Betapapillomavirus

VIRION

Non-enveloped. Small, icosahedral, about 60 nm in size. A single molecule of circular dsDNA is contained within the T=7 icosahedral capsid, which is composed of 72 pentamers.

GENOME

Circular dsDNA, about 8 kb in size, associated with cellular histones.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.

GENE EXPRESSION

Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing:
a) Early Proteins: non-structural regulatory proteins (E1-E7).
b) Late Proteins: the structural proteins L1 and L2.

REPLICATION

NUCLEAR

Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.

b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.

  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.

Matching UniProtKB/Swiss-Prot entries

128 entries grouped by protein (browse by keywords)

All proteins are shown (view only 127 complete proteome entries)

21 entries

Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)

Select_allDeselect_all
VE1_HPV05
Human papillomavirus type 5 reference strain
VE1_HPV22
Human papillomavirus type 22 reference strain
VE1_HPV25
Human papillomavirus type 25 reference strain
VE1_HPV38
Human papillomavirus type 38 reference strain
VE1_HPV08
Human papillomavirus type 8
VE1_HPV09
Human papillomavirus type 9
VE1_HPV12
Human papillomavirus type 12
VE1_HPV14
Human papillomavirus type 14
VE1_HPV15
Human papillomavirus type 15
VE1_HPV17
Human papillomavirus type 17
VE1_HPV19
Human papillomavirus type 19
VE1_HPV20
Human papillomavirus type 20
VE1_HPV21
Human papillomavirus type 21
VE1_HPV23
Human papillomavirus type 23
VE1_HPV24
Human papillomavirus type 24
VE1_HPV36
Human papillomavirus type 36
VE1_HPV37
Human papillomavirus type 37
VE1_HPV47
Human papillomavirus type 47
VE1_HPV49
Human papillomavirus type 49
VE1_HPV5B
Human papillomavirus type 5b
VE1_HPVR7
Human papillomavirus type RTRX7

20 entries

Regulatory protein E2

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VE2_HPV05
Human papillomavirus type 5 reference strain
VE2_HPV22
Human papillomavirus type 22 reference strain
VE2_HPV25
Human papillomavirus type 25 reference strain
VE2_HPV38
Human papillomavirus type 38 reference strain
VE2_HPV08
Human papillomavirus type 8
VE2_HPV09
Human papillomavirus type 9
VE2_HPV12
Human papillomavirus type 12
VE2_HPV14
Human papillomavirus type 14
VE2_HPV15
Human papillomavirus type 15
VE2_HPV17
Human papillomavirus type 17
VE2_HPV19
Human papillomavirus type 19
VE2_HPV20
Human papillomavirus type 20
VE2_HPV21
Human papillomavirus type 21
VE2_HPV23
Human papillomavirus type 23
VE2_HPV24
Human papillomavirus type 24
VE2_HPV36
Human papillomavirus type 36
VE2_HPV37
Human papillomavirus type 37
VE2_HPV47
Human papillomavirus type 47
VE2_HPV49
Human papillomavirus type 49
VE2_HPV5B
Human papillomavirus type 5b

4 entries

Protein E4

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VE4_HPV05
Human papillomavirus type 5 reference strain
VE4_HPV08
Human papillomavirus type 8
VE4_HPV47
Human papillomavirus type 47
VE4_HPV5B
Human papillomavirus type 5b

1 entry

Probable protein E5

VE5_HPV5B
Human papillomavirus type 5b

19 entries

Protein E6

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VE6_HPV05
Human papillomavirus type 5 reference strain
VE6_HPV22
Human papillomavirus type 22 reference strain
VE6_HPV25
Human papillomavirus type 25 reference strain
VE6_HPV38
Human papillomavirus type 38 reference strain
VE6_HPV08
Human papillomavirus type 8
VE6_HPV09
Human papillomavirus type 9
VE6_HPV12
Human papillomavirus type 12
VE6_HPV14
Human papillomavirus type 14
VE6_HPV15
Human papillomavirus type 15
VE6_HPV17
Human papillomavirus type 17
VE6_HPV19
Human papillomavirus type 19
VE6_HPV20
Human papillomavirus type 20
VE6_HPV21
Human papillomavirus type 21
VE6_HPV23
Human papillomavirus type 23
VE6_HPV24
Human papillomavirus type 24
VE6_HPV36
Human papillomavirus type 36
VE6_HPV47
Human papillomavirus type 47
VE6_HPV49
Human papillomavirus type 49
VE6_HPV5B
Human papillomavirus type 5b

19 entries

Protein E7

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VE7_HPV05
Human papillomavirus type 5 reference strain
VE7_HPV22
Human papillomavirus type 22 reference strain
VE7_HPV25
Human papillomavirus type 25 reference strain
VE7_HPV38
Human papillomavirus type 38 reference strain
VE7_HPV08
Human papillomavirus type 8
VE7_HPV09
Human papillomavirus type 9
VE7_HPV12
Human papillomavirus type 12
VE7_HPV15
Human papillomavirus type 15
VE7_HPV17
Human papillomavirus type 17
VE7_HPV19
Human papillomavirus type 19
VE7_HPV20
Human papillomavirus type 20
VE7_HPV21
Human papillomavirus type 21
VE7_HPV23
Human papillomavirus type 23
VE7_HPV24
Human papillomavirus type 24
VE7_HPV36
Human papillomavirus type 36
VE7_HPV37
Human papillomavirus type 37
VE7_HPV47
Human papillomavirus type 47
VE7_HPV49
Human papillomavirus type 49
VE7_HPV5B
Human papillomavirus type 5b

3 entries

Protein E8^E2C

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VE8E2_HPV05
Human papillomavirus type 5 reference strain
VE8E2_HPV08
Human papillomavirus type 8
VE8E2_HPV47
Human papillomavirus type 47

20 entries

Major capsid protein L1

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VL1_HPV05
Human papillomavirus type 5 reference strain
VL1_HPV22
Human papillomavirus type 22 reference strain
VL1_HPV25
Human papillomavirus type 25 reference strain
VL1_HPV38
Human papillomavirus type 38 reference strain
VL1_HPV08
Human papillomavirus type 8
VL1_HPV09
Human papillomavirus type 9
VL1_HPV12
Human papillomavirus type 12
VL1_HPV14
Human papillomavirus type 14
VL1_HPV15
Human papillomavirus type 15
VL1_HPV17
Human papillomavirus type 17
VL1_HPV19
Human papillomavirus type 19
VL1_HPV20
Human papillomavirus type 20
VL1_HPV21
Human papillomavirus type 21
VL1_HPV23
Human papillomavirus type 23
VL1_HPV24
Human papillomavirus type 24
VL1_HPV36
Human papillomavirus type 36
VL1_HPV37
Human papillomavirus type 37
VL1_HPV47
Human papillomavirus type 47
VL1_HPV49
Human papillomavirus type 49
VL1_HPV5B
Human papillomavirus type 5b

20 entries

Minor capsid protein L2

Select_allDeselect_all
VL2_HPV05
Human papillomavirus type 5 reference strain
VL2_HPV22
Human papillomavirus type 22 reference strain
VL2_HPV25
Human papillomavirus type 25 reference strain
VL2_HPV38
Human papillomavirus type 38 reference strain
VL2_HPV08
Human papillomavirus type 8
VL2_HPV09
Human papillomavirus type 9
VL2_HPV12
Human papillomavirus type 12
VL2_HPV14
Human papillomavirus type 14
VL2_HPV15
Human papillomavirus type 15
VL2_HPV17
Human papillomavirus type 17
VL2_HPV19
Human papillomavirus type 19
VL2_HPV20
Human papillomavirus type 20
VL2_HPV21
Human papillomavirus type 21
VL2_HPV23
Human papillomavirus type 23
VL2_HPV24
Human papillomavirus type 24
VL2_HPV36
Human papillomavirus type 36
VL2_HPV37
Human papillomavirus type 37
VL2_HPV47
Human papillomavirus type 47
VL2_HPV49
Human papillomavirus type 49
VL2_HPV5B
Human papillomavirus type 5b

1 entry

Probable protein L3

VL3_HPV5B
Human papillomavirus type 5b