Marburgvirus

Filamentous, greatly variable up to 1400 nm in length. Diameter is about 80nm.

GENOME

Negative-stranded RNA linear genome, about 19 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment to host receptors through GP glycoprotein mediates is endocytosed into vesicles in the host cell by apoptotic mimicry.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane, buds via the host ESCRT complexes from the plasma membrane, releasing the virion.

Host-virus interaction

Inhibition of host interferon signaling

Vp40 protein prevents interferon signaling by preventing the tyrosine phosphorylation of JAK1 and subsequent phosphorylation of STAT1 and STAT2. .

Matching UniProtKB/Swiss-Prot entries

35 entries grouped by protein (browse by keywords)

5 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
L_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
L_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
L_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
L_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

5 entries

Nucleoprotein (Nucleocapsid protein)

Select_allDeselect_all
NCAP_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain

Nucleoprotein (Nucleocapsid protein) (Protein N)

NCAP_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
NCAP_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
NCAP_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))

Nucleoprotein (Nucleocapsid protein) (Protein N)

NCAP_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

5 entries

Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)

Select_allDeselect_all
VGP_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
VGP_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
VGP_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
VGP_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
VGP_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

5 entries

Membrane-associated protein VP24

Select_allDeselect_all
VP24_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
VP24_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
VP24_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
VP24_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
VP24_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

5 entries

Minor nucleoprotein VP30 (Transcription activator VP30)

Select_allDeselect_all
VP30_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
VP30_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
VP30_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
VP30_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
VP30_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

5 entries

Polymerase cofactor VP35

Select_allDeselect_all
VP35_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
VP35_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
VP35_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
VP35_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
VP35_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

5 entries

Matrix protein VP40 (Membrane-associated protein VP40)

Select_allDeselect_all
VP40_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
VP40_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
VP40_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
VP40_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
VP40_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))