Flaviviridae

More on Zika virus here

VIRION

Enveloped, spherical, about 50 nm in diameter. The surface proteins are arranged in an icosahedral-like symmetry.
Source: Zhang et al

GENOME

Monopartite, linear, ssRNA(+) genome of about 9.7-12 kb. The genome 3' terminus is not polyadenylated but forms a loop structure. The 5' end has a methylated nucleotide cap (to allow translation) or a genome-linked protein (VPg).

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and the viral messenger RNA. The whole genome is translated into a polyprotein, which is processed co- and post-translationally by host and viral proteases.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral envelope protein E to host receptors mediates internalization into the host cell by clathrin-mediated endocytosis or by apoptotic mimicry
  2. Fusion of virus membrane with host endosomal membrane. RNA genome is released into the cytoplasm.
  3. The positive-sense genomic ssRNA is translated into a polyprotein, which is cleaved into all structural and non structural proteins (to yield the replication proteins).
  4. Replication takes place at the surface of endoplasmic reticulum in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Virus assembly occurs at the endoplasmic reticulum and seems to be facilitated by the viral ionic channel. The virion buds at the endoplasmic reticulum and is transported to the Golgi apparatus.
  7. Release of new virions by exocytosis.

Host-virus interaction

Adaptive immune response inhibition

Dengue NS1 protein inhibits host complement by binding C4 and reducing C4b deposition and C3 convertase activity. Through this mechanism, NS1 protects DENV from complement-dependent neutralization in solution. .

Apoptosis modulation

Flaviviruses NS3 induces apoptosis through host caspases activation .

Autophagy modulation

Flaviviruses NS4A and NS4B induces autophagy signaling .

Cell-cycle modulation

Hepatitis C virus induces down-regulation of the retinoblastoma tumor suppressor and G1/S host cell cycle checkpoint dysregulation .

Innate immune response inhibition

Hepatitis C virus inhibits the interferon signaling pathway by blocking the IFN receptors , STAT1 and TYK2 , whilst Dengue virus blocks STAT2
Hepatitis C virus inhibits the host IFN-mediated response by blocking host MAVS , TRAFs and TBK1-IKBKE-DDX3 complex , whilst pestiviruses N(pro) blocks host IRF-3 .

Host gene expression shutoff by virus

Hepatitis C virus activates PKR about 12h p.i. to shutoff host translation through the PKR-mediated phosphorylation of the eIF2alpha initiation factor .

Matching UniProtKB/Swiss-Prot entries

83 entries grouped by strain (browse by keywords)

2 entries

Hepatitis C virus genotype 1a (isolate H) (HCV) reference strain

Select_allDeselect_all
F_HCVH F protein (Alternate reading frame protein/F-protein) (ARFP/F) (Frameshifted protein) (p16) (p17)
POLG_HCVH Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Bovine viral diarrhea virus (isolate NADL) (BVDV) (Mucosal disease virus) reference strain

POLG_BVDVN Genome polyprotein [Cleaved into: N-terminal protease (N-pro) (EC 3.4.22.-) (Autoprotease p20); ...

1 entry

Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain

POLG_DEN1W Genome polyprotein [Cleaved into: Protein C (Capsid protein) (Core protein); Protein prM (Precursor ...

1 entry

Yellow fever virus (strain 17D vaccine) (YFV) reference strain

POLG_YEFV1 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Zika virus (strain Mr 766) (ZIKV) reference strain

POLG_ZIKV Genome polyprotein [Cleaved into: Protein C (Capsid protein) (Core protein); Protein prM (Precursor ...

2 entries

Hepatitis C virus genotype 1a (isolate 1) (HCV)

Select_allDeselect_all
F_HCV1 F protein (Alternate reading frame protein/F-protein) (ARFP/F) (Frameshifted protein) (p16) (p17)
POLG_HCV1 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Bovine viral diarrhea virus (strain CP7) (BVDV) (Mucosal disease virus)

POLG_BVDVC Genome polyprotein [Cleaved into: N-terminal protease (N-pro) (EC 3.4.22.-) (Autoprotease p20); ...

1 entry

Bovine viral diarrhea virus (strain SD-1) (BVDV) (Mucosal disease virus)

POLG_BVDVS Genome polyprotein [Cleaved into: N-terminal protease (N-pro) (EC 3.4.22.-) (Autoprotease p20); ...

1 entry

Classical swine fever virus (strain Alfort) (CSFV) (Hog cholera virus)

POLG_CSFVA Genome polyprotein [Cleaved into: N-terminal protease (N-pro) (EC 3.4.22.-) (Autoprotease p20); ...

1 entry

Classical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus)

POLG_CSFVB Genome polyprotein [Cleaved into: N-terminal protease (N-pro) (EC 3.4.22.-) (Autoprotease p20); ...

1 entry

Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)

POLG_DEN1B Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)

POLG_DEN1S Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)

POLG_DEN28 Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain 16681-PDK53) (DENV-2)

POLG_DEN27 Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)

POLG_DEN2J Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)

POLG_DEN2Q Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)

POLG_DEN2P Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)

POLG_DEN26 Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)

POLG_DEN2N Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 3 (strain China/80-2/1980) (DENV-3)

POLG_DEN3C Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)

POLG_DEN3M Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)

POLG_DEN3P Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)

POLG_DEN3I Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)

POLG_DEN3S Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)

POLG_DEN4D Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)

POLG_DEN4P Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)

POLG_DEN4S Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)

POLG_DEN4T Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)

POLG_DEN4H Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Hepatitis C virus genotype 1b (isolate BK) (HCV)

POLG_HCVBK Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 1b (isolate Con1) (HCV)

POLG_HCVCO Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)

POLG_HCVJ1 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)

POLG_HCVJT Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 1b (isolate HCR6) (HCV)

POLG_HCVR6 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 1b (isolate Japanese) (HCV)

POLG_HCVJA Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)

POLG_HCVTW Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 1b (strain HC-J4) (HCV)

POLG_HCVJ4 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)

POLG_HCVH9 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 1c (isolate India) (HCV)

POLG_HCVIN Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)

POLG_HCVJ6 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)

POLG_HCVJF Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)

POLG_HCVJ8 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)

POLG_HCVJP Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)

POLG_HCVBB Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 2k (isolate VAT96) (HCV)

POLG_HCVVA Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 3a (isolate NZL1) (HCV)

POLG_HCVNZ Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 3a (isolate k3a) (HCV)

POLG_HCVK3 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)

POLG_HCVTR Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 3k (isolate JK049) (HCV)

POLG_HCVJK Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 4a (isolate ED43) (HCV)

POLG_HCVED Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)

POLG_HCVEV Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 5a (isolate SA13) (HCV)

POLG_HCVSA Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 6a (isolate 6a33) (HCV)

POLG_HCV6A Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)

POLG_HCVEU Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 6b (isolate Th580) (HCV)

POLG_HCVT5 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 6d (isolate VN235) (HCV)

POLG_HCVVN Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 6g (isolate JK046) (HCV)

POLG_HCVJL Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 6h (isolate VN004) (HCV)

POLG_HCVVP Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis C virus genotype 6k (isolate VN405) (HCV)

POLG_HCVVO Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; ...

1 entry

Hepatitis GB virus B (GBV-B) (GB virus B)

POLG_GBVB Genome polyprotein [Cleaved into: Core protein; Envelope glycoprotein E1; Envelope glycoprotein E2 ...

1 entry

Japanese encephalitis virus (strain Jaoars982)

POLG_JAEVJ Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Japanese encephalitis virus (strain SA(v))

POLG_JAEV5 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Japanese encephalitis virus (strain SA-14)

POLG_JAEV1 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Kunjin virus (strain MRM61C)

POLG_KUNJM Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Langat virus (strain TP21)

POLG_LANVT Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Louping ill virus (Li)

POLG_LIV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Mosquito cell fusing agent (CFA flavivirus)

POLG_MCFA Genome polyprotein [Cleaved into: Protein C (Capsid protein) (Core protein); Small envelope protein ...

1 entry

Murray valley encephalitis virus (strain MVE-1-51) (MVEV)

POLG_MVEV5 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Tick-borne encephalitis virus (strain Hypr) (TBEV)

POLG_TBEVH Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)

POLG_TBEVW Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)

POLG_TBEVS Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)

POLG_POWVL Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

West Nile virus (WNV)

POLG_WNV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Yellow fever virus (isolate Angola/14FA/1971) (YFV)

POLG_YEFVN Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)

POLG_YEFVE Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (isolate Ivory Coast/1999) (YFV)

POLG_YEFVC Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)

POLG_YEFVI Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)

POLG_YEFVU Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)

POLG_YEFVF Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (strain Ghana/Asibi/1927) (YFV)

POLG_YEFVA Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)

POLG_YEFVT Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...