Muvirus

VIRION

Non-enveloped, head-tail structure. The icosahedral head is about 54 nm with a knob-like neck. The tails is contractile, has a baseplate and 6 short fibers.

GENOME

Linear, dsDNA genome of about 40 kb, encoding for 56 proteins. 50-150 bp and about 2 Kb of bacterial DNA are respectively covalently linked at the left and the right end of Mu genome. The presence of these pieces of bacterial DNA is due to the headful packaging mechanism.

GENE EXPRESSION

Genes are transcribed by operons.

REPLICATION

CYTOPLASMIC

  1. Adsorption: the phage attaches to the target cell lipopolysaccharides (LPS) through its tail fibers. Two types of fibers are encoded by the phage to allow receptor tropism switching.
  2. Ejection of the viral DNA into host cell cytoplasm by contraction of the tail sheath.
  3. Viral DNA ends are protected from degradation by host nucleases.
  4. ?Transcription and translation of early genes?
  5. Circularization and supercoiling of the viral DNA.
  6. Integration of viral DNA into the host chromosome.
  7. Replicative transposition gives rise to 50-100 new copies of the viral genome in the host chromosome.
  8. Transcription and translation of late genes.
  9. Assembly of an empty procapsid.
  10. Momylation of viral DNA (modification of adenines) makes the packaged viral DNA resistant to host restriction enzymes.
  11. Viral tail fibers assembly and viral tail assembly.
  12. Mature virions are released from the cell by lysis.

Matching UniProtKB/Swiss-Prot entries

64 entries grouped by protein (browse by keywords)

1 entry

Late transcription activator C (C) (Gene product 21) (gp21) (Protein C)

ACTC_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Baseplate hub protein gp44 (43 kDa tail protein) (Gene product 44) (gp44) (Gene product P) (gpP)

BP44_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Baseplate puncturing device gp45 (Baseplate spike protein) (Gene product 45) (gp45) (Gene product Q) (gpQ)

BP45_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Baseplate protein gp46 (Gene product 46) (gp46) (Gene product V) (gpV)

BP46_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Baseplate protein gp47 (Gene product 47) (gp47) (Gene product W) (gpW)

BP47_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Baseplate protein gp48 (Gene product 48) (gp48) (Gene product R) (gpR)

BP48_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Major capsid protein (Gene product 34) (gp34) (Gene product T) (gpT) (Major head protein)

CAPSD_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

DNA circularization protein N (64 kDa virion protein) (Gene product 43) (gp43) (Gene product N) (gpN)

CIRCN_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

2 entries

Translational activator com (Gene product 54) (gp54) (Gene product com) (gpCom)

Select_allDeselect_all
COM_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain
COM_BPD10
Escherichia phage D108 (Bacteriophage D108)

Translational activator com (Gene product com) (gpCom)

1 entry

Uncharacterized protein gp14 (E15) (Gene product 14) (gp14)

E15_BPD10
Escherichia phage D108 (Bacteriophage D108)

1 entry

Endolysin (EC 3.2.1.17) (Gene product 22) (gp22) (Lysis protein) (Lysozyme) (Muramidase)

ENLYS_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Putative DNA ends protecting protein gam (Gene product 10) (gp10)

GAM_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

2 entries

GemA protein (Gene product 16) (gp16)

Select_allDeselect_all
GEMA_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain
GEMA_BPD10
Escherichia phage D108 (Bacteriophage D108)

1 entry

D108-specific protein (12 kDa protein)

GES_BPD10
Escherichia phage D108 (Bacteriophage D108)

2 entries

Serine recombinase gin (EC 3.1.22.-) (EC 6.5.1.-) (G-segment invertase) (Gin)

Select_allDeselect_all
GIN_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

Serine recombinase gin (EC 3.1.22.-) (EC 6.5.1.-) (G-segment invertase) (Gin) (Gene product 53) (gp53)

GIN_BPD10
Escherichia phage D108 (Bacteriophage D108)

1 entry

Uncharacterized protein gp11 (Gene product 11) (gp11)

GP11_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp12 (E13) (Gene product 12) (gp12)

GP12_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp13 (E14) (Gene product 13) (gp13)

GP13_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp14 (E15) (Gene product 14) (gp14)

GP14_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp15 (Gene product 15) (gp15)

GP15_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp18 (E18) (E18 protein) (Gene product 18)

GP18_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp19 (E19 protein) (Gene product 19) (gp19)

GP19_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp24 (Gene product 24) (gp24)

GP24_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp25 (Gene product 25) (gp25)

GP25_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp26 (Gene product 26) (gp26)

GP26_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp35 (Gene product 35) (gp35)

GP35_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Putative sheath terminator protein (Gene product 38) (gp38)

GP38_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp6 (E5) (Gene product 6) (gp6)

GP6_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp7 (E6) (Gene product 7) (gp7)

GP7_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp8 (E7) (Gene product 8) (gp8)

GP8_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp9 (E8) (Gene product 9) (gp9)

GP9_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Putative capsid assembly protein F (Gene product 30) (gp30) (Gene product F) (gpF)

GPF_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Putative capsid assembly protein G (Gene product G) (gpG)

GPG_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Gene product J (gpJ) (Gene product 36) (gp36)

GPJ_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Protein kil (Gene product 5) (gp5) (Protein cim)

KIL_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

2 entries

Adenine modification enzyme mom (Adenine acetyltransferase) (EC 2.3.1.-) (Gene product 55) (gp55) (Gene product mom) (gpMom) (Modification of Mu) (Mom)

Select_allDeselect_all
MOM_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain
MOM_BPD10
Escherichia phage D108 (Bacteriophage D108)

Adenine modification enzyme mom (Adenine acetyltransferase) (EC 2.3.1.-) (Gene product mom) (gpMom) (Modification of Mu) (Mom)

1 entry

Middle operon regulator (Mor) (GemB) (Gene product 17) (gp17)

MOR_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

2 entries

Negative regulator of transcription (Ner)

Select_allDeselect_all
NER_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

Negative regulator of transcription (Ner) (Gene product 2) (gp2)

NER_BPD10
Escherichia phage D108 (Bacteriophage D108)

1 entry

Portal protein (Gene product 29) (gp29) (Gene product H) (gpH) (Head-tail connector)

PORTL_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Protease I (Gene product 32) (gp32) (Gene product I) (gpI)

PRO_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

2 entries

Repressor c protein (Repc) (CI)

Select_allDeselect_all
REPC_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

Repressor protein c (Repc) (CI) (Gene product 1) (gp1) (Mu repressor) (MuR)

REPC_BPD10
Escherichia phage D108 (Bacteriophage D108)

1 entry

Tail fiber protein S (Gene product 49) (gp49) (Gene product S) (gpS)

S1_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Tail fiber protein S' (Gene product S') (gpS')

S2_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Probable spanin, inner membrane subunit (i-spanin) (gene product 23) (gp23)

SPAN1_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Probable tail assembly protein gp41 (Gene product 41) (gp41) (Tail assembly chaperone)

TAP_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Probable tail assembly protein FS-gp41

TAPFS_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

2 entries

ATP-dependent target DNA activator B (EC 3.6.1.3) (Gene product 04) (gp04) (Gene product B) (gpB) (MuB)

Select_allDeselect_all
TARGB_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain
TARGB_BPD10
Escherichia phage D108 (Bacteriophage D108)

ATP-dependent target DNA activator B (EC 3.6.1.3) (Gene product B) (gpB) (MuB)

1 entry

Probable terminase, large subunit gp28 (EC 3.1.-.-) (Gene product 28) (gp28) (Gene product E) (gpE) (Pacase, large subunit) (Packaging protein E)

TERL_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Probable terminase, small subunit gp27 (Gene product 27) (gp27) (Gene product D) (gpD) (Pacase, small subunit) (Packaging protein D)

TERS_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Probable tape measure protein (TMP) (Gene product 42) (gp42) (Gene product Y) (gpY)

TMP_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

DDE-recombinase A (EC 3.1.22.-) (EC 6.5.1.-) (DDE-transposase A) (Gene product 03) (gp03) (Gene product A) (gpA) (MuA)

TNPA_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Probable tail terminator protein (TrP) (Gene product 37) (gp37) (Gene product K) (gpK)

TRP_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Tail sheath protein (TSP) (Gene product 39) (gp39) (Gene product L) (gpL)

TSP_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Tail tube protein (TTP) (Gene product 40) (gp40) (Gene product M) (gpM)

TUBE_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Tail fiber assembly protein U (Gene product 50) (gp50) (Gene product U) (gpU)

U1_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Tail fiber assembly protein U' (Gene product U') (gpU')

U2_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Uncharacterized protein gp20 (Gene product 20) (gp20)

VG20_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain