Nepovirus

VIRION

Non-enveloped, 28-30 nm in diameter, T=pseudo3 icosahedral capsid. The large capsid protein (CP) contains the 3 jelly rolls domains characteristic of the picornavirales . Genomic RNAs are encapsidated separately into two different types of particle similar in size.

GENOME

Segmented, bipartite linear ssRNA(+) genome composed of RNA-1=7.5 kb and RNA-2=3.9 kb. Each genomic segment has a VPg linked to its 5' end and a 3' poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and mRNA.
RNA-1 and RNA-2 are translated into two polyproteins, which are then processed into functional proteins. RNA-1 encodes proteins necessary for replication, while RNA-2 encodes for capsid protein and product(s) involved in cell-to-cell movement.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein RNA-1.
  4. Replication occurs in viral factories made of membrane vesicles derived from the ER. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Assembly of new virus particles.
  7. Movement protein allows cell-to-cell movement.

Matching UniProtKB/Swiss-Prot entries

31 entries grouped by strain (browse by keywords)

All proteins are shown (view only 20 complete proteome entries)

4 entries

Tomato ringspot virus (isolate raspberry) (ToRSV) reference strain

Select_allDeselect_all
POL1_TORVR RNA1 polyprotein (P1) [Cleaved into: Protein X1; Protein X2; Putative ATP-dependent helicase (EC ...
POL2_TORVR RNA2 polyprotein (P2) [Cleaved into: Protein X3; Protein X4; Movement protein (MP); Coat protein ...
YR21_TORVR Uncharacterized protein in RNA2
YR22_TORVR Uncharacterized protein in RNA2

3 entries

Beet ringspot virus (BRSV) (Tomato black ring virus (strain S))

Select_allDeselect_all
POL2_BRSV RNA2 polyprotein (P2) [Cleaved into: Protein 2A (P2A); Movement protein (2B-MP); Coat protein ...
POL1_BRSV RNA1 polyprotein (P1) [Cleaved into: P1A protein (1A) (Protease cofactor); Putative ATP-dependent ...
VS48_BRSV Satellite RNA 48 kDa protein

3 entries

Grapevine fanleaf virus (GFLV)

Select_allDeselect_all
POL1_GFLV RNA1 polyprotein (P1) [Cleaved into: P1A protein (1A) (Protease cofactor); Putative ATP-dependent ...
POL2_GFLV RNA2 polyprotein (P2) [Cleaved into: Protein 2A (P2A); Movement protein (2B-MP); Coat protein ...
VP3_GFLV Protein P3

2 entries

Arabis mosaic virus (isolate NW) (ArMV)

Select_allDeselect_all
POL2_ARMVN RNA2 polyprotein (P2) [Cleaved into: Protein 2A (P2A); Movement protein (2B-MP); Coat protein ...
POL1_ARMVN RNA1 polyprotein (P1) [Cleaved into: P1A protein (1A) (Protease cofactor); Putative ATP-dependent ...

2 entries

Blackcurrant reversion association virus (BRAV)

Select_allDeselect_all
POL1_BRAV RNA1 polyprotein (P1) [Cleaved into: Protein X1; Protein X2; Putative ATP-dependent helicase (EC ...
POL2_BRAV RNA2 polyprotein (P2) [Cleaved into: Protein 2A; Movement protein (MP); Coat protein (CP)]

2 entries

Cycas necrotic stunt virus (CNSV)

Select_allDeselect_all
POL2_CNSV RNA2 polyprotein (P2) [Cleaved into: Protein 2A (P2A); Movement protein (2B-MP); Coat protein ...
POL1_CNSV RNA1 polyprotein (P1) [Cleaved into: P1A protein (1A) (Protease cofactor); Putative ATP-dependent ...

2 entries

Grapevine chrome mosaic virus (GCMV) (Hungarian grapevine chrome mosaic virus)

Select_allDeselect_all
POL1_GCMV RNA1 polyprotein (P1) [Cleaved into: P1A protein (1A) (Protease cofactor); Putative ATP-dependent ...
POL2_GCMV RNA2 polyprotein (P2) [Cleaved into: Protein 2A (P2A); Movement protein (2B-MP); Coat protein ...

2 entries

Raspberry ringspot virus (strain cherry) (RpRSV)

Select_allDeselect_all
POL1_RRVC RNA1 polyprotein (P1) [Cleaved into: P1A protein (1A) (Protease cofactor); Putative ATP-dependent ...
POL2_RRVC RNA2 polyprotein (P2) [Cleaved into: Protein 2A (P2A); Movement protein (2B-MP); Coat protein ...

2 entries

Tobacco ringspot virus (TobRV) (TRSV)

Select_allDeselect_all
CAPSD_TRSV Capsid protein (Coat protein)
POL2_TRSV RNA2 polyprotein (P2) [Cleaved into: Protein 2A (P2A); Movement protein (2B-MP); Coat protein ...

1 entry

Arabis mosaic virus (ArMV)

VP3_ARMV Protein P3

1 entry

Arabis mosaic virus (isolate Syrah) (ArMV)

POL2_ARMVS RNA2 polyprotein (P2) [Cleaved into: Protein 2A (P2A); Movement protein (2B-MP); Coat protein ...

1 entry

Grapevine fanleaf virus (isolate NW) (GFLV)

POL2_GFLVN RNA2 polyprotein (P2) [Cleaved into: Protein 2A (P2A); Movement protein (2B-MP); Coat protein ...

1 entry

Raspberry ringspot virus (strain S) (RpRSV)

POL2_RRVS RNA2 polyprotein (P2) [Cleaved into: Protein 2A (P2A); Movement protein (2B-MP); Coat protein ...

1 entry

Tobacco ringspot virus (strain Bud Blight) (TobRV) (TRSV)

POL1_TRSVB RNA1 polyprotein (P1) [Cleaved into: P1A protein (1A) (Protease cofactor); Putative ATP-dependent ...

1 entry

Tomato black ring virus (strain C) (TBRV)

VS48_TBRVC Satellite RNA 48 kDa protein

1 entry

Tomato black ring virus (strain E) (TBRV)

VS48_TBRVE Satellite RNA 48 kDa protein

1 entry

Tomato black ring virus (strain L) (TBRV)

VS48_TBRVL Satellite RNA 48 kDa protein

1 entry

Tomato black ring virus (strain MJ) (TBRV)

POL1_TBRVM RNA1 polyprotein (P1) [Cleaved into: P1A protein (1A) (protease cofactor); Putative ATP-dependent ...