Human adenovirus type C virion

Virion structure

Protein name Copies per virion * Localization Function
capsid shell Hexon protein 720 Major capsid protein that assembles as 240 homotrimers Pseudo T=25 icosahedral capsid , Microtubular inwards viral transport
Penton protein 60 Major capsid protein that forms the penton complexes at each virion vertex Pseudo T=25 icosahedral capsid , Viral attachment to host host entry receptor, Clathrin-mediated endocytosis of virus by host
Fiber protein 36 Major capsid protein that forms the fiber spikes at the surface of the capsidViral attachment to host adhesion receptor
Capsid vertex protein IIIa 60 Cement protein that surrounds the border of each facet on the exterior Hexon stabilization
genome packaging
Pre-protein VI, Endosome lysis protein, Protease cofactor 360 Cement protein that binds the peripentonal hexons and links the viral genome to the capsid (with VIII and V) Pre-protein VI: Scaffolding of icosahedron/Nuclear capsid assembly?
Endosome lysis protein: Viral penetration via permeabilization of host endosomal membrane, peripentonal hexons stabilization
Protease cofactor: Virion maturation
Hexon-linking protein VIII 120 Cement protein that binds the peripentonal hexons and links the viral genome to the capsid (with V and VI) Peripentonal hexons stabilization
Hexon-interlacing protein IX 240 Cement protein that binds the hexons on the capsid exterior Hexons stabilization
Viral penetration into host nucleus
Packaging protein 1 / IVa2 6-8 Localizes at a unique vertex Genome packaging
Core Protease 20 Virion interior Virion maturation
Core-capsid bridging protein V 157 DNA-binding protein thatlinks the viral genome to the capsid (with VIII and VI) Forms a ternary complex with proteins VI and V that interacts with the peripentonal hexons and links the viral genome Nuclear capsid assembly?
Histone-like nucleoprotein VII 814-852 DNA-binding protein Histone-like nucleoprotein, DNA binding/condensation
Core protein X 125-160 DNA-binding protein Nucleoprotein, DNA binding/condensation
Terminal protein 2 Located at each DNA end DNA synthesis priming, Strand displacement replication
  • Ref. Bergstroem et al. 2012 Perez-Vargas et al. 2014