Orthobunyavirus

VIRION

Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is about 6.9kb, M segment about 4.5kb and S segment about 1kb.
Encodes for six proteins.

GENE EXPRESSION

Transcription starts by viral RNA dependent RNA polymerase (L) binding to a promoter on each encapsidated segment, and is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped by L protein during synthesis using cap snatching ., but are not polyadenylated.

S segment encodes for NSs protein by leaky scanning. M segment encodes for a polyprotein which is cleaved by host protease into Gn, NSm and Gc proteins.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Host-virus interaction

Inhibition of host transcription initiation

The Bunyamwera virus (BUNV) NSs protein plays a role in the inhibition of host RNA polymerase II

Matching UniProtKB/Swiss-Prot entries

26 entries grouped by protein (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

6 entries

Envelopment polyprotein (M polyprotein)

Select_allDeselect_all
GP_BUNL8
Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
GP_BUNYW
Bunyamwera virus (BUNV) reference strain
GP_BUNGE
Bunyavirus germiston
GP_BUNL7
Bunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974)
GP_BUNSH
Bunyavirus snowshoe hare
GP_SBVBH
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

3 entries

RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_BUNL8
Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
L_BUNYW
Bunyamwera virus (BUNV) reference strain
L_SBVBH
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

8 entries

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_allDeselect_all
NCAP_BUNL8
Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
NCAP_BUNYW
Bunyamwera virus (BUNV) reference strain
NCAP_AINOV
Aino virus
NCAP_BUNGE
Bunyavirus germiston
NCAP_BUNLC
Bunyavirus La Crosse
NCAP_BUNSH
Bunyavirus snowshoe hare
NCAP_MAGV
Maguari virus
NCAP_SBVBH
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

8 entries

Non-structural protein NS-S

Select_allDeselect_all
NSS_BUNL8
Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
NSS_BUNYW
Bunyamwera virus (BUNV) reference strain
NSS_AINOV
Aino virus
NSS_BUNGE
Bunyavirus germiston
NSS_BUNLC
Bunyavirus La Crosse
NSS_BUNSH
Bunyavirus snowshoe hare
NSS_MAGV
Maguari virus
NSS_SBVBH
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

1 entry

Putative uncharacterized 9.3 kDa protein

Y9KD_MAGV
Maguari virus