Gammapapillomavirus

VIRION

Non-enveloped. Small, icosahedral, about 60 nm in size. A single molecule of circular dsDNA is contained within the T=7 icosahedral capsid, which is composed of 72 pentamers.

GENOME

Circular dsDNA, about 8 kb in size, associated with cellular histones.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.

GENE EXPRESSION

Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing :
a) Early Proteins: non-structural regulatory proteins (E1-E7).
b) Late Proteins: the structural proteins L1 and L2.

REPLICATION

NUCLEAR

Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.

b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.

  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.

Matching UniProtKB/Swiss-Prot entries

32 entries grouped by protein (browse by keywords)

4 entries

Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)

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VE1_HPV04
Human papillomavirus type 4 reference strain
VE1_HPV48
Human papillomavirus type 48 reference strain
VE1_HPV60
Human papillomavirus type 60
VE1_HPV65
Human papillomavirus type 65

5 entries

Regulatory protein E2

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VE2_HPV04
Human papillomavirus type 4 reference strain
VE2_HPV48
Human papillomavirus type 48 reference strain
VE2_HPV50
Human papillomavirus type 50 reference strain
VE2_HPV60
Human papillomavirus type 60
VE2_HPV65
Human papillomavirus type 65

2 entries

Protein E4

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VE4_HPV04
Human papillomavirus type 4 reference strain
VE4_HPV65
Human papillomavirus type 65

4 entries

Protein E6

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VE6_HPV04
Human papillomavirus type 4 reference strain
VE6_HPV48
Human papillomavirus type 48 reference strain
VE6_HPV60
Human papillomavirus type 60
VE6_HPV65
Human papillomavirus type 65

5 entries

Protein E7

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VE7_HPV04
Human papillomavirus type 4 reference strain
VE7_HPV48
Human papillomavirus type 48 reference strain
VE7_HPV50
Human papillomavirus type 50 reference strain
VE7_HPV60
Human papillomavirus type 60
VE7_HPV65
Human papillomavirus type 65

2 entries

Protein E8^E2C

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VE8E2_HPV04
Human papillomavirus type 4 reference strain
VE8E2_HPV65
Human papillomavirus type 65

5 entries

Major capsid protein L1

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VL1_HPV04
Human papillomavirus type 4 reference strain
VL1_HPV48
Human papillomavirus type 48 reference strain
VL1_HPV50
Human papillomavirus type 50 reference strain
VL1_HPV60
Human papillomavirus type 60
VL1_HPV65
Human papillomavirus type 65

5 entries

Minor capsid protein L2

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VL2_HPV04
Human papillomavirus type 4 reference strain
VL2_HPV48
Human papillomavirus type 48 reference strain
VL2_HPV50
Human papillomavirus type 50 reference strain
VL2_HPV60
Human papillomavirus type 60
VL2_HPV65
Human papillomavirus type 65