Macavirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Apoptosis modulation

Alcelaphine herpesvirus 1 encodes a bcl-2 homologue that may inhibit host apoptosis.

Host splicing inhibition

Modulates the viral and host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing.

Matching UniProtKB/Swiss-Prot entries

71 entries grouped by protein (browse by keywords)

All proteins are shown (view only 70 complete proteome entries)

1 entry

Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)

AN_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Putative transcription activator BRLF1 homolog

BRLF1_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Cytoplasmic envelopment protein 1

CEP1_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Cytoplasmic envelopment protein 2

CEP2_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Cytoplasmic envelopment protein 3

CEP3_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Capsid vertex component 1

CVC1_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Capsid vertex component 2

CVC2_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Major DNA-binding protein

DNBI_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

DNA polymerase catalytic subunit (EC 2.7.7.7)

DPOL_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

DUT_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Envelope glycoprotein B (gB)

GB_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Envelope glycoprotein H (gH)

GH_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Envelope glycoprotein L (gL)

GL_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Envelope glycoprotein M (gM)

GM_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Envelope glycoprotein N

GN_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

DNA replication helicase (EC 3.6.4.-)

HELI_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Immediate-early phosphoprotein 57

IE63_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Inner tegument protein

ITP_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

2 entries

Thymidine kinase (EC 2.7.1.21)

Select_allDeselect_all
KITH_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain
KITH_AHV1W
Alcelaphine herpesvirus 1 (strain WC11) (AlHV-1) (Malignant catarrhal fever virus)

1 entry

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

LTP_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Major capsid protein (MCP)

MCP_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Nuclear egress protein 1

NEC1_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Nuclear egress protein 2

NEC2_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Portal protein

PORTL_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

DNA primase (EC 2.7.7.-)

PRIM_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)

RIR1_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

RIR2_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Capsid scaffolding protein (Capsid protein 17) (Protease precursor) (pPR)

SCAF_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Small capsomere-interacting protein

SCP_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Semaphorin-like protein A3

SEMA_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Tegument protein UL51 homolog (Uncharacterized gene 55 protein)

TEG7_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Tripartite terminase subunit 1

TRM1_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Tripartite terminase subunit 2

TRM2_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

TRM3_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Triplex capsid protein 1

TRX1_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Triplex capsid protein 2

TRX2_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Protein UL24 homolog

UL24_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Packaging protein UL32 homolog

UL32_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 66 protein

UL49_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Gene 18 protein

UL79_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 24 protein

UL87_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 30 protein

UL91_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Gene 31 protein

UL92_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Gene 34 protein

UL95_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Gene 35 protein

UL96_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

UNG_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 10 protein

VG10_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 11 protein

VG11_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 23 protein

VG23_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 27 protein

VG27_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Putative tyrosine kinase 36 (EC 2.7.10.2)

VG36_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 40 protein

VG40_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 41 protein

VG41_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 45 protein

VG45_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 48 protein

VG48_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 52 protein

VG52_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Gene 58 protein

VG58_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

DNA polymerase processivity factor

VG59_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene 73 protein

VG73_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene A1 protein

VGA1_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene A10 protein

VGA10_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized protein A2

VGA2_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene A4 protein

VGA4_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

G-protein coupled receptor A5

VGA5_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene A6 protein

VGA6_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Putative C-type lectin protein A7

VGA7_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Uncharacterized gene A8 protein

VGA8_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Putative apoptosis regulator A9

VGA9_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Probable tegument protein antigen 3

VP03_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

1 entry

Probable membrane antigen 75 (Tegument protein)

VP75_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain