE1_PCPV1
Pygmy chimpanzee papillomavirus type 1 (PCPV-1) reference strain
VE1_HPV03
Human papillomavirus type 3
VE1_HPV13
Human papillomavirus type 13
VE1_HPV26
Human papillomavirus type 26
VE1_HPV28
Human papillomavirus type 28
VE1_HPV32
Human papillomavirus type 32
VE1_HPV39
Human papillomavirus type 39
VE1_HPV40
Human papillomavirus type 40
VE1_HPV44
Human papillomavirus type 44
VE1_HPV57
Human papillomavirus type 57
VE1_HPV59
Human papillomavirus type 59
VE1_HPV66
Human papillomavirus type 66
VE1_HPV6A
Human papillomavirus type 6a
VE1_HPV6B
Human papillomavirus type 6b
VE1_HPV70
Human papillomavirus type 70
VE1_HPV72
Human papillomavirus type 72
VE1_HPV73
Human papillomavirus type 73
VE1_PCPVC
Pygmy chimpanzee papillomavirus type 1C (PCPV-1C)
VE1_RHPV1
Rhesus papillomavirus type 1 (Rhpv 1)

39 entries

Regulatory protein E2

Select_allDeselect_all
VE2_HPV07
Human papillomavirus type 7 reference strain
VE2_HPV10
Human papillomavirus type 10 reference strain
VE2_HPV11
Human papillomavirus type 11 reference strain
VE2_HPV16
Human papillomavirus type 16 reference strain
VE2_HPV18
Human papillomavirus type 18 reference strain
VE2_HPV27
Human papillomavirus type 27 reference strain
VE2_HPV29
Human papillomavirus type 29 reference strain
VE2_HPV2A
Human papillomavirus type 2a reference strain
VE2_HPV30
Human papillomavirus type 30 reference strain
VE2_HPV31
Human papillomavirus type 31 reference strain
VE2_HPV33
Human papillomavirus type 33 reference strain
VE2_HPV34
Human papillomavirus type 34 reference strain
VE2_HPV35
Human papillomavirus type 35 reference strain
VE2_HPV42
Human papillomavirus type 42 reference strain
VE2_HPV45
Human papillomavirus type 45 reference strain
VE2_HPV51
Human papillomavirus type 51 reference strain
VE2_HPV52
Human papillomavirus type 52 reference strain
VE2_HPV54
Human papillomavirus type 54 reference strain
VE2_HPV56
Human papillomavirus type 56 reference strain
VE2_HPV58
Human papillomavirus type 58 reference strain
VE2_HPV61
Human papillomavirus type 61 reference strain
VE2_HPV69
Human papillomavirus type 69 reference strain
VE2_PCPV1
Pygmy chimpanzee papillomavirus type 1 (PCPV-1) reference strain
VE2_HPV03
Human papillomavirus type 3
VE2_HPV13
Human papillomavirus type 13
VE2_HPV26
Human papillomavirus type 26
VE2_HPV28
Human papillomavirus type 28
VE2_HPV32
Human papillomavirus type 32
VE2_HPV39
Human papillomavirus type 39
VE2_HPV40
Human papillomavirus type 40
VE2_HPV44
Human papillomavirus type 44
VE2_HPV53
Human papillomavirus type 53
VE2_HPV55
Human papillomavirus type 55
VE2_HPV57
Human papillomavirus type 57
VE2_HPV66
Human papillomavirus type 66
VE2_HPV6A
Human papillomavirus type 6a
VE2_HPV6B
Human papillomavirus type 6b
VE2_HPV70
Human papillomavirus type 70
VE2_RHPV1
Rhesus papillomavirus type 1 (Rhpv 1)

21 entries

Protein E4

Select_allDeselect_all
VE4_HPV11
Human papillomavirus type 11 reference strain
VE4_HPV16
Human papillomavirus type 16 reference strain

Protein E4 (E1^E4)

VE4_HPV18
Human papillomavirus type 18 reference strain
VE4_HPV29
Human papillomavirus type 29 reference strain
VE4_HPV2A
Human papillomavirus type 2a reference strain
VE4_HPV31
Human papillomavirus type 31 reference strain
VE4_HPV33
Human papillomavirus type 33 reference strain

Protein E4 (E1^E4)

VE4_HPV42
Human papillomavirus type 42 reference strain
VE4_HPV51
Human papillomavirus type 51 reference strain
VE4_HPV54
Human papillomavirus type 54 reference strain
VE4_HPV58
Human papillomavirus type 58 reference strain
VE4_PCPV1
Pygmy chimpanzee papillomavirus type 1 (PCPV-1) reference strain

Probable protein E4

VE4_HPV13
Human papillomavirus type 13
VE4_HPV28
Human papillomavirus type 28
VE4_HPV35
Human papillomavirus type 35
VE4_HPV39
Human papillomavirus type 39
VE4_HPV57
Human papillomavirus type 57
VE4_HPV6A
Human papillomavirus type 6a
VE4_HPV6B
Human papillomavirus type 6b

Protein E4 (E1^E4)

VE4_HPV6C
Human papillomavirus type 6c

Probable protein E4

VE4_RHPV1
Rhesus papillomavirus type 1 (Rhpv 1)

Probable protein E4

13 entries

Probable protein E5

Select_allDeselect_all
VE5_HPV16
Human papillomavirus type 16 reference strain
VE5_HPV18
Human papillomavirus type 18 reference strain
VE5_HPV31
Human papillomavirus type 31 reference strain
VE5_HPV33
Human papillomavirus type 33 reference strain
VE5_HPV42
Human papillomavirus type 42 reference strain
VE5_HPV51
Human papillomavirus type 51 reference strain
VE5_HPV58
Human papillomavirus type 58 reference strain
VE5_PCPV1
Pygmy chimpanzee papillomavirus type 1 (PCPV-1) reference strain
VE5_HPV13
Human papillomavirus type 13
VE5_HPV35
Human papillomavirus type 35
VE5_HPV39
Human papillomavirus type 39
VE5_HPV70
Human papillomavirus type 70
VE5_RHPV1
Rhesus papillomavirus type 1 (Rhpv 1)

4 entries

Probable protein E5A

Select_allDeselect_all
VE5A_HPV11
Human papillomavirus type 11 reference strain
VE5A_HPV6A
Human papillomavirus type 6a
VE5A_HPV6B
Human papillomavirus type 6b
VE5A_HPV6C
Human papillomavirus type 6c

3 entries

Probable protein E5B

Select_allDeselect_all
VE5B_HPV11
Human papillomavirus type 11 reference strain
VE5B_HPV6B
Human papillomavirus type 6b
VE5B_HPV6C
Human papillomavirus type 6c

41 entries

Protein E6

Select_allDeselect_all
VE6_HPV07
Human papillomavirus type 7 reference strain
VE6_HPV10
Human papillomavirus type 10 reference strain
VE6_HPV11
Human papillomavirus type 11 reference strain
VE6_HPV16
Human papillomavirus type 16 reference strain
VE6_HPV18
Human papillomavirus type 18 reference strain
VE6_HPV27
Human papillomavirus type 27 reference strain
VE6_HPV29
Human papillomavirus type 29 reference strain
VE6_HPV2A
Human papillomavirus type 2a reference strain
VE6_HPV30
Human papillomavirus type 30 reference strain
VE6_HPV31
Human papillomavirus type 31 reference strain
VE6_HPV33
Human papillomavirus type 33 reference strain
VE6_HPV34
Human papillomavirus type 34 reference strain
VE6_HPV35
Human papillomavirus type 35 reference strain
VE6_HPV42
Human papillomavirus type 42 reference strain
VE6_HPV45
Human papillomavirus type 45 reference strain
VE6_HPV51
Human papillomavirus type 51 reference strain
VE6_HPV52
Human papillomavirus type 52 reference strain
VE6_HPV54
Human papillomavirus type 54 reference strain
VE6_HPV56
Human papillomavirus type 56 reference strain
VE6_HPV58
Human papillomavirus type 58 reference strain
VE6_HPV61
Human papillomavirus type 61 reference strain
VE6_HPV69
Human papillomavirus type 69 reference strain
VE6_PCPV1
Pygmy chimpanzee papillomavirus type 1 (PCPV-1) reference strain
VE6_HPV03
Human papillomavirus type 3
VE6_HPV13
Human papillomavirus type 13
VE6_HPV26
Human papillomavirus type 26
VE6_HPV28
Human papillomavirus type 28
VE6_HPV32
Human papillomavirus type 32
VE6_HPV39
Human papillomavirus type 39
VE6_HPV40
Human papillomavirus type 40
VE6_HPV43
Human papillomavirus type 43
VE6_HPV44
Human papillomavirus type 44
VE6_HPV53
Human papillomavirus type 53
VE6_HPV57
Human papillomavirus type 57
VE6_HPV66
Human papillomavirus type 66
VE6_HPV68
Human papillomavirus type 68
VE6_HPV6A
Human papillomavirus type 6a
VE6_HPV6B
Human papillomavirus type 6b
VE6_HPV70
Human papillomavirus type 70
VE6_HPV94
Human papillomavirus type 94
VE6_RHPV1
Rhesus papillomavirus type 1 (Rhpv 1)

40 entries

Protein E7

Select_allDeselect_all
VE7_HPV07
Human papillomavirus type 7 reference strain
VE7_HPV10
Human papillomavirus type 10 reference strain
VE7_HPV11
Human papillomavirus type 11 reference strain
VE7_HPV16
Human papillomavirus type 16 reference strain
VE7_HPV18
Human papillomavirus type 18 reference strain
VE7_HPV27
Human papillomavirus type 27 reference strain
VE7_HPV29
Human papillomavirus type 29 reference strain
VE7_HPV2A
Human papillomavirus type 2a reference strain
VE7_HPV30
Human papillomavirus type 30 reference strain
VE7_HPV31
Human papillomavirus type 31 reference strain
VE7_HPV33
Human papillomavirus type 33 reference strain
VE7_HPV34
Human papillomavirus type 34 reference strain
VE7_HPV35
Human papillomavirus type 35 reference strain
VE7_HPV42
Human papillomavirus type 42 reference strain
VE7_HPV45
Human papillomavirus type 45 reference strain
VE7_HPV51
Human papillomavirus type 51 reference strain
VE7_HPV52
Human papillomavirus type 52 reference strain
VE7_HPV54
Human papillomavirus type 54 reference strain
VE7_HPV56
Human papillomavirus type 56 reference strain
VE7_HPV58
Human papillomavirus type 58 reference strain
VE7_HPV61
Human papillomavirus type 61 reference strain
VE7_HPV69
Human papillomavirus type 69 reference strain
VE7_PCPV1
Pygmy chimpanzee papillomavirus type 1 (PCPV-1) reference strain
VE7_HPV13
Human papillomavirus type 13
VE7_HPV26
Human papillomavirus type 26
VE7_HPV28
Human papillomavirus type 28
VE7_HPV32
Human papillomavirus type 32
VE7_HPV39
Human papillomavirus type 39
VE7_HPV40
Human papillomavirus type 40
VE7_HPV44
Human papillomavirus type 44
VE7_HPV53
Human papillomavirus type 53
VE7_HPV55
Human papillomavirus type 55
VE7_HPV57
Human papillomavirus type 57
VE7_HPV66
Human papillomavirus type 66
VE7_HPV68
Human papillomavirus type 68
VE7_HPV6A
Human papillomavirus type 6a
VE7_HPV6B
Human papillomavirus type 6b
VE7_HPV70
Human papillomavirus type 70
VE7_HPV94
Human papillomavirus type 94
VE7_RHPV1
Rhesus papillomavirus type 1 (Rhpv 1)

15 entries

Protein E8^E2C

Select_allDeselect_all
VE8E2_HPV11
Human papillomavirus type 11 reference strain
VE8E2_HPV16
Human papillomavirus type 16 reference strain
VE8E2_HPV18
Human papillomavirus type 18 reference strain
VE8E2_HPV29
Human papillomavirus type 29 reference strain
VE8E2_HPV31
Human papillomavirus type 31 reference strain
VE8E2_HPV33
Human papillomavirus type 33 reference strain
VE8E2_HPV42
Human papillomavirus type 42 reference strain
VE8E2_HPV51
Human papillomavirus type 51 reference strain
VE8E2_HPV54
Human papillomavirus type 54 reference strain
VE8E2_HPV58
Human papillomavirus type 58 reference strain
VE8E2_HPV13
Human papillomavirus type 13
VE8E2_HPV28
Human papillomavirus type 28
VE8E2_HPV35
Human papillomavirus type 35
VE8E2_HPV39
Human papillomavirus type 39
VE8E2_HPV57
Human papillomavirus type 57

44 entries

Major capsid protein L1

Select_allDeselect_all
VL1_HPV07
Human papillomavirus type 7 reference strain
VL1_HPV10
Human papillomavirus type 10 reference strain
VL1_HPV11
Human papillomavirus type 11 reference strain
VL1_HPV16
Human papillomavirus type 16 reference strain
VL1_HPV18
Human papillomavirus type 18 reference strain
VL1_HPV27
Human papillomavirus type 27 reference strain
VL1_HPV29
Human papillomavirus type 29 reference strain
VL1_HPV2A
Human papillomavirus type 2a reference strain
VL1_HPV30
Human papillomavirus type 30 reference strain
VL1_HPV31
Human papillomavirus type 31 reference strain
VL1_HPV33
Human papillomavirus type 33 reference strain
VL1_HPV34
Human papillomavirus type 34 reference strain
VL1_HPV35
Human papillomavirus type 35 reference strain
VL1_HPV42
Human papillomavirus type 42 reference strain
VL1_HPV43
Human papillomavirus type 43 reference strain
VL1_HPV45
Human papillomavirus type 45 reference strain
VL1_HPV51
Human papillomavirus type 51 reference strain
VL1_HPV52
Human papillomavirus type 52 reference strain
VL1_HPV54
Human papillomavirus type 54 reference strain
VL1_HPV56
Human papillomavirus type 56 reference strain
VL1_HPV58
Human papillomavirus type 58 reference strain
VL1_HPV61
Human papillomavirus type 61 reference strain
VL1_HPV62
Human papillomavirus type 62 reference strain
VL1_HPV69
Human papillomavirus type 69 reference strain
VL1_PCPV1
Pygmy chimpanzee papillomavirus type 1 (PCPV-1) reference strain
VL1_HPV03
Human papillomavirus type 3
VL1_HPV13
Human papillomavirus type 13
VL1_HPV26
Human papillomavirus type 26
VL1_HPV28
Human papillomavirus type 28
VL1_HPV32
Human papillomavirus type 32
VL1_HPV39
Human papillomavirus type 39
VL1_HPV40
Human papillomavirus type 40
VL1_HPV44
Human papillomavirus type 44
VL1_HPV53
Human papillomavirus type 53
VL1_HPV55
Human papillomavirus type 55
VL1_HPV57
Human papillomavirus type 57
VL1_HPV66
Human papillomavirus type 66
VL1_HPV67
Human papillomavirus type 67
VL1_HPV68
Human papillomavirus type 68
VL1_HPV6A
Human papillomavirus type 6a
VL1_HPV6B
Human papillomavirus type 6b
VL1_HPV70
Human papillomavirus type 70
VL1_HPV82
Human papillomavirus type 82
VL1_RHPV1
Rhesus papillomavirus type 1 (Rhpv 1)

43 entries

Minor capsid protein L2

Select_allDeselect_all
VL2_HPV07
Human papillomavirus type 7 reference strain
VL2_HPV10
Human papillomavirus type 10 reference strain
VL2_HPV11
Human papillomavirus type 11 reference strain
VL2_HPV16
Human papillomavirus type 16 reference strain
VL2_HPV18
Human papillomavirus type 18 reference strain
VL2_HPV27
Human papillomavirus type 27 reference strain
VL2_HPV29
Human papillomavirus type 29 reference strain
VL2_HPV2A
Human papillomavirus type 2a reference strain
VL2_HPV30
Human papillomavirus type 30 reference strain
VL2_HPV31
Human papillomavirus type 31 reference strain
VL2_HPV33
Human papillomavirus type 33 reference strain
VL2_HPV34
Human papillomavirus type 34 reference strain
VL2_HPV35
Human papillomavirus type 35 reference strain
VL2_HPV42
Human papillomavirus type 42 reference strain
VL2_HPV43
Human papillomavirus type 43 reference strain
VL2_HPV45
Human papillomavirus type 45 reference strain
VL2_HPV51
Human papillomavirus type 51 reference strain
VL2_HPV52
Human papillomavirus type 52 reference strain
VL2_HPV54
Human papillomavirus type 54 reference strain
VL2_HPV56
Human papillomavirus type 56 reference strain
VL2_HPV58
Human papillomavirus type 58 reference strain
VL2_HPV61
Human papillomavirus type 61 reference strain
VL2_HPV62
Human papillomavirus type 62 reference strain
VL2_HPV69
Human papillomavirus type 69 reference strain
VL2_PCPV1
Pygmy chimpanzee papillomavirus type 1 (PCPV-1) reference strain
VL2_HPV03
Human papillomavirus type 3
VL2_HPV13
Human papillomavirus type 13
VL2_HPV26
Human papillomavirus type 26
VL2_HPV28
Human papillomavirus type 28
VL2_HPV32
Human papillomavirus type 32
VL2_HPV39
Human papillomavirus type 39
VL2_HPV40
Human papillomavirus type 40
VL2_HPV44
Human papillomavirus type 44
VL2_HPV53
Human papillomavirus type 53
VL2_HPV55
Human papillomavirus type 55
VL2_HPV57
Human papillomavirus type 57
VL2_HPV66
Human papillomavirus type 66
VL2_HPV67
Human papillomavirus type 67
VL2_HPV6A
Human papillomavirus type 6a
VL2_HPV6B
Human papillomavirus type 6b
VL2_HPV70
Human papillomavirus type 70
VL2_HPV82
Human papillomavirus type 82
VL2_RHPV1
Rhesus papillomavirus type 1 (Rhpv 1)