Filoviridae

Filamentous 790 nm long for Marburg virus and 970 nm long for Ebolavirus. Diameter is about 80nm.

GENOME

Negative-stranded RNA linear genome, about 18-19 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.
In Ebolavirus, the primary product of the unedited transcript of GP gene yields a smaller non-structural glycoprotein sGP which is efficiently secreted from infected cells. RNA editing allows expression of full-length GP.

REPLICATION

CYTOPLASMIC

  1. Attachment to host receptors through GP glycoprotein mediates is endocytosed into vesicles in the host cell by apoptotic mimicry
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane, buds via the host ESCRT complexes from the plasma membrane, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

Vp35 protein prevents host interferon induction by inhibiting host TBK1-IKBKE-DDX3 complex

Inhibition of host interferon signaling

Vp24 protein block interferon signaling by preventing STAT1 signaling. May act by binding host karyopherin ? proteins, thereby preventing them from transporting the tyrosine-phosphorylated transcription factor STAT1 to the nucleus. May directly bind to STAT1 to prevent its signaling .

Antigenic subvertion

Small Glycoprotein (sGP) is a secreted truncated version of GP that prevent host antibodies anti-GP to effectively neutralize it .

Matching UniProtKB/Swiss-Prot entries

97 entries grouped by protein (browse by keywords)

All proteins are shown (view only 80 complete proteome entries)

11 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain
L_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
L_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
L_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
L_EBOSM
Sudan ebolavirus (strain Maleo-79) (SEBOV) (Sudan Ebola virus)
L_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
L_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
L_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
L_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
L_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
L_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

12 entries

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_allDeselect_all
NCAP_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain
NCAP_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
NCAP_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
NCAP_EBOG4
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
NCAP_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
NCAP_EBOSB
Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
NCAP_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
NCAP_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
NCAP_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)

Nucleoprotein (Nucleocapsid protein)

NCAP_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))

Nucleoprotein (Nucleocapsid protein)

NCAP_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
NCAP_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

Nucleoprotein (Nucleocapsid protein)

16 entries

Envelope glycoprotein (GP1,2) (GP)

Select_allDeselect_all
VGP_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain
VGP_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VGP_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain

Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)

VGP_EBOEC
Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus)
VGP_EBOG4
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
VGP_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VGP_EBORS
Reston ebolavirus (strain Siena/Philippine-92) (REBOV) (Reston Ebola virus)
VGP_EBOSB
Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
VGP_EBOSM
Sudan ebolavirus (strain Maleo-79) (SEBOV) (Sudan Ebola virus)
VGP_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
VGP_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
VGP_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)

Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)

VGP_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))

Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)

VGP_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))

Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)

VGP_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)

VGP_TAFVC
Tai Forest ebolavirus (strain Cote d'Ivoire-94) (TAFV) (Cote d'Ivoire Ebola virus)

11 entries

Membrane-associated protein VP24

Select_allDeselect_all
VP24_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain
VP24_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VP24_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
VP24_EBOG4
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
VP24_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VP24_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
VP24_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
VP24_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
VP24_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
VP24_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
VP24_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

10 entries

Minor nucleoprotein VP30 (Transcription activator VP30)

Select_allDeselect_all
VP30_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain
VP30_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VP30_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
VP30_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VP30_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
VP30_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
VP30_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
VP30_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
VP30_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
VP30_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

10 entries

Polymerase cofactor VP35

Select_allDeselect_all
VP35_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain
VP35_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VP35_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
VP35_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VP35_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
VP35_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
VP35_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
VP35_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
VP35_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
VP35_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

11 entries

Matrix protein VP40 (Membrane-associated protein VP40)

Select_allDeselect_all
VP40_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain
VP40_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VP40_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
VP40_EBOG4
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
VP40_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VP40_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
VP40_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
VP40_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
VP40_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
VP40_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
VP40_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

11 entries

Pre-small/secreted glycoprotein (pre-sGP)

Select_allDeselect_all
VSGP_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain
VSGP_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VSGP_EBOEC
Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus)
VSGP_EBOG4
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
VSGP_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VSGP_EBORS
Reston ebolavirus (strain Siena/Philippine-92) (REBOV) (Reston Ebola virus)
VSGP_EBOSB
Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
VSGP_EBOSM
Sudan ebolavirus (strain Maleo-79) (SEBOV) (Sudan Ebola virus)
VSGP_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
VSGP_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
VSGP_TAFVC
Tai Forest ebolavirus (strain Cote d'Ivoire-94) (TAFV) (Cote d'Ivoire Ebola virus)

5 entries

Super small secreted glycoprotein (SsGP)

Select_allDeselect_all
VSSGP_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain
VSSGP_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VSSGP_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VSSGP_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
VSSGP_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)