HIV-1 VPR protein

oligomerization
FUNCTION
Plays an essential role in the entry of the viral cDNA genome into the host nucleus during infection of quiescent cells . During virus entry, Vpr colocalizes with the capsid until the latter reaches the nucleus membrane

During virus exit, induces host cell G2 arrest possibly through degradation of host repair proteins, stopping cell division in G2-M damage checkpoint.
The lymphocytes stopped in G2-M eventually go into apoptosis , which is thought to be the main cause of AIDS disease.
INTERACTIONS
Host UNG , VPRBP (DCAF1)
SUBCELLULAR LOCATION
  • Virion
  • Host nucleus
TIMING OF EXPRESSION
    Late