Vesivirus

VIRION

Non-enveloped, capsid of about 38-40 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 VP1 proteins. Small empty virions are about 23nm in diameter, and would be of T=1 icosahedral symmetry, composed of 60 VP1 proteins.

GENOME

Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5'-terminus is linked to a VPg protein and the 3'-terminus has a poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both genome and viral messenger RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the mature nonstructural proteins. Subgenomic RNA encodes for ORF2 capsid protein and ORF3 minor structural protein. ORF2 encodes a capsid precursor protein that is proteolytically processed by the viral proteinase to yield the mature capsid protein. ORF3 encodes a small structural protein VP2 which is expressed through RNA termination-reinitiation.

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors mediates endocytosis of the virus into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.

Host-virus interaction

Host gene expression shutoff by virus

Feline calicivirus mediates host translation shutoff by cleaving PABP1 .

Matching UniProtKB/Swiss-Prot entries

23 entries grouped by strain (browse by keywords)

All proteins are shown (view only 18 complete proteome entries)

3 entries

Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain

Select_allDeselect_all
CAPSD_FCVUR Capsid protein (Coat protein) (CP) [Cleaved into: Protein 40k]
VP2_FCVUR Protein VP2 (Minor capsid protein)
POLG_FCVUR Genome polyprotein [Cleaved into: Protein p5.6; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein ...

3 entries

Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) reference strain

Select_allDeselect_all
CAPSD_VESVA Capsid protein (CP) (Coat protein) (VP1)
POLG_VESVA Genome polyprotein [Cleaved into: Protein p16; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein p30; ...
VP2_VESVA Protein VP2 (Minor capsid protein)

3 entries

Canine calicivirus (strain 48) (CaCV)

Select_allDeselect_all
CAPSD_CACV4 Capsid protein (Coat protein) (CP) (VP1)
VP2_CACV4 Protein VP2 (Minor capsid protein)
POLG_CACV4 Genome polyprotein [Cleaved into: Protein p18; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein p30; ...

3 entries

Feline calicivirus (strain CFI/68 FIV) (FCV)

Select_allDeselect_all
CAPSD_FCVC6 Capsid protein (Coat protein) (CP) (VP1) [Cleaved into: Protein 40k]
VP2_FCVC6 Protein VP2 (Minor capsid protein)
POLG_FCVC6 Genome polyprotein [Cleaved into: Protein p5.6; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein ...

3 entries

Feline calicivirus (strain F9) (FCV)

Select_allDeselect_all
CAPSD_FCVF9 Capsid protein (Coat protein) (CP) (VP1) [Cleaved into: Protein 40k]
VP2_FCVF9 Protein VP2 (Minor capsid protein)
POLG_FCVF9 Genome polyprotein [Cleaved into: Protein p5.6; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein ...

3 entries

Feline calicivirus (strain Japanese F4) (FCV)

Select_allDeselect_all
CAPSD_FCVF4 Capsid protein (Coat protein) (CP) (VP1) [Cleaved into: Protein 40k]
VP2_FCVF4 Protein VP2 (Minor capsid protein)
POLG_FCVF4 Genome polyprotein [Cleaved into: Protein p5.6; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein ...

3 entries

San Miguel sea lion virus serotype 1 (SMSV-1) (SMSV serotype 1)

Select_allDeselect_all
CAPSD_SMSV1 Capsid protein (Coat protein) (CP) (VP1)
VP2_SMSV1 Protein VP2 (Minor capsid protein)
POLG_SMSV1 Genome polyprotein [Cleaved into: Protein p16; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein p30; ...

2 entries

San Miguel sea lion virus serotype 4 (SMSV-4) (SMSV serotype 4)

Select_allDeselect_all
CAPSD_SMSV4 Capsid protein (Coat protein) (CP) (VP1)
VP2_SMSV4 Protein VP2 (Minor capsid protein)