Inhibition of host STAT2 by virus

The signal transducer and activator of transcription STAT2(M97934:9606) protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT2(M97934:9606) in IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. IFN-α/β stimulates heterodimerization of STAT1(M97935:9606) and STAT2(M97934:9606), leading to STAT2(M97934:9606) activation and nuclear localization.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 e1a P NS1 NS5 V C

Many viruses modulate the interferon mediated response by acting on STAT2(M97934:9606). This regulation occurs in many different ways. NS5 protein from Dengue virus mediates STAT2(M97934:9606) binding and degradation. Respiratory syncytial virus NS1(O42083) protein degrades STAT2(M97934:9606) by using the elongin-cullin E3 Ligase. Nipah virus V(Q997F2) protein instead prevents STAT2(M97934:9606) activation through direct binding but without targeting it to degradation.

Matching UniProtKB/Swiss-Prot entries

85 entries grouped by protein (browse by keywords)

All proteins are shown (view only 62 complete proteome entries)

13 entries

Protein C

Select_allDeselect_all
C_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
C_SENDO
Sendai virus (strain Ohita) (SeV) reference strain

Protein C'

C_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

Protein C'

C_PI1HB
Human parainfluenza 1 virus (strain C35) (HPIV-1)
C_PI1HC
Human parainfluenza 1 virus (strain C39) (HPIV-1)
C_PI1HD
Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)
C_PI1HE
Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)
C_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

Protein C (VP18 protein)

C_SEND6
Sendai virus (strain 6/94) (SeV)

Protein C'

C_SENDA
Sendai virus (strain Hamamatsu) (SeV)

Protein C'

C_SENDF
Sendai virus (strain Fushimi) (SeV)

Protein C'

C_SENDH
Sendai virus (strain Harris) (SeV)

Protein C'

C_SENDN
Sendai virus (strain Nagoya) (SeV)

Protein C'

4 entries

Non-structural protein 1 (Non-structural protein 1C)

Select_allDeselect_all
NS1_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
NS1_HRSV1
Human respiratory syncytial virus B (strain 18537)
NS1_HRSVL
Human respiratory syncytial virus A (strain Long)
NS1_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

23 entries

Phosphoprotein (Protein P) (Protein M1)

Select_allDeselect_all
PHOSP_ABLVB
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
PHOSP_EBLV1
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain
PHOSP_EBLV2
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain
PHOSP_MOKV
Mokola virus (MOKV) reference strain
PHOSP_RABVP
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
PHOSP_ABLVH
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
PHOSP_ARAV
Aravan virus (ARAV)
PHOSP_DUVV
Duvenhage virus (DUVV)
PHOSP_IRKV
Irkut virus (IRKV)
PHOSP_KHUV
Khujand virus (KHUV)
PHOSP_LBV
Lagos bat virus (LBV)
PHOSP_RABVA
Rabies virus (strain PM1503/AVO1) (RABV)
PHOSP_RABVB
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
PHOSP_RABVC
Rabies virus (strain CVS-11) (RABV)
PHOSP_RABVD
Rabies virus (strain China/DRV) (RABV)
PHOSP_RABVE
Rabies virus (strain ERA) (RABV)
PHOSP_RABVH
Rabies virus (strain HEP-Flury) (RABV)
PHOSP_RABVI
Rabies virus (strain India) (RABV)
PHOSP_RABVM
Rabies virus (strain PM) (RABV)
PHOSP_RABVN
Rabies virus (strain Nishigahara RCEH) (RABV)
PHOSP_RABVR
Rabies virus (strain China/MRV) (RABV)
PHOSP_RABVS
Rabies virus (strain SAD B19) (RABV)
PHOSP_WCBV
West Caucasian bat virus (WCBV)

30 entries

Genome polyprotein

Select_allDeselect_all
POLG_DEN1W
Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain
POLG_YEFV1
Yellow fever virus (strain 17D vaccine) (YFV) reference strain
POLG_ZIKV
Zika virus (strain Mr 766) (ZIKV) reference strain
POLG_DEN1B
Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)
POLG_DEN1S
Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)
POLG_DEN26
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)
POLG_DEN27
Dengue virus type 2 (strain 16681-PDK53) (DENV-2)
POLG_DEN28
Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)
POLG_DEN2J
Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)
POLG_DEN2N
Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)
POLG_DEN2P
Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)
POLG_DEN2Q
Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)
POLG_DEN3C
Dengue virus type 3 (strain China/80-2/1980) (DENV-3)
POLG_DEN3I
Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)
POLG_DEN3M
Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)
POLG_DEN3P
Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)
POLG_DEN3S
Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)
POLG_DEN4D
Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)
POLG_DEN4H
Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)
POLG_DEN4P
Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)
POLG_DEN4S
Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)
POLG_DEN4T
Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)
POLG_YEFVA
Yellow fever virus (strain Ghana/Asibi/1927) (YFV)
POLG_YEFVC
Yellow fever virus (isolate Ivory Coast/1999) (YFV)
POLG_YEFVE
Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)
POLG_YEFVF
Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)
POLG_YEFVI
Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)
POLG_YEFVN
Yellow fever virus (isolate Angola/14FA/1971) (YFV)
POLG_YEFVT
Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)
POLG_YEFVU
Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)

15 entries

Non-structural protein V

Select_allDeselect_all
V_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
V_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
V_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Non-structural protein V (Non-structural protein NS1)

V_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
V_MUMP1
Mumps virus (strain SBL-1) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPE
Mumps virus (strain Enders) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPS
Mumps virus (strain SBL) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_NIPAV
Nipah virus
V_PHODV
Phocine distemper virus (PDV)
V_PI2H
Human parainfluenza 2 virus (HPIV-2)
V_RINDK
Rinderpest virus (strain Kabete O) (RDV)