Lyssavirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins, plus 4 by alternative initiation.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host Interferon induction

Rabies nucleoprotein plays a role in inhibition of RIG-I antiviral signaling
Rabies phosphoprotein may inhibit IRF-3 phosphorylation

Inhibition of host type I interferon signaling

Rabies phosphoprotein may inhibit STAT-I antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.

Inhibition of T-cell response

Rabies nucleoprotein may act as a superantigen by inhibiting Vbeta T-Cell repertoire

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Matching UniProtKB/Swiss-Prot entries

108 entries grouped by strain (browse by keywords)

All proteins are shown (view only 91 complete proteome entries)

5 entries

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

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GLYCO_ABLVB Glycoprotein
NCAP_ABLVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_ABLVB Matrix protein (Phosphoprotein M2)
L_ABLVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_ABLVB Phosphoprotein (Protein P) (Protein M1)

5 entries

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

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GLYCO_EBLV1 Glycoprotein
NCAP_EBLV1 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_EBLV1 Matrix protein
L_EBLV1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_EBLV1 Phosphoprotein (Protein P) (Protein M1)

5 entries

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

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GLYCO_EBLV2 Glycoprotein
NCAP_EBLV2 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_EBLV2 Matrix protein
L_EBLV2 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_EBLV2 Phosphoprotein (Protein P) (Protein M1)

5 entries

Mokola virus (MOKV) reference strain

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GLYCO_MOKV Glycoprotein
NCAP_MOKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_MOKV Matrix protein (Phosphoprotein M2)
L_MOKV Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_MOKV Phosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

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GLYCO_RABVP Glycoprotein
NCAP_RABVP Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_RABVP Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVP Matrix protein (Phosphoprotein M2)
PHOSP_RABVP Phosphoprotein (Protein P) (Protein M1)

4 entries

Rabies virus (strain SAD B19) (RABV) reference strain

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GLYCO_RABVS Glycoprotein
NCAP_RABVS Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_RABVS Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVS Matrix protein (Phosphoprotein M2)

6 entries

Rabies virus (strain PM1503/AVO1) (RABV)

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C_RABVA Putative uncharacterized protein C
GLYCO_RABVA Glycoprotein
NCAP_RABVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVA Matrix protein (Phosphoprotein M2)
L_RABVA Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVA Phosphoprotein (Protein P) (Protein M1)

5 entries

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

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GLYCO_ABLVH Glycoprotein
NCAP_ABLVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_ABLVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_ABLVH Matrix protein (Phosphoprotein M2)
PHOSP_ABLVH Phosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain China/DRV) (RABV)

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GLYCO_RABVD Glycoprotein
NCAP_RABVD Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVD Matrix protein (Phosphoprotein M2)
L_RABVD Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVD Phosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain China/MRV) (RABV)

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GLYCO_RABVR Glycoprotein
NCAP_RABVR Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVR Matrix protein (Phosphoprotein M2)
L_RABVR Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVR Phosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain ERA) (RABV)

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GLYCO_RABVE Glycoprotein
NCAP_RABVE Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_RABVE Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVE Matrix protein (Phosphoprotein M2)
PHOSP_RABVE Phosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain HEP-Flury) (RABV)

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GLYCO_RABVH Glycoprotein
NCAP_RABVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVH Matrix protein (Phosphoprotein M2)
L_RABVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVH Phosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain India) (RABV)

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GLYCO_RABVI Glycoprotein
NCAP_RABVI Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_RABVI Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVI Matrix protein (Phosphoprotein M2)
PHOSP_RABVI Phosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain Nishigahara RCEH) (RABV)

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GLYCO_RABVN Glycoprotein
NCAP_RABVN Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_RABVN Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVN Matrix protein (Phosphoprotein M2)
PHOSP_RABVN Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain SAD B19) (RABV)

PHOSP_RABVS Phosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

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GLYCO_RABVB Glycoprotein
NCAP_RABVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_RABVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVB Matrix protein (Phosphoprotein M2)
PHOSP_RABVB Phosphoprotein (Protein P) (Protein M1)

4 entries

Aravan virus (ARAV)

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GLYCO_ARAV Glycoprotein
NCAP_ARAV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_ARAV Matrix protein (Phosphoprotein M2)
PHOSP_ARAV Phosphoprotein (Protein P) (Protein M1)

4 entries

Irkut virus (IRKV)

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GLYCO_IRKV Glycoprotein
NCAP_IRKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_IRKV Matrix protein (Phosphoprotein M2)
PHOSP_IRKV Phosphoprotein (Protein P) (Protein M1)

4 entries

Khujand virus (KHUV)

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GLYCO_KHUV Glycoprotein
NCAP_KHUV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_KHUV Matrix protein (Phosphoprotein M2)
PHOSP_KHUV Phosphoprotein (Protein P) (Protein M1)

4 entries

Lagos bat virus (LBV)

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GLYCO_LBV Glycoprotein
NCAP_LBV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_LBV Matrix protein
PHOSP_LBV Phosphoprotein (Protein P) (Protein M1)

4 entries

Rabies virus (strain CVS-11) (RABV)

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GLYCO_RABVC Glycoprotein
NCAP_RABVC Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVC Matrix protein (Phosphoprotein M2)
PHOSP_RABVC Phosphoprotein (Protein P) (Protein M1)

4 entries

West Caucasian bat virus (WCBV)

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GLYCO_WCBV Glycoprotein
NCAP_WCBV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_WCBV Matrix protein (Phosphoprotein M2)
PHOSP_WCBV Phosphoprotein (Protein P) (Protein M1)

3 entries

Duvenhage virus (DUVV)

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GLYCO_DUVV Glycoprotein
NCAP_DUVV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_DUVV Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (isolate Fox/Ontario/1991) (RABV)

NCAP_RABVF Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Rabies virus (isolate Human/Algeria/1991) (RABV)

GLYCO_RABVT Glycoprotein

1 entry

Rabies virus (isolate Skunk/Ontario/1991) (RABV)

NCAP_RABVU Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Rabies virus (strain PM) (RABV)

PHOSP_RABVM Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain Vnukovo-32) (RABV)

GLYCO_RABVV Glycoprotein