Modulation of host ubiquitin pathway by viral deubiquitinase

Numerous cellular processes are regulated by the reversible conjugation of ubiquitin (UB) or ubiquitin-like (UBL) proteins to substrates. The human genome encodes several DUBs or deubiquitinating enzymes which oppose the function of E3 ligases. Several keys functions have been attributed to deubiquitinating enzymes:

- Deubiquitination can rescue proteins from degradation

- Deubiquitination can remove a non degradative signal used by cells

- Action together with E3 ligases maintain the normal intracellular pool of ubiquitin.

Several viruses encode viral deubiquitinases. One of the functions of these viral deubiquitinases is to prevent host innate response activation. For example, EBV-encoded BPLF1 interacts with and deubiquitinates TRAF6 to inhibit NF-kB signaling during viral infection. KSHV ORF64, a protein with deubiquitinase (DUB) activity, suppresses RIG-I-mediated IFN signaling by reducing the ubiquitination of RIG-I, essential for its activation. PLP2 protein from murine hepatitis virus, strongly inhibits cellular type I interferon production.

Matching UniProtKB/Swiss-Prot entries

83 entries grouped by protein (browse by keywords)

All proteins are shown (view only 80 complete proteome entries)

2 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_CCHFI
Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV) reference strain
L_DUGBA
Dugbe virus (isolate ArD44313) (DUGV) reference strain

23 entries

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

Select_allDeselect_all
LTP_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain
LTP_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LTP_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LTP_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain
LTP_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain
LTP_GAHVM
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain
LTP_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
LTP_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
LTP_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
LTP_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
LTP_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
LTP_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
LTP_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
LTP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
LTP_MHV68
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain
LTP_PSHV1
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain
LTP_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
LTP_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain
LTP_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
LTP_HCMVT
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)
LTP_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
LTP_MUHVK
Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus)
LTP_VZVO
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

1 entry

RNA replicase polyprotein (206 kDa polyprotein)

POLR_TYMV
Turnip yellow mosaic virus reference strain

25 entries

Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)

Select_allDeselect_all
R1A_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1A_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1A_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1A_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1A_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
R1A_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1A_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1A_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
R1A_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
R1A_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1A_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1A_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1A_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1A_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain
R1A_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1A_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1A_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1A_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1A_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1A_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1A_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1A_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1A_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1A_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1A_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

26 entries

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

Select_allDeselect_all
R1AB_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1AB_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1AB_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1AB_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1AB_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
R1AB_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1AB_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1AB_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
R1AB_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
R1AB_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1AB_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1AB_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1AB_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1AB_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
R1AB_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain
R1AB_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1AB_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1AB_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1AB_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1AB_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1AB_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1AB_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1AB_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1AB_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1AB_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1AB_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

6 entries

Replicase polyprotein 1ab (ORF1ab polyprotein)

Select_allDeselect_all
RPOA_EAVBU
Equine arteritis virus (strain Bucyrus) (EAV) reference strain
RPOA_PRRSB
Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV) reference strain
RPOA_PRRSL
Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain
RPOA_PRRS1
Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)
RPOA_PRRSR
Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)
RPOA_PRRSS
Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)