Host-virus interactions of HIV proteins
The table below displays a list of the most relevant interactions between HIV and human proteins, according to the HIV virus replication cycle steps.

Life Cycle Phase Host Protein Virus Protein Presumed function of the host-virus interaction Refs. Rating
Virus Entry
Attachment CD4 gp120 (ENV) Primary receptor for HIV entry into host cell. 3
Entry CXCR4 gp120 (ENV) Co-receptor for some HIV-1 strains and primary receptor for HIV-2. 3
CCR5 gp120 (ENV) HIV-1 co-receptor. 3
Transmission CD209/DC-SIGN gp120 (ENV) Enhances transmission of virions for infection. 3
Reverse Transcription CYPA Capsid/p24 Modulates capsid structure. 3
PIN1 Capsid/p24 Modulates capsid structure. 2
Nuclear Import NUP358/RANBP2 Capsid/p24 Involved in the nuclear import of HIV PIC. 3
NUP153 Capsid/p24 Involved in the nuclear import of HIV PIC. 3
NUP98 Capsid/p24 Involved in the nuclear import of HIV PIC. 3
Importin alph3 Integrase Involved in the nuclear import of HIV PIC. 3
Importin-7 Integrase Facilitates nuclear trafficking of viral DNA genome. 3
UNG Vpr Induces proteasomal degradation of UNG. 3
DCAF1 Vpr Part of E3 ligase complex. 3
Integration LEDGF Integrase Selects sites for HIV-1 integration. 3
Transportin-3 Integrase Required for efficient HIV-1 integration. 3
UNG Integrase Prevents incorporation of dUTP in viral cDNA. 3
SMARCB1/INI1 Integrase Possibly modulates chromatin to allow efficient integration. 3
Transcription
Cyclin-T1/P-TEFb Tat Stimulates viral transcription. 3
DDX3 Tat DDX3 is required for HIV-1 Tat function. 2
NAP1 Tat Promotes viral transcription. 1
P300 Tat Tat recruits P300 to promoter and gets acetylated. 3
CBP Tat Tat recruits CBP to promoter and gets acetylated. 3
Virus Exit
Nuclear export Importin beta1 Rev Participates in Rev nuclear import. 3
ICRM1/XPO1 Rev Acts in unspliced RNAs nuclear export. 3
B23 Rev Acts in unspliced RNAs nuclear export. 3
DDX1 Rev Acts in unspliced RNAs nuclear export. 3
DDX5 Rev Acts in unspliced RNAs nuclear export. 3
Budding Tsg101 p6 Involved in HIV budding. 3
ALIX p6 Involved in HIV budding. 3
Exit Calmodulin Matrix/p17 Modulates HIV matrix protein conformation. 3
DHX9 Gag Participates in HIV-1 RNA trafficking and capsid assembly. 2
STAU1 Gag (NC domain) Acts on capsid assembly by facilitating Gag multimerization. 3
EAP30 Gag Participates in HIV-1 RNA trafficking and capsid assembly. 1
ABCE1 Gag (NC domain) Important for capsid assembly. 3
Immune Evasion
BST2 Vpu Prevents BST2 antiviral effect. 3
BTRC Vpu SCF E3 ubiquitin-protein ligase complex. 3
AP1M1 Vpu Hijacks AP-dependent trafficking pathways. 1
CD4 Vpu CD4 downregulation. 3
CD4 Nef CD4 downregulation. 3
ALIX Nef Promotes lysosomal targeting of CD4 receptor. 1
AP1M1 Nef Hijacks AP-dependent trafficking pathways. 3
AP2M1 Nef Hijacks AP-dependent trafficking pathways. 3
MHC-I Nef Disrupts MHC-I trafficking. 3
ABCA1 Nef Dysregulation of cholesterol metabolism. 2
Calnexin Nef Promotes ABCA1 activity inhibition. 1
ACOT8 Nef CD4 downregulation. 2
PACS-1 Nef Association triggers MHC-I downregulation. 3
PACS-2 Nef Association triggers MHC-I downregulation. 3
PAK2 Nef Interaction activates PAK2 to modulate actin. 3
LCK Nef CD4 downregulation. 3
HCK Nef Enhances replication potential. 3
APOBEC3G Vif Prevents hypermutations in viral DNA. 3
APOBEC3F Vif Prevents hypermutations in viral DNA. 3
ELOB Vif Part of E3 ligase complex. 3
CUL5 Vif Part of E3 ligase complex. 3
ELOC Vif Part of E3 ligase complex. 3
CBF-beta Vif Part of E3 ligase complex. 3


Putative host-virus interactions
The table below displays a list of putative HIV-host interactions and their possible functions in the virus life cycle.

Life Cycle Host Protein Virus Protein Presumed function of the host-virus interaction Ref. Rating
SAMHD1 Vpx SAMHD1 hydrolysing effect is counteracted by Vpx inhibition. 2
TRIM5alpha Capsid/p24 May inhibit retroviral replication. 3
CPSF6 Capsid/p24 Involved in the nuclear import of HIV. 2
NUP153 Integrase Involved in the nuclear import of HIV. 1
NUP62 Integrase Involved in enhancing viral DNA integration. 1
Importin alpha1 Vpr Facilitates nuclear import of Vpr. 3
SMARCB1/INI1 Tat Stimulates Tat-mediated transcription. 2
MED14 Tat Stimulates Tat-mediated transcription. 1
TIP110/SART3 Tat Enhances Tat function and transactivation of the HIV-1 LTR. 3
SP1 Tat Stimulates Tat-mediated transcription. 1
SMARCA4 Tat Binds to acetylated Tat to possibly facilitate transcription. 1
Importin beta1 Tat Mediates nuclear import of Tat. 1
DDX3 Rev Enhances Rev-mediated nuclear export. 1
SAM68/KHDRBS1 Rev Enhances Rev-mediated RNA export. 2
DDX24 Rev Interaction necessary for HIV RNA packaging. 1
RBX1 Vif Part of the Vif-Cul5 complex required for APOBEC3G degradation. 1
NFAT1 Tat Reciprocal modulatory interaction. 1
RAD23A Vpr Interaction impairs normal DNA repair function of RAD23A. 3
Catenin beta-1 Nef May modulate beta-catenin-mediated functions in T-cells. 1
GEMIN2 Integrase Seems to promote reverse transcription. 1


The HIV resource is supported by the Swiss South Africa Joint Research Programme. This page has been developed in collaboration with BioAfrica.net