Ranavirus

VIRION

Polyhedral virions 120-350 nm in diameter. The capsid displays an icosahedral symmetry T=133 or 147, with an internal lipid membrane. Virions are either externally enveloped or not depending whether they budded from the cell membrane, or were arranged in paracrystaline array in the host cell cytoplasm and were released by lysis.

GENOME

Linear, dsDNA genome of 150-170 kb. The genome contains terminal and redundant sequences. Encodes for about 100 proteins.
Approximately 25% of the cytosine residues of the genome are methylated by a virus encoded DNA methyltransferase. However, there is at least one ranavirus, Singapore grouper iridovirus (SGIV), that lacks the DNA methyltransferase gene and cannot methylate its DNA.

GENE EXPRESSION

REPLICATION

NUCLEO-CYTOPLASMIC

  1. Attachement of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the DNA core into the host cytoplasm.
  3. Viral DNA is transported to the cell nucleus where host macromolecular synthesis is rapidly shutdown. Transcription is initiated by virally modified host RNA polymerase II.
  4. Parental DNA is used to produce genome and greater than genome length DNA.
  5. Progeny DNA is transported into cytoplasmic viral factories where large concatamers of viral DNA are formed by recombination. Transcription of very late transcripts may also take place in the cytoplasm.
  6. Assembly of new virions in the cytoplasm.
  7. Virions exit the cell by budding or cell lysis.

Host-virus interaction

Apoptosis modulation

The grouper iridovirus (GIV) contains an antiapoptotic B-cell lymphoma (Bcl)-2-like gene that inhibits host apoptosis.

Matching UniProtKB/Swiss-Prot entries

99 entries grouped by protein (browse by keywords)

All proteins are shown (view only 98 complete proteome entries)

1 entry

Putative transcription factor 001R

001R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 002L

002L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 3R

003R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 004R

004R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 005R

005R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 006R

006R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 007R

007R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative helicase 009L (EC 3.6.4.-)

009L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 010R

010R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 011R

011R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 012L

012L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 013R

013R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 014R

014R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 015R

015R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 017L

017L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 018L

018L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative serine/threonine-protein kinase 019R (EC 2.7.11.1)

019R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 020R

020R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 021L

021L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 023R

023R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 024R

024R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 027R

027R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 028R

028R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 029L

029L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 030R

030R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 031R

031R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 032R

032R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Transmembrane protein 033R

033R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 034R

034R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 035L

035L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 036L

036L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

uncharacterized protein 037R

037R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 039R

039R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 040R

040R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 041R

041R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 042L

042L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 043R

043R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 044R

044R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 045L

045L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 046L

046L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 047L

047L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 048L

048L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative SAP domain-containing protein 049L

049L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 050L

050L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 051R

051R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 052L

052L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative myristoylated protein 053R

053R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 054L

054L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative helicase 055L (EC 3.6.4.-)

055L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 055R

055R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 056R

056R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative phosphotransferase 057R

057R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 058R

058R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 059L

059L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 061L

061L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Caspase recruitment domain-containing protein 064R

064R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative collagen-like domain-containing protein 065L

065L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 066L

066L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative uncharacterized protein 068R

068R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Transmembrane protein 069R

069R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 070R

070R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 071R

071R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 072L

072L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 073L

073L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 074L

074L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 075L

075L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 076R

076R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

LCDV1 orf2-like protein

077L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 078L

078L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 079R

079R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative transcription elongation factor S-II-like protein 81R

081R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 084R

084R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 086L

086L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 087L

087L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative FAD-linked sulfhydryl oxidase 088R (EC 1.8.3.2)

088R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 89R

089R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 092R

092R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 093L

093L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 094L

094L_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative RAD2-like endonuclease 095R (EC 3.1.-.-)

095R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 096R

096R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 097R

097R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Uncharacterized protein 098R

098R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative deoxynucleoside kinase (EC 2.7.1.-)

DNK_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative DNA (cytosine-5)-methyltransferase (EC 2.1.1.37)

DNMT_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative DNA polymerase 060R (EC 2.7.7.7)

DPOL_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23)

DUT_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Immediate-early protein ICP-18

ICP18_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Immediate-early protein ICP-46

ICP46_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

2 entries

Major capsid protein (MCP) (P50)

Select_allDeselect_all
MCP_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain
MCP_RTRV
Rana tigrina ranavirus

1 entry

Putative helicase 022R (EC 3.6.4.-)

O22R_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase large subunit)

RIR1_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative ribonucleoside-diphosphate reductase small subunit 067L (EC 1.17.4.1)

RIR2_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III)

RNC_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative DNA-directed RNA polymerase 008R (EC 2.7.7.6)

RPB1_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Putative DNA-directed RNA polymerase II subunit RPB2 homolog (EC 2.7.7.6)

RPB2_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Integrase homolog

VINT_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain

1 entry

Early 31 kDa protein (P31K)

VP31_FRG3G
Frog virus 3 (isolate Goorha) (FV-3) reference strain