Deltapapillomavirus

VIRION

Non-enveloped. Small, icosahedral, about 60 nm in size. A single molecule of circular dsDNA is contained within the capsid, which is composed of 72 pentamers arranged on a T = 7 lattice.

GENOME

Circular dsDNA, about 8 kb in size, associated with cellular histones.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.

GENE EXPRESSION

Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing :
a) Early Proteins: non-structural regulatory proteins (E1-E7).
b) Late Proteins: the structural proteins L1 and L2.

REPLICATION

NUCLEAR

Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.

b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.

  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.

Matching UniProtKB/Swiss-Prot entries

35 entries grouped by protein (browse by keywords)

All proteins are shown (view only 34 complete proteome entries)

4 entries

Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)

Select_allDeselect_all
VE1_BPV1
Bovine papillomavirus type 1 reference strain
VE1_PAPVE
European elk papillomavirus (EEPV) reference strain
VE1_BPV2
Bovine papillomavirus type 2
VE1_PAPVD
Deer papillomavirus (DPV) (Deer fibroma virus)

4 entries

Regulatory protein E2

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VE2_BPV1
Bovine papillomavirus type 1 reference strain
VE2_PAPVE
European elk papillomavirus (EEPV) reference strain
VE2_BPV2
Bovine papillomavirus type 2
VE2_PAPVD
Deer papillomavirus (DPV) (Deer fibroma virus)

1 entry

Probable protein E3

VE3_BPV2
Bovine papillomavirus type 2

3 entries

Probable protein E4

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VE4_BPV1
Bovine papillomavirus type 1 reference strain

Protein E4

VE4_BPV2
Bovine papillomavirus type 2
VE4_PAPVD
Deer papillomavirus (DPV) (Deer fibroma virus)

4 entries

Protein E5

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VE5_BPV1
Bovine papillomavirus type 1 reference strain
VE5_PAPVE
European elk papillomavirus (EEPV) reference strain
VE5_BPV2
Bovine papillomavirus type 2
VE5_PAPVR
Reindeer papillomavirus (RPV)

4 entries

Protein E6

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VE6_BPV1
Bovine papillomavirus type 1 reference strain
VE6_PAPVE
European elk papillomavirus (EEPV) reference strain
VE6_BPV2
Bovine papillomavirus type 2
VE6_PAPVD
Deer papillomavirus (DPV) (Deer fibroma virus)

4 entries

Protein E7

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VE7_BPV1
Bovine papillomavirus type 1 reference strain
VE7_PAPVE
European elk papillomavirus (EEPV) reference strain
VE7_BPV2
Bovine papillomavirus type 2
VE7_PAPVD
Deer papillomavirus (DPV) (Deer fibroma virus)

1 entry

Uncharacterized protein E8

VE8_BPV2
Bovine papillomavirus type 2

1 entry

Protein E8^E2C

VE8E2_BPV1
Bovine papillomavirus type 1 reference strain

4 entries

Major capsid protein L1

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VL1_BPV1
Bovine papillomavirus type 1 reference strain
VL1_PAPVE
European elk papillomavirus (EEPV) reference strain
VL1_BPV2
Bovine papillomavirus type 2
VL1_PAPVD
Deer papillomavirus (DPV) (Deer fibroma virus)

4 entries

Minor capsid protein L2

Select_allDeselect_all
VL2_BPV1
Bovine papillomavirus type 1 reference strain
VL2_PAPVE
European elk papillomavirus (EEPV) reference strain
VL2_BPV2
Bovine papillomavirus type 2
VL2_PAPVD
Deer papillomavirus (DPV) (Deer fibroma virus)

1 entry

Probable protein L3

VL3_PAPVD
Deer papillomavirus (DPV) (Deer fibroma virus)