HIV-1 REV protein

NLS NES
FUNCTION
    Escorts unspliced or incompletely spliced HIV RNAs that contain a HIV Rev response element (RRE) out of the nucleus, allowing export of the viral RNA genome and late mRNAs to the cytoplasm .
INTERACTIONS
    CRM1/XPO1-RanGTP complex, Importinβ, RRE containing viral RNAs
SUBCELLULAR LOCATION
  • Host cytoplasm
  • Host nucleus
TIMING OF EXPRESSION
    Early