Gammaherpesvirinae

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter,T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Gamma-herpesviruses have evolved different strategies to inhibit the host adaptive immune response. For example, the EHV-2 viral interleukin-10 homolog down-regulates the expression of the TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Apoptosis modulation

Apoptosis is very often modulated (and usually inhibited) by gamma-herpesviruses. For example, Epstein-Barr, HHV-8 or AlHV-1 all possess a viral homologue of the Bcl-2 oncogene that is able to protect cells from induced apoptosis.

Autophagy modulation

Several gamma-herpesviruses are able to inhibit host autophagy process, via interaction of vBcl-2 and vFLIP with host Beclin 1 and Atg3 respectively, that impact two stages of autophagy.

Cell-cycle modulation

The UL24 protein that is present in all herpesvirus subfamilies (alpha, beta and gamma-herpesviruses) induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

Herpes viruses inhibit the cascade leading to production of interferon-beta by mainly targeting the host IRF3 protein. EBV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the BGLF4 protein kinase that directly interacts with and inhibits host IRF3. BRLF1 expression also decreases induction of IFN-beta, and reduces expression of IRF3 and IRF7.

Host splicing inhibition

Modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

520 entries grouped by strain (browse by keywords)

All proteins are shown (view only 495 complete proteome entries)

85 entries

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Select_allDeselect_all
AN_HHV8P Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
ARBH_HHV8P Apoptosis regulator Bcl-2 homolog
CEP3_HHV8P Cytoplasmic envelopment protein 3
CEP1_HHV8P Cytoplasmic envelopment protein 1
CEP2_HHV8P Cytoplasmic envelopment protein 2
CVC2_HHV8P Capsid vertex component 2
CVC1_HHV8P Capsid vertex component 1
DUT_HHV8P Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DNBI_HHV8P Major DNA-binding protein
DPOL_HHV8P DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
DYR_HHV8P Putative Dihydrofolate reductase (EC 1.5.1.3)
GM_HHV8P Envelope glycoprotein M (gM)
GH_HHV8P Envelope glycoprotein H (gH)
GB_HHV8P Envelope glycoprotein B (gB)
GL_HHV8P Envelope glycoprotein L (gL)
GN_HHV8P Envelope glycoprotein N
LTP_HHV8P Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
NEC1_HHV8P Nuclear egress protein 1
PRIM_HHV8P DNA primase (EC 2.7.7.-)
SCP_HHV8P Small capsomere-interacting protein
SCAF_HHV8P Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
TEG7_HHV8P Tegument protein ORF55
HELI_HHV8P DNA replication helicase (EC 3.6.4.-)
HEPA_HHV8P DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
ICP27_HHV8P mRNA export factor ICP27 homolog (EB2 protein homolog)
K6_HHV8P Protein K6
K42_HHV8P Protein K4.2
K15_HHV8P Protein K15
K1_HHV8P Protein K1
K12_HHV8P Protein K12
K7_HHV8P Protein K7
K81_HHV8P Protein K8.1
ITP_HHV8P Inner tegument protein
KBZIP_HHV8P E3 SUMO-protein ligase K-bZIP (EC 6.3.2.-)
KITH_HHV8P Thymidine kinase (EC 2.7.1.21)
MCP_HHV8P Major capsid protein (MCP)
MIR2_HHV8P E3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of immune recognition 2) ...
MIR1_HHV8P E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (IE1B protein) (Modulator of immune recognition 1) ...
NEC2_HHV8P Nuclear egress protein 2
ORF58_HHV8P Protein ORF58
ORF75_HHV8P Protein ORF75
ORF11_HHV8P Protein ORF11
ORF45_HHV8P Protein ORF45
ORF28_HHV8P Protein ORF28
ORF52_HHV8P Tegument protein ORF52
ORF30_HHV8P Protein ORF30
ORF48_HHV8P Tegument protein ORF48
ORF50_HHV8P Putative transcription activator ORF50
ORF10_HHV8P Protein ORF10
ORF24_HHV8P Protein ORF24
ORF35_HHV8P Protein ORF35
ORF36_HHV8P Protein ORF36 (EC 2.7.-.-)
ORF73_HHV8P Protein ORF73
PAP_HHV8P DNA polymerase processivity factor
ORF49_HHV8P Protein ORF49
ORF4_HHV8P Complement control protein (KCP)
OX2V_HHV8P OX-2 membrane glycoprotein homolog (Viral OX2) (vOX2)
ORF23_HHV8P Protein ORF23
ORF27_HHV8P Protein ORF27
PORTL_HHV8P Portal protein
RIR1_HHV8P Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_HHV8P Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
TRM3_HHV8P Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX2_HHV8P Triplex capsid protein 2
TRM2_HHV8P Tripartite terminase subunit 2
TYSY_HHV8P Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
TRM1_HHV8P Tripartite terminase subunit 1
TRX1_HHV8P Triplex capsid protein 1
UL32_HHV8P Packaging protein UL32 homolog
VIRF4_HHV8P Viral IRF4-like protein (vIRF-4)
VCYCL_HHV8P viral cyclin homolog (v-cyclin)
VFLIP_HHV8P Viral FLICE protein (vFLIP)
UL24_HHV8P Protein UL24 homolog
UNG_HHV8P Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL79_HHV8P Protein UL79 homolog
UL95_HHV8P Protein UL95 homolog
VIRF2_HHV8P Viral IRF2-like protein (vIRF-2)
UL49_HHV8P Protein ORF66
VIL6_HHV8P Viral interleukin-6 homolog (vIL-6)
UL92_HHV8P Protein ORF31
VIRF3_HHV8P Viral IRF3-like protein (VIRF-3)
VGPCR_HHV8P viral G-protein coupled receptor (vGPCR) (Protein ORF74)
VMI2_HHV8P Viral macrophage inflammatory protein 2 (Viral macrophage inflammatory protein II) (vMIP-II) ...
VCCL3_HHV8P Protein vCCL3

76 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
AN_EBVB9 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BFRF2_EBVB9 Uncharacterized protein BFRF2
BHLF1_EBVB9 Uncharacterized protein BHLF1
BARF1_EBVB9 Secreted protein BARF1 (33 kDa early protein) (p33)
BILF2_EBVB9 Glycoprotein BILF2
BALF1_EBVB9 Apoptosis regulator BALF1
BDLF2_EBVB9 Protein BDLF2
BNL2A_EBVB9 Protein BNLF2a
BDLF3_EBVB9 Glycoprotein BDLF3
BKRF4_EBVB9 Tegument protein BKRF4
BNL2B_EBVB9 Uncharacterized protein BNLF2b
BRRF1_EBVB9 Transcriptional activator BRRF1
BILF1_EBVB9 G-protein coupled receptor BILF1
BLLF2_EBVB9 Uncharacterized protein BLLF2
BLRF2_EBVB9 Tegument protein BLRF2
BRRF2_EBVB9 Tegument protein BRRF2
BMRF2_EBVB9 Protein BMRF2
BTRF1_EBVB9 Uncharacterized protein BTRF1
BZLF1_EBVB9 Trans-activator protein BZLF1 (EB1) (Zebra)
CEP2_EBVB9 Cytoplasmic envelopment protein 2
CEP1_EBVB9 Cytoplasmic envelopment protein 1
CEP3_EBVB9 Cytoplasmic envelopment protein 3
CVC2_EBVB9 Capsid vertex component 2
CVC1_EBVB9 Capsid vertex component 1
DNBI_EBVB9 Major DNA-binding protein
EAR_EBVB9 Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
EBNA4_EBVB9 Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
EBNA5_EBVB9 Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
DPOL_EBVB9 DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_EBVB9 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EBNA1_EBVB9 Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
EAD_EBVB9 DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
EBNA6_EBVB9 Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
EBNA3_EBVB9 Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
EBNA2_EBVB9 Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
GH_EBVB9 Envelope glycoprotein H (gH)
GB_EBVB9 Envelope glycoprotein B (gB)
GL_EBVB9 Envelope glycoprotein L (gL)
GN_EBVB9 Envelope glycoprotein N
GP350_EBVB9 Envelope glycoprotein GP350 (Membrane antigen) (MA)
GP42_EBVB9 Glycoprotein 42 (gp42) [Cleaved into: Soluble gp42]
GM_EBVB9 Envelope glycoprotein M (gM)
LMP2_EBVB9 Latent membrane protein 2 (Terminal protein)
LTP_EBVB9 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
NEC2_EBVB9 Nuclear egress protein 2
NEC1_EBVB9 Nuclear egress protein 1
PORTL_EBVB9 Portal protein
PRIM_EBVB9 DNA primase (EC 2.7.7.-)
SCP_EBVB9 Small capsomere-interacting protein
SCAF_EBVB9 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
TEG7_EBVB9 Tegument protein UL51 homolog
ICP27_EBVB9 mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
IL10H_EBVB9 Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
ITP_EBVB9 Inner tegument protein
LMP1_EBVB9 Latent membrane protein 1 (LMP-1) (Protein p63) [Cleaved into: Protein p25]
LF1_EBVB9 Uncharacterized LF1 protein
LF2_EBVB9 Protein LF2
KITH_EBVB9 Thymidine kinase (EC 2.7.1.21)
KR2_EBVB9 Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
LF3_EBVB9 Uncharacterized protein LF3
MCP_EBVB9 Major capsid protein (MCP)
MTP_EBVB9 Major tegument protein (MTP) (Protein p140)
RIR1_EBVB9 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_EBVB9 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RPMS1_EBVB9 Uncharacterized protein RPMS1
RTA_EBVB9 Replication and transcription activator (Rta) (Immediate-early protein Rta)
TRM3_EBVB9 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_EBVB9 Triplex capsid protein 1
TRM1_EBVB9 Tripartite terminase subunit 1
TRX2_EBVB9 Triplex capsid protein 2
UNG_EBVB9 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL87_EBVB9 TBP-like protein BcRF1
UL95_EBVB9 Protein BGLF3
UL24_EBVB9 Protein UL24 homolog
UL32_EBVB9 Packaging protein UL32 homolog
UL92_EBVB9 Uncharacterized protein BDLF4

75 entries

Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Select_allDeselect_all
AN_SHV21 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BRLF1_SHV21 Putative transcription activator BRLF1 homolog (Transcription activator EDRF1)
CEP2_SHV21 Cytoplasmic envelopment protein 2
CEP3_SHV21 Cytoplasmic envelopment protein 3
CCPH_SHV21 Complement control protein homolog (CCPH)
CD59_SHV21 Surface glycoprotein CD59 homolog
CGH2_SHV21 Cyclin homolog (V-cyclin)
CEP1_SHV21 Cytoplasmic envelopment protein 1
CVC2_SHV21 Capsid vertex component 2
CVC1_SHV21 Capsid vertex component 1
DNBI_SHV21 Major DNA-binding protein
DPOL_SHV21 DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_SHV21 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DYR_SHV21 Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
GCVK_SHV21 Probable ganciclovir kinase (EC 2.7.1.-)
GB_SHV21 Envelope glycoprotein B (gB)
GH_SHV21 Envelope glycoprotein H (gH)
GN_SHV21 Envelope glycoprotein N
GL_SHV21 Envelope glycoprotein L (gL)
GM_SHV21 Envelope glycoprotein M (gM)
HELI_SHV21 DNA replication helicase (EC 3.6.4.-)
LTP_SHV21 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
NEC1_SHV21 Nuclear egress protein 1
NEC2_SHV21 Nuclear egress protein 2
PRIM_SHV21 DNA primase (EC 2.7.7.-)
PORTL_SHV21 Portal protein
SCAF_SHV21 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
SCP_SHV21 Small capsomere-interacting protein
TEG7_SHV21 Gene 55 protein
ICP22_SHV21 Transcriptional regulator ICP22 homolog (Immediate-early protein)
ICP27_SHV21 mRNA export factor ICP27 homolog (52 kDa immediate-early phosphoprotein) (EB2 protein homolog)
ITP_SHV21 Inner tegument protein
IL17_SHV21 Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)
KITH_SHV21 Thymidine kinase (EC 2.7.1.21)
MCP_SHV21 Major capsid protein (MCP)
RIR1_SHV21 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_SHV21 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
TYSY_SHV21 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
TRM1_SHV21 Tripartite terminase subunit 1
TRM3_SHV21 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_SHV21 Triplex capsid protein 1
TRX2_SHV21 Triplex capsid protein 2
UNG_SHV21 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL96_SHV21 Gene 35 protein
TSTP_SHV21 Transforming protein STP
UL79_SHV21 Gene 18 protein
UL87_SHV21 Gene 24 protein
VG23_SHV21 Uncharacterized gene 23 protein
VG45_SHV21 Uncharacterized gene 45 protein
VG51_SHV21 Gene 51 glycoprotein
VG59_SHV21 Gene 59 protein
UL49_SHV21 Uncharacterized gene 66 protein
UL32_SHV21 Packaging protein UL32
UL92_SHV21 Gene 31 protein
VG12_SHV21 Uncharacterized gene 12 protein
VG16_SHV21 Bcl-2-like gene 16 protein
VG48_SHV21 Uncharacterized gene 48 protein
VG10_SHV21 Uncharacterized gene 10 protein
VG27_SHV21 Uncharacterized gene 27 protein
VG28_SHV21 Uncharacterized gene 28 protein
VG58_SHV21 Gene 58 protein
VG05_SHV21 Uncharacterized gene 5 protein
VG71_SHV21 Uncharacterized gene 71 protein
VG74_SHV21 G-protein coupled receptor homolog ECRF3
UL24_SHV21 Protein UL24 homolog
UL91_SHV21 Uncharacterized gene 30 protein
UL95_SHV21 Gene 34 protein
VG40_SHV21 Uncharacterized gene 40 protein
VG41_SHV21 Uncharacterized gene 41 protein
VP75_SHV21 Probable membrane antigen 75 (Tegument protein)
VG11_SHV21 Uncharacterized gene 11 protein
VG49_SHV21 Uncharacterized gene 49 protein
VIEG_SHV21 Immediate-early protein IE-G
VP03_SHV21 Probable membrane antigen 3 (Tegument protein)
VG52_SHV21 Uncharacterized gene 52 protein

74 entries

Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

Select_allDeselect_all
AN_EHV2 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BRLF1_EHV2 Putative transcription activator BRLF1 homolog
CEP1_EHV2 Cytoplasmic envelopment protein 1
CEP2_EHV2 Cytoplasmic envelopment protein 2
CEP3_EHV2 Cytoplasmic envelopment protein 3
CFLA_EHV2 Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)
CVC2_EHV2 Capsid vertex component 2
CVC1_EHV2 Capsid vertex component 1
DNBI_EHV2 Major DNA-binding protein
DPOL_EHV2 DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_EHV2 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
GM_EHV2 Envelope glycoprotein M (gM)
GL_EHV2 Envelope glycoprotein L (gL)
GH_EHV2 Envelope glycoprotein H (gH)
GB_EHV2 Envelope glycoprotein B (gB)
GN_EHV2 Envelope glycoprotein N
HEPA_EHV2 DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
LTP_EHV2 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
NEC1_EHV2 Nuclear egress protein 1
PORTL_EHV2 Portal protein
PRIM_EHV2 DNA primase (EC 2.7.7.-)
SCAF_EHV2 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
SCP_EHV2 Small capsomere-interacting protein
TEG7_EHV2 Tegument protein UL51 homolog
HELI_EHV2 DNA replication helicase (EC 3.6.4.-)
IE63_EHV2 Immediate-early phosphoprotein 57
IL10H_EHV2 Viral interleukin-10 homolog (vIL-10)
ITP_EHV2 Inner tegument protein
KITH_EHV2 Thymidine kinase (EC 2.7.1.21)
MCP_EHV2 Major capsid protein (MCP)
NEC2_EHV2 Nuclear egress protein 2
RIR2_EHV2 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RIR1_EHV2 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
TYSY_EHV2 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
TRX1_EHV2 Triplex capsid protein 1
TRM3_EHV2 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRM1_EHV2 Tripartite terminase subunit 1
TRM2_EHV2 Tripartite terminase subunit 2
TRX2_EHV2 Triplex capsid protein 2
UL24_EHV2 Protein UL24 homolog
UL87_EHV2 Gene 24 protein
UL92_EHV2 Gene 31 protein
UL49_EHV2 Uncharacterized gene 66 protein
UL79_EHV2 Gene 18 protein
UL91_EHV2 Uncharacterized gene 30 protein
VG28_EHV2 Uncharacterized gene 28 protein
VGE1_EHV2 G-protein coupled receptor E1
UL96_EHV2 Gene 35 protein
VG10_EHV2 Uncharacterized gene 10 protein
UL95_EHV2 Gene 34 protein
VG12_EHV2 Protein E6A
VG13_EHV2 Protein E6C
VG27_EHV2 Uncharacterized gene 27 protein
VG45_EHV2 Uncharacterized gene 45 protein
VG59_EHV2 DNA polymerase processivity factor
VG75_EHV2 Probable membrane antigen 75 (Tegument protein)
VGE2_EHV2 Uncharacterized gene E2 protein
VGE9_EHV2 Uncharacterized gene E9 protein
VGE3_EHV2 SUSHI domain-containing protein E3
UNG_EHV2 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL32_EHV2 Packaging protein UL32 homolog
VCLAP_EHV2 CARD domain-containing protein E10
VG52_EHV2 Gene 52 protein
VG74_EHV2 G-protein coupled receptor 74
VG11_EHV2 Uncharacterized gene 11 protein
VG23_EHV2 Uncharacterized gene 23 protein
VG36_EHV2 Probable inactive protein kinase 38
VG48_EHV2 Tegument protein G48
VG49_EHV2 Uncharacterized gene 49 protein
VG51_EHV2 Putative C-type lectin protein 51
VG58_EHV2 Gene 58 protein
VGE4_EHV2 Uncharacterized gene E4 protein
VGE6_EHV2 G-protein coupled receptor E6
VP03_EHV2 Probable membrane antigen 3 (Tegument protein)

70 entries

Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

Select_allDeselect_all
AN_ALHV1 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BRLF1_ALHV1 Putative transcription activator BRLF1 homolog
CEP2_ALHV1 Cytoplasmic envelopment protein 2
CEP3_ALHV1 Cytoplasmic envelopment protein 3
CEP1_ALHV1 Cytoplasmic envelopment protein 1
CVC1_ALHV1 Capsid vertex component 1
CVC2_ALHV1 Capsid vertex component 2
DNBI_ALHV1 Major DNA-binding protein
DUT_ALHV1 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DPOL_ALHV1 DNA polymerase catalytic subunit (EC 2.7.7.7)
GH_ALHV1 Envelope glycoprotein H (gH)
GB_ALHV1 Envelope glycoprotein B (gB)
GN_ALHV1 Envelope glycoprotein N
GL_ALHV1 Envelope glycoprotein L (gL)
GM_ALHV1 Envelope glycoprotein M (gM)
NEC2_ALHV1 Nuclear egress protein 2
PORTL_ALHV1 Portal protein
PRIM_ALHV1 DNA primase (EC 2.7.7.-)
SCAF_ALHV1 Capsid scaffolding protein (Capsid protein 17) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
SEMA_ALHV1 Semaphorin-like protein A3
SCP_ALHV1 Small capsomere-interacting protein
TEG7_ALHV1 Tegument protein UL51 homolog (Uncharacterized gene 55 protein)
TRM1_ALHV1 Tripartite terminase subunit 1
HELI_ALHV1 DNA replication helicase (EC 3.6.4.-)
IE63_ALHV1 Immediate-early phosphoprotein 57
KITH_ALHV1 Thymidine kinase (EC 2.7.1.21)
ITP_ALHV1 Inner tegument protein
LTP_ALHV1 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_ALHV1 Major capsid protein (MCP)
NEC1_ALHV1 Nuclear egress protein 1
RIR2_ALHV1 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RIR1_ALHV1 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
TRM2_ALHV1 Tripartite terminase subunit 2
TRX1_ALHV1 Triplex capsid protein 1
TRM3_ALHV1 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX2_ALHV1 Triplex capsid protein 2
UL49_ALHV1 Uncharacterized gene 66 protein
UL24_ALHV1 Protein UL24 homolog
UL87_ALHV1 Uncharacterized gene 24 protein
VG23_ALHV1 Uncharacterized gene 23 protein
VG45_ALHV1 Uncharacterized gene 45 protein
VG59_ALHV1 DNA polymerase processivity factor
VGA1_ALHV1 Uncharacterized gene A1 protein
UL32_ALHV1 Packaging protein UL32 homolog
UL95_ALHV1 Gene 34 protein
UNG_ALHV1 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VG36_ALHV1 Putative tyrosine kinase 36 (EC 2.7.10.2)
VG48_ALHV1 Uncharacterized gene 48 protein
UL79_ALHV1 Gene 18 protein
UL92_ALHV1 Gene 31 protein
UL96_ALHV1 Gene 35 protein
VG40_ALHV1 Uncharacterized gene 40 protein
VG52_ALHV1 Uncharacterized gene 52 protein
VG73_ALHV1 Uncharacterized gene 73 protein
VGA4_ALHV1 Uncharacterized gene A4 protein
VGA7_ALHV1 Putative C-type lectin protein A7
VP75_ALHV1 Probable membrane antigen 75 (Tegument protein)
VP03_ALHV1 Probable tegument protein antigen 3
UL91_ALHV1 Uncharacterized gene 30 protein
VG10_ALHV1 Uncharacterized gene 10 protein
VG58_ALHV1 Gene 58 protein
VGA9_ALHV1 Putative apoptosis regulator A9
VG11_ALHV1 Uncharacterized gene 11 protein
VG27_ALHV1 Uncharacterized gene 27 protein
VGA2_ALHV1 Uncharacterized protein A2
VGA8_ALHV1 Uncharacterized gene A8 protein
VG41_ALHV1 Uncharacterized gene 41 protein
VGA10_ALHV1 Uncharacterized gene A10 protein
VGA6_ALHV1 Uncharacterized gene A6 protein
VGA5_ALHV1 G-protein coupled receptor A5

56 entries

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
AN_EBVA8 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BLLF2_EBVA8 Uncharacterized protein BLLF2
BNL2A_EBVA8 Protein BNLF2a
BLRF2_EBVA8 Tegument protein BLRF2
BDLF2_EBVA8 Protein BDLF2
BMRF2_EBVA8 Protein BMRF2
BRRF2_EBVA8 Tegument protein BRRF2
BARF1_EBVA8 Secreted protein BARF1 (33 kDa early protein) (p33)
BNL2B_EBVA8 Uncharacterized protein BNLF2b
BRRF1_EBVA8 Transcriptional activator BRRF1
BKRF4_EBVA8 Tegument protein BKRF4
BZLF1_EBVA8 Trans-activator protein BZLF1 (EB1) (Zebra)
BTRF1_EBVA8 Uncharacterized protein BTRF1
CEP3_EBVA8 Cytoplasmic envelopment protein 3
CEP1_EBVA8 Cytoplasmic envelopment protein 1
CEP2_EBVA8 Cytoplasmic envelopment protein 2
CVC2_EBVA8 Capsid vertex component 2
DNBI_EBVA8 Major DNA-binding protein
DPOL_EBVA8 DNA polymerase catalytic subunit (EC 2.7.7.7)
EBNA3_EBVA8 Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
DUT_EBVA8 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EAD_EBVA8 DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
EBNA5_EBVA8 Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
EBNA6_EBVA8 Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
EAR_EBVA8 Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
EBNA1_EBVA8 Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
EBNA2_EBVA8 Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
EBNA4_EBVA8 Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
GM_EBVA8 Envelope glycoprotein M (gM)
GH_EBVA8 Envelope glycoprotein H (gH)
GB_EBVA8 Envelope glycoprotein B (gB)
GP42_EBVA8 Glycoprotein 42 (gp42)
GN_EBVA8 Envelope glycoprotein N
GL_EBVA8 Envelope glycoprotein L (gL)
GP350_EBVA8 Envelope glycoprotein GP350 (Membrane antigen) (MA)
LF1_EBVA8 Uncharacterized LF1 protein
LMP1_EBVA8 Latent membrane protein 1 (LMP-1) (Protein p63)
LMP2_EBVA8 Latent membrane protein 2 (Terminal protein)
LTP_EBVA8 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
NEC1_EBVA8 Nuclear egress protein 1
PORTL_EBVA8 Portal protein
RTA_EBVA8 Replication and transcription activator (Rta) (Immediate-early protein Rta)
SCAF_EBVA8 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
TEG7_EBVA8 Tegument protein UL51 homolog
ICP27_EBVA8 mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
IL10H_EBVA8 Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
ITP_EBVA8 Inner tegument protein
KR2_EBVA8 Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
KITH_EBVA8 Thymidine kinase (EC 2.7.1.21)
LF2_EBVA8 Protein LF2
MCP_EBVA8 Major capsid protein (MCP)
MTP_EBVA8 Major tegument protein (MTP) (Protein p140)
RIR2_EBVA8 Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RIR1_EBVA8 Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
TRM3_EBVA8 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
UL92_EBVA8 Uncharacterized protein BDLF4

2 entries

Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain

Select_allDeselect_all
LTP_MHV68 Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MIR1_MHV68 E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (MK3) (Modulator of immune recognition 1 homolog) ...

3 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

Select_allDeselect_all
YBL2_EBVB9 Uncharacterized protein BBLF2
YEC4_EBVB9 Uncharacterized protein EC-RF4
HELI_EBVB9 DNA replication helicase (EC 3.6.4.-)

56 entries

Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Select_allDeselect_all
AN_EBVG Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BALF1_EBVG Apoptosis regulator BALF1
BDLF2_EBVG Protein BDLF2
BMRF2_EBVG Protein BMRF2
BLLF2_EBVG Uncharacterized protein BLLF2
BRRF2_EBVG Tegument protein BRRF2
BTRF1_EBVG Uncharacterized protein BTRF1
BLRF2_EBVG Tegument protein BLRF2
BNL2A_EBVG Protein BNLF2a
BKRF4_EBVG Tegument protein BKRF4
BARF1_EBVG Secreted protein BARF1 (33 kDa early protein) (p33)
BZLF1_EBVG Trans-activator protein BZLF1 (EB1) (Zebra)
BRRF1_EBVG Transcriptional activator BRRF1
BNL2B_EBVG Uncharacterized protein BNLF2b
CEP1_EBVG Cytoplasmic envelopment protein 1
CEP2_EBVG Cytoplasmic envelopment protein 2
CVC2_EBVG Capsid vertex component 2
DPOL_EBVG DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_EBVG Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DNBI_EBVG Major DNA-binding protein
EAD_EBVG DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory ...
EBNA6_EBVG Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) ...
EAR_EBVG Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
EBNA3_EBVG Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) ...
EBNA4_EBVG Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) ...
EBNA5_EBVG Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) ...
EBNA1_EBVG Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
EBNA2_EBVG Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
GB_EBVG Envelope glycoprotein B (gB)
GL_EBVG Envelope glycoprotein L (gL)
GM_EBVG Envelope glycoprotein M (gM)
GH_EBVG Envelope glycoprotein H (gH)
GP350_EBVG Envelope glycoprotein GP350 (Membrane antigen) (MA)
GP42_EBVG Glycoprotein 42 (gp42) [Cleaved into: Soluble gp42]
GN_EBVG Envelope glycoprotein N
LMP2_EBVG Latent membrane protein 2 (Terminal protein)
LTP_EBVG Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
LF3_EBVG Uncharacterized protein LF3
LF2_EBVG Protein LF2
LMP1_EBVG Latent membrane protein 1 (LMP-1) (Protein p63)
PORTL_EBVG Portal protein
RTA_EBVG Replication and transcription activator (Rta) (Immediate-early protein Rta)
SCAF_EBVG Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) ...
TEG7_EBVG Tegument protein UL51 homolog
ICP27_EBVG mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
IL10H_EBVG Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
KITH_EBVG Thymidine kinase (EC 2.7.1.21)
ITP_EBVG Inner tegument protein
KR2_EBVG Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
LF1_EBVG Uncharacterized LF1 protein
MCP_EBVG Major capsid protein (MCP)
MTP_EBVG Major tegument protein (MTP) (Protein p140)
RIR1_EBVG Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
RIR2_EBVG Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RPMS1_EBVG Uncharacterized protein RPMS1
TRM3_EBVG Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

6 entries

Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

Select_allDeselect_all
DYR_SHV2C Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
TIP_SHV2C Tyrosine-protein kinase-interacting protein (Tip)
IL17_SHV2C Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)
STP_SHV2C Saimiri transformation-associated protein (Collagen-like protein) (stpC)
YDH3_SHV2C Uncharacterized 9.5 kDa protein in DHFR 3'region (ORF3)
YDH4_SHV2C Uncharacterized 9.9 kDa protein in DHFR 3'region (ORF4)

3 entries

Bovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)

Select_allDeselect_all
BRLF1_BHV4D Putative transcription activator BRLF1 homolog
GCNT3_BHV4D Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...
VIE1_BHV4D Probable E3 ubiquitin-protein ligase IE1 (EC 2.3.2.27) (32.7 kDa immediate early protein IE1) ...

3 entries

Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)

Select_allDeselect_all
DYR_SHV24 Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
TIP_SHV24 Tyrosine-protein kinase-interacting protein (Tip)
STP_SHV24 Saimiri transformation-associated protein (Collagen-like protein) (stpC)

1 entry

Alcelaphine herpesvirus 1 (strain WC11) (AlHV-1) (Malignant catarrhal fever virus)

KITH_AHV1W Thymidine kinase (EC 2.7.1.21)

1 entry

Ateline herpesvirus 3 (AtHV-3) (Herpesvirus ateles)

TIO_ATHV3 Protein tio

1 entry

Bovine herpesvirus 4 (BoHV-4) (Movar virus)

GCNT3_BHV4 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Bovine herpesvirus 4 (strain LVR140) (BoHV-4) (Movar virus)

GCNT3_BHV4L Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Bovine herpesvirus 4 (strain V. test) (BoHV-4) (Movar virus)

GCNT3_BHV4V Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) ...

1 entry

Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)

LMP1_EBVC Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Epstein-Barr virus (strain P3HR-1) (HHV-4) (Human herpesvirus 4)

VGP3_EBVP3 Envelope glycoprotein GP340 (Membrane antigen) (MA)

1 entry

Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

LMP1_EBVR Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Equine herpesvirus 2 (strain T400/3) (EHV-2)

IL10H_EHV2T Viral interleukin-10 homolog (vIL-10)

1 entry

Herpesvirus ateles

TYSY_HSVAT Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

1 entry

Saimiriine herpesvirus 2 (strain 484) (SaHV-2) (Herpesvirus saimiri)

TIP_SHV48 Tyrosine protein kinase-interacting protein (Tip) (TipC484)