Lyssavirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins, plus 4 by alternative initiation.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host Interferon induction

Rabies nucleoprotein plays a role in inhibition of RIG-I antiviral signaling
Rabies phosphoprotein may inhibit IRF-3 phosphorylation

Inhibition of host type I interferon signaling

Rabies phosphoprotein may inhibit STAT-I antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.

Inhibition of T-cell response

Rabies nucleoprotein may act as a superantigen by inhibiting Vbeta T-Cell repertoire

.

Matching UniProtKB/Swiss-Prot entries

108 entries grouped by protein (browse by keywords)

All proteins are shown (view only 91 complete proteome entries)

1 entry

Putative uncharacterized protein C

C_RABVA
Rabies virus (strain PM1503/AVO1) (RABV)

24 entries

Glycoprotein

Select_allDeselect_all
GLYCO_ABLVB
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
GLYCO_EBLV1
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain
GLYCO_EBLV2
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain
GLYCO_MOKV
Mokola virus (MOKV) reference strain
GLYCO_RABVP
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
GLYCO_ABLVH
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
GLYCO_ARAV
Aravan virus (ARAV)
GLYCO_DUVV
Duvenhage virus (DUVV)
GLYCO_IRKV
Irkut virus (IRKV)
GLYCO_KHUV
Khujand virus (KHUV)
GLYCO_LBV
Lagos bat virus (LBV)
GLYCO_RABVA
Rabies virus (strain PM1503/AVO1) (RABV)
GLYCO_RABVB
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
GLYCO_RABVC
Rabies virus (strain CVS-11) (RABV)
GLYCO_RABVD
Rabies virus (strain China/DRV) (RABV)
GLYCO_RABVE
Rabies virus (strain ERA) (RABV)
GLYCO_RABVH
Rabies virus (strain HEP-Flury) (RABV)
GLYCO_RABVI
Rabies virus (strain India) (RABV)
GLYCO_RABVN
Rabies virus (strain Nishigahara RCEH) (RABV)
GLYCO_RABVR
Rabies virus (strain China/MRV) (RABV)
GLYCO_RABVS
Rabies virus (strain SAD B19) (RABV)
GLYCO_RABVT
Rabies virus (isolate Human/Algeria/1991) (RABV)
GLYCO_RABVV
Rabies virus (strain Vnukovo-32) (RABV)
GLYCO_WCBV
West Caucasian bat virus (WCBV)

15 entries

Large structural protein (Protein L) (Replicase) (Transcriptase)

Select_allDeselect_all
L_ABLVB
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
L_EBLV1
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

L_EBLV2
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

L_MOKV
Mokola virus (MOKV) reference strain
L_RABVP
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
L_ABLVH
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
L_RABVA
Rabies virus (strain PM1503/AVO1) (RABV)
L_RABVB
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
L_RABVD
Rabies virus (strain China/DRV) (RABV)
L_RABVE
Rabies virus (strain ERA) (RABV)
L_RABVH
Rabies virus (strain HEP-Flury) (RABV)
L_RABVI
Rabies virus (strain India) (RABV)
L_RABVN
Rabies virus (strain Nishigahara RCEH) (RABV)
L_RABVR
Rabies virus (strain China/MRV) (RABV)
L_RABVS
Rabies virus (strain SAD B19) (RABV)

21 entries

Matrix protein (Phosphoprotein M2)

Select_allDeselect_all
MATRX_ABLVB
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
MATRX_EBLV1
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

Matrix protein

MATRX_EBLV2
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

Matrix protein

MATRX_MOKV
Mokola virus (MOKV) reference strain
MATRX_RABVP
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
MATRX_ABLVH
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
MATRX_ARAV
Aravan virus (ARAV)
MATRX_IRKV
Irkut virus (IRKV)
MATRX_KHUV
Khujand virus (KHUV)
MATRX_LBV
Lagos bat virus (LBV)

Matrix protein

MATRX_RABVA
Rabies virus (strain PM1503/AVO1) (RABV)
MATRX_RABVB
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
MATRX_RABVC
Rabies virus (strain CVS-11) (RABV)
MATRX_RABVD
Rabies virus (strain China/DRV) (RABV)
MATRX_RABVE
Rabies virus (strain ERA) (RABV)
MATRX_RABVH
Rabies virus (strain HEP-Flury) (RABV)
MATRX_RABVI
Rabies virus (strain India) (RABV)
MATRX_RABVN
Rabies virus (strain Nishigahara RCEH) (RABV)
MATRX_RABVR
Rabies virus (strain China/MRV) (RABV)
MATRX_RABVS
Rabies virus (strain SAD B19) (RABV)
MATRX_WCBV
West Caucasian bat virus (WCBV)

24 entries

Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Select_allDeselect_all
NCAP_ABLVB
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
NCAP_EBLV1
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain
NCAP_EBLV2
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain
NCAP_MOKV
Mokola virus (MOKV) reference strain
NCAP_RABVP
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
NCAP_ABLVH
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
NCAP_ARAV
Aravan virus (ARAV)
NCAP_DUVV
Duvenhage virus (DUVV)
NCAP_IRKV
Irkut virus (IRKV)
NCAP_KHUV
Khujand virus (KHUV)
NCAP_LBV
Lagos bat virus (LBV)
NCAP_RABVA
Rabies virus (strain PM1503/AVO1) (RABV)
NCAP_RABVB
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
NCAP_RABVC
Rabies virus (strain CVS-11) (RABV)
NCAP_RABVD
Rabies virus (strain China/DRV) (RABV)
NCAP_RABVE
Rabies virus (strain ERA) (RABV)
NCAP_RABVF
Rabies virus (isolate Fox/Ontario/1991) (RABV)
NCAP_RABVH
Rabies virus (strain HEP-Flury) (RABV)
NCAP_RABVI
Rabies virus (strain India) (RABV)
NCAP_RABVN
Rabies virus (strain Nishigahara RCEH) (RABV)
NCAP_RABVR
Rabies virus (strain China/MRV) (RABV)
NCAP_RABVS
Rabies virus (strain SAD B19) (RABV)
NCAP_RABVU
Rabies virus (isolate Skunk/Ontario/1991) (RABV)
NCAP_WCBV
West Caucasian bat virus (WCBV)

23 entries

Phosphoprotein (Protein P) (Protein M1)

Select_allDeselect_all
PHOSP_ABLVB
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
PHOSP_EBLV1
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain
PHOSP_EBLV2
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain
PHOSP_MOKV
Mokola virus (MOKV) reference strain
PHOSP_RABVP
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
PHOSP_ABLVH
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
PHOSP_ARAV
Aravan virus (ARAV)
PHOSP_DUVV
Duvenhage virus (DUVV)
PHOSP_IRKV
Irkut virus (IRKV)
PHOSP_KHUV
Khujand virus (KHUV)
PHOSP_LBV
Lagos bat virus (LBV)
PHOSP_RABVA
Rabies virus (strain PM1503/AVO1) (RABV)
PHOSP_RABVB
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
PHOSP_RABVC
Rabies virus (strain CVS-11) (RABV)
PHOSP_RABVD
Rabies virus (strain China/DRV) (RABV)
PHOSP_RABVE
Rabies virus (strain ERA) (RABV)
PHOSP_RABVH
Rabies virus (strain HEP-Flury) (RABV)
PHOSP_RABVI
Rabies virus (strain India) (RABV)
PHOSP_RABVM
Rabies virus (strain PM) (RABV)
PHOSP_RABVN
Rabies virus (strain Nishigahara RCEH) (RABV)
PHOSP_RABVR
Rabies virus (strain China/MRV) (RABV)
PHOSP_RABVS
Rabies virus (strain SAD B19) (RABV)
PHOSP_WCBV
West Caucasian bat virus (WCBV)