Closteroviridae

VIRION

Non-enveloped, flexuous and exceptionally long, filamentous particles about 950-2200 nm in length and 10-13 nm in diameter. The virion body is assembled by the major capsid protein (CP) and the tail by the minor capsid protein (CPm).

GENOME

Mono-(Ampelovirus, Closterovirus) or bi-partite (Crinivirus), linear ssRNA(+) genome of 15 to 20 kb. 3' terminus has no poly(A) tract and the 5' terminus probably has a methylated nucleotide cap.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. ORF1a and ORF1ab protein (containing RdRp) are produced by ribosomal frameshifting. Other ORFs are translated from a set of nested 3' co-terminal subgenomic RNAs.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the other viral proteins.
  7. Assembly of new virus particles.
  8. Viral movement proteins mediate virion cell-to-cell transfer.

Host-virus interaction

Suppression of RNA silencing

Citrus tristeza virus p25, p20 and p23 and Beet yellows virus p21 and function as suppressors of RNA silencing

Sweet potato chlorotic stunt virus and Tomato chlorosis virus p22 proteins also function as suppressors of RNA silencing

Matching UniProtKB/Swiss-Prot entries

31 entries grouped by protein (browse by keywords)

All proteins are shown (view only 30 complete proteome entries)

4 entries

Capsid protein (CP) (Coat protein)

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CAPSD_BYVU
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus) reference strain

Capsid protein (CP) (p22)

CAPSD_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain
CAPSD_LIYV9
Lettuce infectious yellows virus (isolate United States/92) (LIYV) reference strain
CAPSD_CTV36
Citrus tristeza virus (isolate T36) (CTV)

3 entries

Minor capsid protein (CPm)

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CPM_BYVU
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus) reference strain

Minor capsid protein (CPm) (p24)

CPM_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain
CPM_LIYV9
Lettuce infectious yellows virus (isolate United States/92) (LIYV) reference strain

1 entry

Movement protein Hsp70h (Heat shock protein 70 homolog) (Hsp70h)

MVP_LIYV9
Lettuce infectious yellows virus (isolate United States/92) (LIYV) reference strain

2 entries

Movement protein Hsp70h (Heat shock protein 70 homolog) (Hsp70h)

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MVP1_BYVU
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus) reference strain
MVP1_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain

2 entries

Movement protein p5 (5 kDa protein) (Protein P5)

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MVP2_BYVU
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus) reference strain

Movement protein p6 (6 kDa protein) (p6)

MVP2_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain

1 entry

20 kDa protein (p20)

P20_BYVU
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus) reference strain

1 entry

Protein P20A (19.6 kDa protein)

P20A_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain

1 entry

Protein P20B (19.7 kDa protein)

P20B_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain

2 entries

Protein P21 (21 kDa protein)

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P21_BYVU
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus) reference strain

RNA silencing suppressor (21 kDa protein) (p21)

P21_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain

1 entry

Protein p26

P26_LIYV9
Lettuce infectious yellows virus (isolate United States/92) (LIYV) reference strain

1 entry

RNA-binding P34 protein (P34)

P34_LIYV9
Lettuce infectious yellows virus (isolate United States/92) (LIYV) reference strain

1 entry

Protein P4 (4 kDa protein)

P4_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain

1 entry

Protein P55

P55_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain

1 entry

Protein p59

P59_LIYV9
Lettuce infectious yellows virus (isolate United States/92) (LIYV) reference strain

1 entry

Uncharacterized 6 kDa protein (p6)

P6_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain

1 entry

64 kDa protein (p64)

P64_BYVU
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus) reference strain

1 entry

Protein P7 (7 kDa protein)

P7_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain

1 entry

Protein P9

P9_LIYV9
Lettuce infectious yellows virus (isolate United States/92) (LIYV) reference strain

2 entries

Replicase polyprotein 1a

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R1A_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain

Replicase protein 1a

R1A_LIYV9
Lettuce infectious yellows virus (isolate United States/92) (LIYV) reference strain

3 entries

Replicase polyprotein 1ab

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R1AB_BYVU
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus) reference strain
R1AB_GLRV3
Grapevine leafroll-associated virus 3 (isolate United States/NY1) (GLRaV-3) (Grapevine leafroll-associated closterovirus (isolate 109)) reference strain
R1AB_LIYV9
Lettuce infectious yellows virus (isolate United States/92) (LIYV) reference strain