Allolevivirus

VIRION

Non-enveloped, spherical virion about 26 nm in diameter with T=3 icosahedral symmetry composed of 178 CP proteins 889 dimers) and a single A2 maturation protein .

GENOME

Monopartite, linear, ssRNA(+) genome about 4 kb in size. The 5' end is capped. Encodes 4 proteins.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Encodes for 4 ORFs. Cp protein repress replicase translation by binding a RNA hairpin at the start site of this gene. Lysis protein is expressed by suppression of termination of an UGA nonsense codon in levivirus genus (readthrough).

REPLICATION

  1. Adsorption to F pili of target cells induces cleavage and release of the maturation protein.
  2. Genomic RNA enters the bacterium.
  3. Viral proteins are translated.
  4. Viral replicase assembles with host proteins (ribosomal protein S1, translation elongation factors EF-Tu and EF-Ts) to form the active RNA polymerase.
  5. Replication of genomic RNA into a minus strand, which serves as template to produce new positive strand genomes.
  6. Late in infection CP protein bind to a RNA hairpin on the genome, and new virus particles are assembled in the cytoplasm.
  7. Release by cell lysis.

Matching UniProtKB/Swiss-Prot entries

12 entries grouped by protein (browse by keywords)

3 entries

Minor capsid protein A1

Select_allDeselect_all
A1_BPMX1
Enterobacteria phage MX1 (Bacteriophage MX1) reference strain
A1_BPQBE
Escherichia phage Qbeta (Bacteriophage Q-beta) reference strain

Minor capsid protein A1 (A1 read-through protein)

A1_BPSP
Enterobacteria phage SP (Bacteriophage SP) reference strain

3 entries

Capsid protein (CP) (Coat protein)

Select_allDeselect_all
CAPSD_BPMX1
Enterobacteria phage MX1 (Bacteriophage MX1) reference strain
CAPSD_BPQBE
Escherichia phage Qbeta (Bacteriophage Q-beta) reference strain
CAPSD_BPSP
Enterobacteria phage SP (Bacteriophage SP) reference strain

3 entries

Maturation protein A2 (MP) (A2) (Assembly protein) (A protein)

Select_allDeselect_all
MATA2_BPMX1
Enterobacteria phage MX1 (Bacteriophage MX1) reference strain
MATA2_BPQBE
Escherichia phage Qbeta (Bacteriophage Q-beta) reference strain

Maturation protein A2 (MP) (A2 protein)

MATA2_BPSP
Enterobacteria phage SP (Bacteriophage SP) reference strain

3 entries

RNA-directed RNA polymerase subunit beta (EC 2.7.7.48) (RNA replicase beta chain)

Select_allDeselect_all
RDRP_BPMX1
Enterobacteria phage MX1 (Bacteriophage MX1) reference strain
RDRP_BPQBE
Escherichia phage Qbeta (Bacteriophage Q-beta) reference strain

RNA-directed RNA polymerase subunit beta (EC 2.7.7.48) (RNA replicase beta chain) (RNA-directed RNA polymerase subunit II)

RDRP_BPSP
Enterobacteria phage SP (Bacteriophage SP) reference strain