HIV-1 VIF protein

P17 p7 protease membrane multimerization
FUNCTION
    Counteracts the innate antiviral activity of host cytidine deaminase nucleic acid editing enzymes APOBEC3D (A3D), APOBEC3G (A3G), APOBEC3F (A3F) and APOBEC3H (A3H) by degrading these lethally hypermutating enzymes and preventing their incorporation into progeny virions .
INTERACTIONS
    Recruits an active ubiquitin ligase complex composed of Vif, elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3 proteins and direct them to the 26S proteasome for degradation
SUBCELLULAR LOCATION
  • Virion
  • Host cytoplasm
  • Host cell membrane
TIMING OF EXPRESSION
    Late