Gammaherpesvirinae

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter,T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Gamma-herpesviruses have evolved different strategies to inhibit the host adaptive immune response. For example, the EHV-2 viral interleukin-10 homolog down-regulates the expression of the TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Apoptosis modulation

Apoptosis is very often modulated (and usually inhibited) by gamma-herpesviruses. For example, Epstein-Barr, HHV-8 or AlHV-1 all possess a viral homologue of the Bcl-2 oncogene that is able to protect cells from induced apoptosis.

Autophagy modulation

Several gamma-herpesviruses are able to inhibit host autophagy process, via interaction of vBcl-2 and vFLIP with host Beclin 1 and Atg3 respectively, that impact two stages of autophagy.

Cell-cycle modulation

The UL24 protein that is present in all herpesvirus subfamilies (alpha, beta and gamma-herpesviruses) induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

Herpes viruses inhibit the cascade leading to production of interferon-beta by mainly targeting the host IRF3 protein. EBV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the BGLF4 protein kinase that directly interacts with and inhibits host IRF3. BRLF1 expression also decreases induction of IFN-beta, and reduces expression of IRF3 and IRF7.

Host splicing inhibition

Modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

520 entries grouped by strain (browse by keywords)

All proteins are shown (view only 495 complete proteome entries)

85 entries

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Select_allDeselect_all
AN_HHV8P Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
ARBH_HHV8P Apoptosis regulator Bcl-2 homolog
CEP3_HHV8P Cytoplasmic envelopment protein 3
CEP1_HHV8P Cytoplasmic envelopment protein 1
CEP2_HHV8P Cytoplasmic envelopment protein 2
CVC1_HHV8P Capsid vertex component 1
CVC2_HHV8P Capsid vertex component 2
DNBI_HHV8P Major DNA-binding protein
DUT_HHV8P Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DPOL_HHV8P DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
DYR_HHV8P Putative Dihydrofolate reductase (EC 1.5.1.3)
HELI_HHV8P DNA replication helicase (EC 3.6.4.-)
HEPA_HHV8P DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
GB_HHV8P Envelope glycoprotein B (gB)
GH_HHV8P Envelope glycoprotein H (gH)
GM_HHV8P Envelope glycoprotein M (gM)
GN_HHV8P Envelope glycoprotein N
GL_HHV8P Envelope glycoprotein L (gL)
ICP27_HHV8P mRNA export factor ICP27 homolog (EB2 protein homolog)
KITH_HHV8P Thymidine kinase (EC 2.7.1.21)
NEC2_HHV8P Nuclear egress protein 2
NEC1_HHV8P Nuclear egress protein 1
SCAF_HHV8P Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
SCP_HHV8P Small capsomere-interacting protein
TRM3_HHV8P Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRM2_HHV8P Tripartite terminase subunit 2
TRM1_HHV8P Tripartite terminase subunit 1
TRX1_HHV8P Triplex capsid protein 1
TYSY_HHV8P Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
TRX2_HHV8P Triplex capsid protein 2
UL24_HHV8P Protein UL24 homolog
UL92_HHV8P Protein ORF31
UL79_HHV8P Protein UL79 homolog
UL32_HHV8P Packaging protein UL32 homolog
VIRF4_HHV8P Viral IRF4-like protein (vIRF-4)
VMI2_HHV8P Viral macrophage inflammatory protein 2 (Viral macrophage inflammatory protein II) (vMIP-II) ...
VGPCR_HHV8P viral G-protein coupled receptor (vGPCR) (Protein ORF74)
VIRF2_HHV8P Viral IRF2-like protein (vIRF-2)
K15_HHV8P Protein K15
K42_HHV8P Protein K4.2
K7_HHV8P Protein K7
K1_HHV8P Protein K1
ITP_HHV8P Inner tegument protein
K12_HHV8P Protein K12
K6_HHV8P Protein K6
K81_HHV8P Protein K8.1
KBZIP_HHV8P E3 SUMO-protein ligase K-bZIP (EC 6.3.2.-)
LTP_HHV8P Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_HHV8P Major capsid protein (MCP)
MIR2_HHV8P E3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of immune recognition 2) ...
MIR1_HHV8P E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (IE1B protein) (Modulator of immune recognition 1) ...
ORF49_HHV8P Protein ORF49
ORF24_HHV8P Protein ORF24
ORF50_HHV8P Putative transcription activator ORF50
ORF27_HHV8P Protein ORF27
ORF28_HHV8P Protein ORF28
ORF30_HHV8P Protein ORF30
ORF45_HHV8P Protein ORF45
ORF4_HHV8P Complement control protein (KCP)
ORF48_HHV8P Tegument protein ORF48
ORF58_HHV8P Protein ORF58
OX2V_HHV8P OX-2 membrane glycoprotein homolog (Viral OX2) (vOX2)
ORF23_HHV8P Protein ORF23
ORF52_HHV8P Tegument protein ORF52
ORF73_HHV8P Protein ORF73
ORF10_HHV8P Protein ORF10
ORF35_HHV8P Protein ORF35
ORF75_HHV8P Protein ORF75
PAP_HHV8P DNA polymerase processivity factor
ORF11_HHV8P Protein ORF11
ORF36_HHV8P Protein ORF36 (EC 2.7.-.-)
PORTL_HHV8P Portal protein
PRIM_HHV8P DNA primase (EC 2.7.7.-)
RIR1_HHV8P Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_HHV8P Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
TEG7_HHV8P Tegument protein ORF55
VIL6_HHV8P Viral interleukin-6 homolog (vIL-6)
UL95_HHV8P Protein UL95 homolog
VIRF3_HHV8P Viral IRF3-like protein (VIRF-3)
VCYCL_HHV8P viral cyclin homolog (v-cyclin)
VFLIP_HHV8P Viral FLICE protein (vFLIP)
VCCL3_HHV8P Protein vCCL3
UL49_HHV8P Protein ORF66
UNG_HHV8P Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

76 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
AN_EBVB9 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BALF1_EBVB9 Apoptosis regulator BALF1
BDLF3_EBVB9 Glycoprotein BDLF3
BILF1_EBVB9 G-protein coupled receptor BILF1
BKRF4_EBVB9 Tegument protein BKRF4
BRRF2_EBVB9 Tegument protein BRRF2
BZLF1_EBVB9 Trans-activator protein BZLF1 (EB1) (Zebra)
BNL2B_EBVB9 Uncharacterized protein BNLF2b
BARF1_EBVB9 Secreted protein BARF1 (33 kDa early protein) (p33)
BTRF1_EBVB9 Uncharacterized protein BTRF1
BFRF2_EBVB9 Uncharacterized protein BFRF2
BILF2_EBVB9 Glycoprotein BILF2
BDLF2_EBVB9 Protein BDLF2
BLLF2_EBVB9 Uncharacterized protein BLLF2
BNL2A_EBVB9 Protein BNLF2a
BMRF2_EBVB9 Protein BMRF2
BHLF1_EBVB9 Uncharacterized protein BHLF1
BLRF2_EBVB9 Tegument protein BLRF2
BRRF1_EBVB9 Transcriptional activator BRRF1
CEP1_EBVB9 Cytoplasmic envelopment protein 1
CEP2_EBVB9 Cytoplasmic envelopment protein 2
CEP3_EBVB9 Cytoplasmic envelopment protein 3
CVC2_EBVB9 Capsid vertex component 2
CVC1_EBVB9 Capsid vertex component 1
DNBI_EBVB9 Major DNA-binding protein
EBNA2_EBVB9 Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
DUT_EBVB9 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EBNA1_EBVB9 Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
DPOL_EBVB9 DNA polymerase catalytic subunit (EC 2.7.7.7)
EBNA6_EBVB9 Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
EAR_EBVB9 Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
EBNA4_EBVB9 Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
EAD_EBVB9 DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
EBNA3_EBVB9 Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
EBNA5_EBVB9 Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
GL_EBVB9 Envelope glycoprotein L (gL)
GB_EBVB9 Envelope glycoprotein B (gB)
GH_EBVB9 Envelope glycoprotein H (gH)
GP350_EBVB9 Envelope glycoprotein GP350 (Membrane antigen) (MA)
GP42_EBVB9 Glycoprotein 42 (gp42) [Cleaved into: Soluble gp42]
GM_EBVB9 Envelope glycoprotein M (gM)
GN_EBVB9 Envelope glycoprotein N
ICP27_EBVB9 mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
IL10H_EBVB9 Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
KITH_EBVB9 Thymidine kinase (EC 2.7.1.21)
KR2_EBVB9 Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
NEC2_EBVB9 Nuclear egress protein 2
NEC1_EBVB9 Nuclear egress protein 1
RPMS1_EBVB9 Uncharacterized protein RPMS1
RTA_EBVB9 Replication and transcription activator (Rta) (Immediate-early protein Rta)
SCAF_EBVB9 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
SCP_EBVB9 Small capsomere-interacting protein
TRM1_EBVB9 Tripartite terminase subunit 1
TRM3_EBVB9 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_EBVB9 Triplex capsid protein 1
TRX2_EBVB9 Triplex capsid protein 2
UL24_EBVB9 Protein UL24 homolog
UL87_EBVB9 TBP-like protein BcRF1
UL32_EBVB9 Packaging protein UL32 homolog
UL92_EBVB9 Uncharacterized protein BDLF4
ITP_EBVB9 Inner tegument protein
LF2_EBVB9 Protein LF2
LF3_EBVB9 Uncharacterized protein LF3
LMP1_EBVB9 Latent membrane protein 1 (LMP-1) (Protein p63) [Cleaved into: Protein p25]
LF1_EBVB9 Uncharacterized LF1 protein
LMP2_EBVB9 Latent membrane protein 2 (Terminal protein)
LTP_EBVB9 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_EBVB9 Major capsid protein (MCP)
MTP_EBVB9 Major tegument protein (MTP) (Protein p140)
PRIM_EBVB9 DNA primase (EC 2.7.7.-)
PORTL_EBVB9 Portal protein
RIR1_EBVB9 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_EBVB9 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
TEG7_EBVB9 Tegument protein UL51 homolog
UL95_EBVB9 Protein BGLF3
UNG_EBVB9 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

75 entries

Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Select_allDeselect_all
AN_SHV21 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BRLF1_SHV21 Putative transcription activator BRLF1 homolog (Transcription activator EDRF1)
CCPH_SHV21 Complement control protein homolog (CCPH)
CD59_SHV21 Surface glycoprotein CD59 homolog
CEP1_SHV21 Cytoplasmic envelopment protein 1
CEP3_SHV21 Cytoplasmic envelopment protein 3
CGH2_SHV21 Cyclin homolog (V-cyclin)
CEP2_SHV21 Cytoplasmic envelopment protein 2
CVC2_SHV21 Capsid vertex component 2
CVC1_SHV21 Capsid vertex component 1
DNBI_SHV21 Major DNA-binding protein
DUT_SHV21 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DPOL_SHV21 DNA polymerase catalytic subunit (EC 2.7.7.7)
DYR_SHV21 Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
HELI_SHV21 DNA replication helicase (EC 3.6.4.-)
GB_SHV21 Envelope glycoprotein B (gB)
GCVK_SHV21 Probable ganciclovir kinase (EC 2.7.1.-)
GL_SHV21 Envelope glycoprotein L (gL)
GN_SHV21 Envelope glycoprotein N
GM_SHV21 Envelope glycoprotein M (gM)
GH_SHV21 Envelope glycoprotein H (gH)
ICP27_SHV21 mRNA export factor ICP27 homolog (52 kDa immediate-early phosphoprotein) (EB2 protein homolog)
ICP22_SHV21 Transcriptional regulator ICP22 homolog (Immediate-early protein)
IL17_SHV21 Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)
KITH_SHV21 Thymidine kinase (EC 2.7.1.21)
NEC2_SHV21 Nuclear egress protein 2
NEC1_SHV21 Nuclear egress protein 1
SCAF_SHV21 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
SCP_SHV21 Small capsomere-interacting protein
TRM3_SHV21 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRM1_SHV21 Tripartite terminase subunit 1
TRX2_SHV21 Triplex capsid protein 2
TRX1_SHV21 Triplex capsid protein 1
TSTP_SHV21 Transforming protein STP
UL32_SHV21 Packaging protein UL32
UL96_SHV21 Gene 35 protein
UL95_SHV21 Gene 34 protein
UNG_SHV21 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL49_SHV21 Uncharacterized gene 66 protein
UL92_SHV21 Gene 31 protein
VG11_SHV21 Uncharacterized gene 11 protein
VG49_SHV21 Uncharacterized gene 49 protein
VG40_SHV21 Uncharacterized gene 40 protein
VG41_SHV21 Uncharacterized gene 41 protein
VG51_SHV21 Gene 51 glycoprotein
VG10_SHV21 Uncharacterized gene 10 protein
VG45_SHV21 Uncharacterized gene 45 protein
VG52_SHV21 Uncharacterized gene 52 protein
VG71_SHV21 Uncharacterized gene 71 protein
VG74_SHV21 G-protein coupled receptor homolog ECRF3
VG23_SHV21 Uncharacterized gene 23 protein
VG48_SHV21 Uncharacterized gene 48 protein
VG59_SHV21 Gene 59 protein
VG58_SHV21 Gene 58 protein
VP75_SHV21 Probable membrane antigen 75 (Tegument protein)
ITP_SHV21 Inner tegument protein
LTP_SHV21 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_SHV21 Major capsid protein (MCP)
PORTL_SHV21 Portal protein
PRIM_SHV21 DNA primase (EC 2.7.7.-)
RIR2_SHV21 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RIR1_SHV21 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
TEG7_SHV21 Gene 55 protein
VG05_SHV21 Uncharacterized gene 5 protein
VIEG_SHV21 Immediate-early protein IE-G
UL87_SHV21 Gene 24 protein
VG12_SHV21 Uncharacterized gene 12 protein
UL24_SHV21 Protein UL24 homolog
VG27_SHV21 Uncharacterized gene 27 protein
VG28_SHV21 Uncharacterized gene 28 protein
TYSY_SHV21 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
VP03_SHV21 Probable membrane antigen 3 (Tegument protein)
VG16_SHV21 Bcl-2-like gene 16 protein
UL79_SHV21 Gene 18 protein
UL91_SHV21 Uncharacterized gene 30 protein

74 entries

Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

Select_allDeselect_all
AN_EHV2 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BRLF1_EHV2 Putative transcription activator BRLF1 homolog
CEP1_EHV2 Cytoplasmic envelopment protein 1
CEP2_EHV2 Cytoplasmic envelopment protein 2
CEP3_EHV2 Cytoplasmic envelopment protein 3
CFLA_EHV2 Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)
CVC2_EHV2 Capsid vertex component 2
CVC1_EHV2 Capsid vertex component 1
DNBI_EHV2 Major DNA-binding protein
DUT_EHV2 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DPOL_EHV2 DNA polymerase catalytic subunit (EC 2.7.7.7)
GN_EHV2 Envelope glycoprotein N
HEPA_EHV2 DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
HELI_EHV2 DNA replication helicase (EC 3.6.4.-)
GB_EHV2 Envelope glycoprotein B (gB)
GH_EHV2 Envelope glycoprotein H (gH)
GM_EHV2 Envelope glycoprotein M (gM)
GL_EHV2 Envelope glycoprotein L (gL)
IE63_EHV2 Immediate-early phosphoprotein 57
IL10H_EHV2 Viral interleukin-10 homolog (vIL-10)
NEC1_EHV2 Nuclear egress protein 1
NEC2_EHV2 Nuclear egress protein 2
SCAF_EHV2 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
SCP_EHV2 Small capsomere-interacting protein
TRM2_EHV2 Tripartite terminase subunit 2
TRM3_EHV2 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TYSY_EHV2 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
TRX1_EHV2 Triplex capsid protein 1
TRX2_EHV2 Triplex capsid protein 2
TRM1_EHV2 Tripartite terminase subunit 1
UL92_EHV2 Gene 31 protein
UL49_EHV2 Uncharacterized gene 66 protein
UL79_EHV2 Gene 18 protein
UL91_EHV2 Uncharacterized gene 30 protein
UL95_EHV2 Gene 34 protein
UL96_EHV2 Gene 35 protein
UL32_EHV2 Packaging protein UL32 homolog
UL24_EHV2 Protein UL24 homolog
VG48_EHV2 Tegument protein G48
VP03_EHV2 Probable membrane antigen 3 (Tegument protein)
VG27_EHV2 Uncharacterized gene 27 protein
VG59_EHV2 DNA polymerase processivity factor
VG12_EHV2 Protein E6A
VG49_EHV2 Uncharacterized gene 49 protein
VGE4_EHV2 Uncharacterized gene E4 protein
VG74_EHV2 G-protein coupled receptor 74
VGE3_EHV2 SUSHI domain-containing protein E3
VG45_EHV2 Uncharacterized gene 45 protein
VG58_EHV2 Gene 58 protein
VGE1_EHV2 G-protein coupled receptor E1
VG52_EHV2 Gene 52 protein
VG75_EHV2 Probable membrane antigen 75 (Tegument protein)
VGE2_EHV2 Uncharacterized gene E2 protein
VGE6_EHV2 G-protein coupled receptor E6
ITP_EHV2 Inner tegument protein
KITH_EHV2 Thymidine kinase (EC 2.7.1.21)
LTP_EHV2 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_EHV2 Major capsid protein (MCP)
PRIM_EHV2 DNA primase (EC 2.7.7.-)
PORTL_EHV2 Portal protein
RIR1_EHV2 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_EHV2 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
TEG7_EHV2 Tegument protein UL51 homolog
VG28_EHV2 Uncharacterized gene 28 protein
VG36_EHV2 Probable inactive protein kinase 38
UL87_EHV2 Gene 24 protein
VG10_EHV2 Uncharacterized gene 10 protein
VG13_EHV2 Protein E6C
VG51_EHV2 Putative C-type lectin protein 51
VGE9_EHV2 Uncharacterized gene E9 protein
VG11_EHV2 Uncharacterized gene 11 protein
VG23_EHV2 Uncharacterized gene 23 protein
VCLAP_EHV2 CARD domain-containing protein E10
UNG_EHV2 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

70 entries

Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

Select_allDeselect_all
AN_ALHV1 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BRLF1_ALHV1 Putative transcription activator BRLF1 homolog
CEP2_ALHV1 Cytoplasmic envelopment protein 2
CEP3_ALHV1 Cytoplasmic envelopment protein 3
CEP1_ALHV1 Cytoplasmic envelopment protein 1
CVC1_ALHV1 Capsid vertex component 1
CVC2_ALHV1 Capsid vertex component 2
DNBI_ALHV1 Major DNA-binding protein
DUT_ALHV1 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DPOL_ALHV1 DNA polymerase catalytic subunit (EC 2.7.7.7)
GM_ALHV1 Envelope glycoprotein M (gM)
HELI_ALHV1 DNA replication helicase (EC 3.6.4.-)
GH_ALHV1 Envelope glycoprotein H (gH)
GB_ALHV1 Envelope glycoprotein B (gB)
GN_ALHV1 Envelope glycoprotein N
GL_ALHV1 Envelope glycoprotein L (gL)
IE63_ALHV1 Immediate-early phosphoprotein 57
NEC2_ALHV1 Nuclear egress protein 2
NEC1_ALHV1 Nuclear egress protein 1
SCAF_ALHV1 Capsid scaffolding protein (Capsid protein 17) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
SEMA_ALHV1 Semaphorin-like protein A3
SCP_ALHV1 Small capsomere-interacting protein
TRM2_ALHV1 Tripartite terminase subunit 2
TRM3_ALHV1 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_ALHV1 Triplex capsid protein 1
TRM1_ALHV1 Tripartite terminase subunit 1
TRX2_ALHV1 Triplex capsid protein 2
UL87_ALHV1 Uncharacterized gene 24 protein
UL79_ALHV1 Gene 18 protein
UL92_ALHV1 Gene 31 protein
UL24_ALHV1 Protein UL24 homolog
UL49_ALHV1 Uncharacterized gene 66 protein
UL96_ALHV1 Gene 35 protein
UNG_ALHV1 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VG41_ALHV1 Uncharacterized gene 41 protein
VG11_ALHV1 Uncharacterized gene 11 protein
VG45_ALHV1 Uncharacterized gene 45 protein
VGA1_ALHV1 Uncharacterized gene A1 protein
VGA6_ALHV1 Uncharacterized gene A6 protein
VG40_ALHV1 Uncharacterized gene 40 protein
VG58_ALHV1 Gene 58 protein
VP03_ALHV1 Probable tegument protein antigen 3
VGA9_ALHV1 Putative apoptosis regulator A9
VGA10_ALHV1 Uncharacterized gene A10 protein
VGA5_ALHV1 G-protein coupled receptor A5
VG48_ALHV1 Uncharacterized gene 48 protein
VG73_ALHV1 Uncharacterized gene 73 protein
VGA2_ALHV1 Uncharacterized protein A2
VGA8_ALHV1 Uncharacterized gene A8 protein
VGA4_ALHV1 Uncharacterized gene A4 protein
VP75_ALHV1 Probable membrane antigen 75 (Tegument protein)
ITP_ALHV1 Inner tegument protein
KITH_ALHV1 Thymidine kinase (EC 2.7.1.21)
LTP_ALHV1 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_ALHV1 Major capsid protein (MCP)
PORTL_ALHV1 Portal protein
PRIM_ALHV1 DNA primase (EC 2.7.7.-)
RIR1_ALHV1 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_ALHV1 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
TEG7_ALHV1 Tegument protein UL51 homolog (Uncharacterized gene 55 protein)
UL32_ALHV1 Packaging protein UL32 homolog
UL91_ALHV1 Uncharacterized gene 30 protein
VG23_ALHV1 Uncharacterized gene 23 protein
VGA7_ALHV1 Putative C-type lectin protein A7
VG10_ALHV1 Uncharacterized gene 10 protein
VG27_ALHV1 Uncharacterized gene 27 protein
VG52_ALHV1 Uncharacterized gene 52 protein
VG36_ALHV1 Putative tyrosine kinase 36 (EC 2.7.10.2)
VG59_ALHV1 DNA polymerase processivity factor
UL95_ALHV1 Gene 34 protein

56 entries

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
AN_EBVA8 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BARF1_EBVA8 Secreted protein BARF1 (33 kDa early protein) (p33)
BDLF2_EBVA8 Protein BDLF2
BTRF1_EBVA8 Uncharacterized protein BTRF1
BLRF2_EBVA8 Tegument protein BLRF2
BMRF2_EBVA8 Protein BMRF2
BNL2A_EBVA8 Protein BNLF2a
BLLF2_EBVA8 Uncharacterized protein BLLF2
BKRF4_EBVA8 Tegument protein BKRF4
BNL2B_EBVA8 Uncharacterized protein BNLF2b
BRRF1_EBVA8 Transcriptional activator BRRF1
BRRF2_EBVA8 Tegument protein BRRF2
BZLF1_EBVA8 Trans-activator protein BZLF1 (EB1) (Zebra)
CEP3_EBVA8 Cytoplasmic envelopment protein 3
CEP2_EBVA8 Cytoplasmic envelopment protein 2
CEP1_EBVA8 Cytoplasmic envelopment protein 1
CVC2_EBVA8 Capsid vertex component 2
DNBI_EBVA8 Major DNA-binding protein
EAR_EBVA8 Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
EBNA1_EBVA8 Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
DPOL_EBVA8 DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_EBVA8 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EBNA3_EBVA8 Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
EBNA6_EBVA8 Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
EAD_EBVA8 DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
EBNA4_EBVA8 Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
EBNA5_EBVA8 Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
EBNA2_EBVA8 Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
GB_EBVA8 Envelope glycoprotein B (gB)
GH_EBVA8 Envelope glycoprotein H (gH)
GM_EBVA8 Envelope glycoprotein M (gM)
GL_EBVA8 Envelope glycoprotein L (gL)
GN_EBVA8 Envelope glycoprotein N
GP350_EBVA8 Envelope glycoprotein GP350 (Membrane antigen) (MA)
GP42_EBVA8 Glycoprotein 42 (gp42)
IL10H_EBVA8 Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
ICP27_EBVA8 mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
ITP_EBVA8 Inner tegument protein
KR2_EBVA8 Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
KITH_EBVA8 Thymidine kinase (EC 2.7.1.21)
NEC1_EBVA8 Nuclear egress protein 1
RTA_EBVA8 Replication and transcription activator (Rta) (Immediate-early protein Rta)
SCAF_EBVA8 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
TEG7_EBVA8 Tegument protein UL51 homolog
TRM3_EBVA8 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
UL92_EBVA8 Uncharacterized protein BDLF4
LMP1_EBVA8 Latent membrane protein 1 (LMP-1) (Protein p63)
LTP_EBVA8 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
LF1_EBVA8 Uncharacterized LF1 protein
LF2_EBVA8 Protein LF2
LMP2_EBVA8 Latent membrane protein 2 (Terminal protein)
MCP_EBVA8 Major capsid protein (MCP)
MTP_EBVA8 Major tegument protein (MTP) (Protein p140)
PORTL_EBVA8 Portal protein
RIR2_EBVA8 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RIR1_EBVA8 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...

2 entries

Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain

Select_allDeselect_all
LTP_MHV68 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MIR1_MHV68 E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (MK3) (Modulator of immune recognition 1 homolog) ...

3 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

Select_allDeselect_all
HELI_EBVB9 DNA replication helicase (EC 3.6.4.-)
YBL2_EBVB9 Uncharacterized protein BBLF2
YEC4_EBVB9 Uncharacterized protein EC-RF4

56 entries

Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Select_allDeselect_all
AN_EBVG Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BALF1_EBVG Apoptosis regulator BALF1
BLLF2_EBVG Uncharacterized protein BLLF2
BARF1_EBVG Secreted protein BARF1 (33 kDa early protein) (p33)
BMRF2_EBVG Protein BMRF2
BRRF1_EBVG Transcriptional activator BRRF1
BNL2A_EBVG Protein BNLF2a
BDLF2_EBVG Protein BDLF2
BZLF1_EBVG Trans-activator protein BZLF1 (EB1) (Zebra)
BLRF2_EBVG Tegument protein BLRF2
BNL2B_EBVG Uncharacterized protein BNLF2b
BRRF2_EBVG Tegument protein BRRF2
BKRF4_EBVG Tegument protein BKRF4
BTRF1_EBVG Uncharacterized protein BTRF1
CEP1_EBVG Cytoplasmic envelopment protein 1
CEP2_EBVG Cytoplasmic envelopment protein 2
CVC2_EBVG Capsid vertex component 2
DPOL_EBVG DNA polymerase catalytic subunit (EC 2.7.7.7)
DNBI_EBVG Major DNA-binding protein
EAR_EBVG Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
EBNA6_EBVG Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
EBNA2_EBVG Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
DUT_EBVG Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EBNA3_EBVG Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
EAD_EBVG DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
EBNA1_EBVG Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
EBNA5_EBVG Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
EBNA4_EBVG Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
GP350_EBVG Envelope glycoprotein GP350 (Membrane antigen) (MA)
GP42_EBVG Glycoprotein 42 (gp42) [Cleaved into: Soluble gp42]
GB_EBVG Envelope glycoprotein B (gB)
GH_EBVG Envelope glycoprotein H (gH)
GM_EBVG Envelope glycoprotein M (gM)
GL_EBVG Envelope glycoprotein L (gL)
GN_EBVG Envelope glycoprotein N
ICP27_EBVG mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
IL10H_EBVG Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
KITH_EBVG Thymidine kinase (EC 2.7.1.21)
LF3_EBVG Uncharacterized protein LF3
RPMS1_EBVG Uncharacterized protein RPMS1
SCAF_EBVG Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
RTA_EBVG Replication and transcription activator (Rta) (Immediate-early protein Rta)
TRM3_EBVG Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
ITP_EBVG Inner tegument protein
KR2_EBVG Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
LMP1_EBVG Latent membrane protein 1 (LMP-1) (Protein p63)
LF1_EBVG Uncharacterized LF1 protein
LF2_EBVG Protein LF2
LMP2_EBVG Latent membrane protein 2 (Terminal protein)
LTP_EBVG Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_EBVG Major capsid protein (MCP)
MTP_EBVG Major tegument protein (MTP) (Protein p140)
PORTL_EBVG Portal protein
RIR2_EBVG Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RIR1_EBVG Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
TEG7_EBVG Tegument protein UL51 homolog

6 entries

Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

Select_allDeselect_all
DYR_SHV2C Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
IL17_SHV2C Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)
STP_SHV2C Saimiri transformation-associated protein (Collagen-like protein) (stpC)
TIP_SHV2C Tyrosine-protein kinase-interacting protein (Tip)
YDH4_SHV2C Uncharacterized 9.9 kDa protein in DHFR 3'region (ORF4)
YDH3_SHV2C Uncharacterized 9.5 kDa protein in DHFR 3'region (ORF3)

3 entries

Bovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)

Select_allDeselect_all
BRLF1_BHV4D Putative transcription activator BRLF1 homolog
GCNT3_BHV4D Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...
VIE1_BHV4D Probable E3 ubiquitin-protein ligase IE1 (EC 2.3.2.27) (32.7 kDa immediate early protein IE1) ...

3 entries

Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)

Select_allDeselect_all
DYR_SHV24 Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
TIP_SHV24 Tyrosine-protein kinase-interacting protein (Tip)
STP_SHV24 Saimiri transformation-associated protein (Collagen-like protein) (stpC)

1 entry

Alcelaphine herpesvirus 1 (strain WC11) (AlHV-1) (Malignant catarrhal fever virus)

KITH_AHV1W Thymidine kinase (EC 2.7.1.21)

1 entry

Ateline herpesvirus 3 (AtHV-3) (Herpesvirus ateles)

TIO_ATHV3 Protein tio

1 entry

Bovine herpesvirus 4 (BoHV-4) (Movar virus)

GCNT3_BHV4 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Bovine herpesvirus 4 (strain LVR140) (BoHV-4) (Movar virus)

GCNT3_BHV4L Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Bovine herpesvirus 4 (strain V. test) (BoHV-4) (Movar virus)

GCNT3_BHV4V Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)

LMP1_EBVC Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Epstein-Barr virus (strain P3HR-1) (HHV-4) (Human herpesvirus 4)

VGP3_EBVP3 Envelope glycoprotein GP340 (Membrane antigen) (MA)

1 entry

Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

LMP1_EBVR Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Equine herpesvirus 2 (strain T400/3) (EHV-2)

IL10H_EHV2T Viral interleukin-10 homolog (vIL-10)

1 entry

Herpesvirus ateles

TYSY_HSVAT Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

1 entry

Saimiriine herpesvirus 2 (strain 484) (SaHV-2) (Herpesvirus saimiri)

TIP_SHV48 Tyrosine protein kinase-interacting protein (Tip) (TipC484)