Avibirnavirus

VIRION

Non enveloped, single-shelled T=13 icosahedral symmetry capsid of about 70 nm in diameter, composed of 260 trimers of VP2 that form spikes projecting radially from the capsid. The peptides derived from pre-VP2 C-terminal cleavages remain associated within virion. VP3 forms a ribonucleoprotein complex with the genomic RNA. Minor amounts of VP1 are also incorporated in the virion.

GENOME

Segmented linear dsRNA genome: 2 segments (A,B) encode for 5 proteins. VP1 is found in a free form and covalently attached at the 5' genomic RNA end (VPg). Segments size is about 2.9-3 kb. Genome total size is about 6 kb.

GENE EXPRESSION

Genomic segment A encodes for a structural polyprotein which is matured in cis by VP4. It also encodes an alternative ORF (VP5) translated possibly by leaky scanning Genomic segment B encodes for VP1.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the cytoplasm.
  2. Transcription of the dsRNA genome by viral polymerase occurs inside the virion, so that dsRNA is never exposed to the cytoplasm. This plus-strand transcript is used as template for translation.
  3. (+)RNAs are encapsidated in virion particle, inside which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  4. Mature virions are released by budding.

Host-virus interaction

Host transcription modulation

Apoptosis modulation

Infectious bursal disease virus (IBDV) destroys its target cells, the B-lymphocytes precursors, by inducing caspases activation and apoptosis. VP5 seems to be the major apoptosis inducer through its interaction with the voltage-dependent anion channel 2 (VDAC2) .

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by protein (browse by keywords)

All proteins are shown (view only 6 complete proteome entries)

9 entries

Structural polyprotein (PP)

Select_allDeselect_all
POLS_IBDVU
Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus) reference strain
POLS_IBDV
Avian infectious bursal disease virus (IBDV) (Gumboro disease virus)
POLS_IBDV5
Avian infectious bursal disease virus (strain 52/70) (IBDV) (Gumboro disease virus)
POLS_IBDVA
Avian infectious bursal disease virus (strain Australian 002-73) (IBDV) (Gumboro disease virus)
POLS_IBDVB
Avian infectious bursal disease virus (strain Chicken/Cuba/Soroa/1998) (IBDV) (Gumboro disease virus)
POLS_IBDVC
Avian infectious bursal disease virus (strain Cu-1) (IBDV) (Gumboro disease virus)
POLS_IBDVE
Avian infectious bursal disease virus (strain E) (IBDV) (Gumboro disease virus)
POLS_IBDVO
Avian infectious bursal disease virus (strain OH) (IBDV) (Gumboro disease virus)
POLS_IBDVS
Avian infectious bursal disease virus (strain STC) (IBDV) (Gumboro disease virus)

4 entries

RNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)

Select_allDeselect_all
RDRP_IBDVU
Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus) reference strain
RDRP_IBDV
Avian infectious bursal disease virus (IBDV) (Gumboro disease virus)
RDRP_IBDVA
Avian infectious bursal disease virus (strain Australian 002-73) (IBDV) (Gumboro disease virus)
RDRP_IBDVB
Avian infectious bursal disease virus (strain Chicken/Cuba/Soroa/1998) (IBDV) (Gumboro disease virus)

5 entries

Protein VP5

Select_allDeselect_all
VP5_IBDVU
Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus) reference strain
VP5_IBDV5
Avian infectious bursal disease virus (strain 52/70) (IBDV) (Gumboro disease virus)
VP5_IBDVB
Avian infectious bursal disease virus (strain Chicken/Cuba/Soroa/1998) (IBDV) (Gumboro disease virus)
VP5_IBDVC
Avian infectious bursal disease virus (strain Cu-1) (IBDV) (Gumboro disease virus)
VP5_IBDVS
Avian infectious bursal disease virus (strain STC) (IBDV) (Gumboro disease virus)