Vesiculovirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Host gene expression shutoff

Vesicular stomatitis virus matrix protein blocks nuclear pores, resulting in host mRNA nuclear export inhibiton This shutoff of host gene expression prevents effective antiviral response by the infected cell.

Matching UniProtKB/Swiss-Prot entries

57 entries grouped by protein (browse by keywords)

All proteins are shown (view only 45 complete proteome entries)

8 entries

Protein C'

Select_allDeselect_all
C_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
C_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain
C_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
C_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
C_VSIVM
Vesicular stomatitis Indiana virus (strain Mudd-Summers) (VSIV)
C_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
C_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)
C_VSNJM
Vesicular stomatitis New Jersey virus (strain Missouri subtype Hazelhurst) (VSNJV)

11 entries

Glycoprotein

Select_allDeselect_all
GLYCO_CHAV
Chandipura virus (strain I653514) (CHPV) reference strain
GLYCO_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
GLYCO_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain
GLYCO_COCAV
Cocal virus (COCV)
GLYCO_ISFV
Isfahan virus (ISFV)
GLYCO_PIRYV
Piry virus (PIRYV)
GLYCO_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
GLYCO_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
GLYCO_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
GLYCO_VSIVO
Vesicular stomatitis Indiana virus (strain Orsay) (VSIV)
GLYCO_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

9 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_CHAV
Chandipura virus (strain I653514) (CHPV) reference strain
L_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
L_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain
L_ISFV
Isfahan virus (ISFV)
L_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
L_VSIVM
Vesicular stomatitis Indiana virus (strain Mudd-Summers) (VSIV)
L_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
L_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)
L_VSNJH
Vesicular stomatitis New Jersey virus (strain Hazelhurst subtype Hazelhurst) (VSNJV)

9 entries

Matrix protein

Select_allDeselect_all
MATRX_CHAV
Chandipura virus (strain I653514) (CHPV) reference strain
MATRX_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
MATRX_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain
MATRX_ISFV
Isfahan virus (ISFV)
MATRX_PIRYV
Piry virus (PIRYV)
MATRX_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
MATRX_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
MATRX_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
MATRX_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

9 entries

Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Select_allDeselect_all
NCAP_CHAV
Chandipura virus (strain I653514) (CHPV) reference strain
NCAP_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
NCAP_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain
NCAP_ISFV
Isfahan virus (ISFV)
NCAP_PIRYV
Piry virus (PIRYV)
NCAP_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
NCAP_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
NCAP_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
NCAP_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

11 entries

Phosphoprotein (Protein P) (Protein M1)

Select_allDeselect_all
PHOSP_CHAV
Chandipura virus (strain I653514) (CHPV) reference strain
PHOSP_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain

Phosphoprotein (P protein) (Protein M1)

PHOSP_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain

Phosphoprotein (P protein) (Protein M1)

PHOSP_ISFV
Isfahan virus (ISFV)
PHOSP_PIRYV
Piry virus (PIRYV)
PHOSP_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)

Phosphoprotein (Protein P) (NS) (Protein M1)

PHOSP_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
PHOSP_VSIVM
Vesicular stomatitis Indiana virus (strain Mudd-Summers) (VSIV)
PHOSP_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)

Phosphoprotein (Protein P) (NS) (Protein M1)

PHOSP_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

Phosphoprotein (Protein P) (NS) (Protein M1)

PHOSP_VSNJM
Vesicular stomatitis New Jersey virus (strain Missouri subtype Hazelhurst) (VSNJV)