Alloherpesviridae

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers. Glycoproteins complexes are embed in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of 134-248 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' non-translated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes.
  5. Transcription of early viral mRNA by host polymerase II, transport into the cytoplasm and translation into early proteins.
  6. Early proteins are involved in replication of the viral DNA and are transported back into the nucleus.
  7. Synthesis of multiple copies of viral DNA by the viral DNA-dependent DNA polymerase.
  8. Transcription of late mRNAs by host polymerase II, transport into the cytoplasm and translation into late proteins.
  9. Late proteins are structural or core proteins and are transported back into the nucleus.
  10. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Matching UniProtKB/Swiss-Prot entries

76 entries grouped by protein (browse by keywords)

1 entry

DNA polymerase (EC 2.7.7.7)

DPOL_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

DUT_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Probable ATP-dependent helicase 25 (EC 3.6.4.-)

HELI_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Thymidine kinase (EC 2.7.1.21)

KITH_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Protein kinase ORF14 (EC 2.7.11.1)

KR14_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Protein kinase ORF15 (EC 2.7.11.1)

KR15_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Protein kinase ORF16 (EC 2.7.11.1)

KR16_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Protein kinase ORF73 (EC 2.7.11.1)

KR73_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Protein kinase ORF74 (EC 2.7.11.1)

KR74_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF1

VG01_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF2

VG02_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF3

VG03_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF4

VG04_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative membrane protein ORF6

VG06_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative membrane protein ORF7

VG07_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative membrane protein ORF8

VG08_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative zinc-binding protein ORF9

VG09_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative membrane protein ORF10

VG10_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative zinc-binding protein ORF11

VG11_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative zinc-binding protein ORF12

VG12_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF13

VG13_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF17

VG17_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF18

VG18_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative membrane protein ORF19

VG19_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF20

VG20_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF21

VG21_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF22

VG22_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF23

VG23_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF24

VG24_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF26

VG26_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF27

VG27_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF28

VG28_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF29

VG29_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF30

VG30_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF31

VG31_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF32

VG32_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF33

VG33_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF34

VG34_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF35

VG35_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF36

VG36_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF37

VG37_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF38

VG38_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF39

VG39_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF40

VG40_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF41

VG41_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF42

VG42_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF43

VG43_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF44

VG44_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF45

VG45_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Probable major glycoprotein

VG46_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Subtilisin-like protease (EC 3.4.21.-)

VG47_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF48

VG48_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF50

VG50_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative membrane protein ORF51

VG51_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF52

VG52_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF53

VG53_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF54

VG54_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF55

VG55_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF56

VG56_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative membrane protein ORF59

VG59_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF60

VG60_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF61

VG61_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF63

VG63_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF64

VG64_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF65

VG65_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF66

VG66_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF67

VG67_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF68

VG68_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF70

VG70_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF72

VG72_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF75

VG75_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF76

VG76_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF77

VG77_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Putative zinc-binding protein ORF78

VG78_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Uncharacterized protein ORF79

VG79_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

1 entry

Probable DNA-packaging protein (Terminase)

VTER_ICHVA
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain