Orthohantavirus

VIRION

Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins. Some hantaviruses also encode a NSs protein on their S segment.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching . Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped by L protein during synthesis. Puumala virus expressed an additional NSs by leaky scanning in the NS gene.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by protein (browse by keywords)

All proteins are shown (view only 11 complete proteome entries)

13 entries

Envelopment polyprotein (M polyprotein)

Select_allDeselect_all
GP_HANTV
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain

Envelopment polyprotein (Glycoprotein precursor) (M polyprotein)

GP_HANTB
Hantaan virus (strain B-1) (Korean hemorrhagic fever virus)
GP_HANTH
Hantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)
GP_HANTL
Hantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)
GP_NYV
New York virus (NYV)
GP_PHV
Prospect Hill virus (PHV)
GP_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984)
GP_PUUMK
Puumala virus (strain K27)
GP_PUUMP
Puumala virus (strain P360)
GP_PUUMS
Puumala virus (strain Sotkamo/V-2969/81)
GP_SEOU8
Seoul virus (strain 80-39)
GP_SEOUR
Seoul virus (strain R22)
GP_SEOUS
Seoul virus (strain SR-11) (Sapporo rat virus)

4 entries

RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_HANTV
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain
L_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984)
L_PUUMS
Puumala virus (strain Sotkamo/V-2969/81)
L_SEOU8
Seoul virus (strain 80-39)

9 entries

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_allDeselect_all
NCAP_HANTV
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain
NCAP_PHV
Prospect Hill virus (PHV)
NCAP_PUUME
Puumala virus (strain Evo/12CG/93)
NCAP_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984)
NCAP_PUUMK
Puumala virus (strain K27)
NCAP_PUUMP
Puumala virus (strain P360)
NCAP_PUUMS
Puumala virus (strain Sotkamo/V-2969/81)
NCAP_PUUMU
Puumala virus (strain Udmurtia/894CG/91)
NCAP_SEOUS
Seoul virus (strain SR-11) (Sapporo rat virus)

2 entries

Non-structural protein NS-S (NSs)

Select_allDeselect_all
NSS_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984)
NSS_PUUMS
Puumala virus (strain Sotkamo/V-2969/81)