Tupavirus

VIRION

Enveloped, bullet shaped, about 140 to 160 nm long.

GENOME

Negative-stranded RNA linear genome, about 11.2 kb in size. Encodes for 7 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Matching UniProtKB/Swiss-Prot entries

7 entries grouped by protein (browse by keywords)

1 entry

Protein C

C_TUPVT
Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV) reference strain

1 entry

Glycoprotein

GLYCO_TUPVT
Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV) reference strain

1 entry

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

L_TUPVT
Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV) reference strain

1 entry

Matrix protein

MATRX_TUPVT
Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV) reference strain

1 entry

Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

NCAP_TUPVT
Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV) reference strain

1 entry

Phosphoprotein (P protein)

PHOSP_TUPVT
Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV) reference strain

1 entry

Small hydrophobic protein (Protein SH)

SH_TUPVT
Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV) reference strain