Atadenovirus

VIRION

Non-enveloped capsid with a pseudo T=25 icosahedral symmetry. The capsid diameter is about 90 nm. The capsid shell consists of 720 hexon subunits arranged as 240 trimers and 12 vertex penton capsomers each with a fiber protruding from the surface.

GENOME

Non-segmented, linear double-stranded DNA of 30 kb encoding about 30 proteins. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly). All genes are transcribed by host RNA pol II. Genes transcribed by RNA pol II give rise to multiple mRNA that are produced by alternative splicing and use of different poly(A) sites.

REPLICATION

NUCLEUS

  1. Attachment of the viral fiber glycoproteins to host receptors mediates endocytosis of the virus into the host cell and fiber shedding.
  2. Disruption of the endosome by lytic protein VI releases the viral capsid in the cytosol.
  3. Viral penetration into host nucleus.
  4. Transcription of early genes (E genes) by host RNA pol II, replication of the DNA genome by DNA strand displacement in the nucleus.
  5. Transcription of late genes (L genes) by host RNA pol II, mostly encoding for structural proteins.
  6. Assembly of new virions in the nucleus.
  7. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

33 entries grouped by protein (browse by keywords)

All proteins are shown (view only 32 complete proteome entries)

1 entry

Protein 105R

105R_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Putative protein 22K

22K_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Putative protein 33K

33K_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa)

CAP3_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Pre-protein VI (pVI)

CAP6_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII)

CAP8_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Hexon protein (CP-H) (Protein II)

CAPSH_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Penton protein (CP-P) (Penton base protein) (Protein III)

CAPSP_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)

DNB2_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

DNA polymerase (EC 2.7.7.7)

DPOL_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Protein E4.1

E41_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Protein E4.2

E42_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Protein E4.3

E43_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Late L2 mu core protein (Protein X) (pX) (pMu)

L2MU_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Protein LH1

LH1_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Protein LH2

LH2_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

2 entries

Hexon-interlacing protein LH3

Select_allDeselect_all
LH3_ADEO7
Ovine adenovirus D serotype 7 (isolate OAV287) (OAdV-7) (Ovine adenovirus 7) reference strain
LH3_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII)

NP_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Protein ORF1

ORF1_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

2 entries

Structural protein p32K

Select_allDeselect_all
P32K_ADEO7
Ovine adenovirus D serotype 7 (isolate OAV287) (OAdV-7) (Ovine adenovirus 7) reference strain
P32K_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Packaging protein 1 (Packaging protein IVa2)

PKG1_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)

PKG3_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

4 entries

Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

Select_allDeselect_all
PRO_ADEB4
Bovine adenovirus 4 (BAdV-4) reference strain
PRO_ADEO7
Ovine adenovirus D serotype 7 (isolate OAV287) (OAdV-7) (Ovine adenovirus 7) reference strain
PRO_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain
PRO_ADEB7
Bovine adenovirus 7 (BAdV-7)

1 entry

Protein RH1

RH1_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)

SHUT_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Fiber protein (SPIKE) (Protein IV)

SPIKE_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein)

TERM_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain

1 entry

Probable U-exon protein

UXP_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain