Alphapolyomavirus

VIRION

Non-enveloped capsid with a T=7d icosahedral symmetry, about 50 nm in diameter.

GENOME

Circular dsDNA about 5 kb in size, associated with cellular histones in a chromatin-like complex. Encodes for 5-6 proteins.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly/exit). 5-6 proteins are expressed from the two pre-MRNA by alternative splicing. All genes are transcribed by host RNA pol II.

REPLICATION

NUCLEAR

  1. Attachement of the viral proteins to host receptors triggers lipid-mediated endocytosis of the virus into the host cell.
  2. Virion transits through endoplasmic reticulum where host protein disulfide isomerases rearrange its capsid structure
  3. Export of misfolded virion to the cytoplasm possibly through host ERAD pathway
  4. Loss of VP1 in the low-calcium conditions of the cytosol
  5. Import of genomic DNA into host nucleus.
  6. Transcription of early genes (LT and sT genes)
  7. Replication of the DNA genome in the nucleus.
  8. Transcription of late genes encoding for structural proteins (VP1, VP2 and VP3).
  9. Assembly of new virions in nuclear viral factories.
  10. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

21 entries grouped by protein (browse by keywords)

All proteins are shown (view only 18 complete proteome entries)

4 entries

Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

Select_allDeselect_all
LT_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain
LT_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
LT_POVM3
Murine polyomavirus (strain 3) (MPyV)
LT_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)

4 entries

Middle T antigen (MT) (MT-AG)

Select_allDeselect_all
MT_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain
MT_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
MT_POVM3
Murine polyomavirus (strain 3) (MPyV)
MT_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)

4 entries

Small t antigen (ST) (ST-AG)

Select_allDeselect_all
ST_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain
ST_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
ST_POVM3
Murine polyomavirus (strain 3) (MPyV)
ST_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)

5 entries

Major capsid protein VP1 (Major structural protein VP1)

Select_allDeselect_all
VP1_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
VP1_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1)
VP1_POVM3
Murine polyomavirus (strain 3) (MPyV)
VP1_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)
VP1_POVMP
Murine polyomavirus (strain P16 small-plaque) (MPyV)

Capsid protein VP1

4 entries

Minor capsid protein VP2 (Minor structural protein VP2)

Select_allDeselect_all
VP2_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain
VP2_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
VP2_POVM3
Murine polyomavirus (strain 3) (MPyV)
VP2_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)