Mandarivirus

VIRION

Non-enveloped, flexuous, filamentous, 650 nm or more long and 13 nm in diameter.

GENOME

Linear ssRNA(+) genome of 7.5 kb in size. The 3' terminus is polyadenylated. Encodes for 6 proteins.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA-dependent RNA polymerase (RdRp) is translated directly from the genomic RNA. The other ORFS are transcribed presumably as subgenomic mRNAs (sgRNAs).

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated as a monocistronic mRNA to produce the RdRp (encoded by the 5'-proximal ORF).
  4. Replication occurs in viral factories recruited by TGB1. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Internal subgenomic promoters are used to transcribe the sgRNAs. Traduction of these sgRNAs yields the capsid and movement proteins.
  7. Assembly of new virus particles.
  8. Triple gene block proteins (TGBp) allow cell-to-cell and long-distance movement.

Matching UniProtKB/Swiss-Prot entries

6 entries grouped by protein (browse by keywords)

1 entry

Capsid protein (CP) (Coat protein)

CAPSD_ICRSV
Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV) reference strain

1 entry

RNA replication protein

RDRP_ICRSV
Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV) reference strain

1 entry

Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block 1 protein) (TGBp1)

TGB1_ICRSV
Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV) reference strain

1 entry

Movement protein TGB2 (Triple gene block 2 protein) (TGBp2)

TGB2_ICRSV
Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV) reference strain

1 entry

Movement protein TGBp3 (Triple gene block 3 protein) (TGBp3)

TGB3_ICRSV
Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV) reference strain

1 entry

23kDa protein (Putative 23 kDa nucleic acid binding protein)

VNBP_ICRSV
Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV) reference strain