Aquareovirus

VIRION

Non enveloped, icosahedral virion with a double capsid structure, about 75 nm in diameter. Pentameric turrets sit on the outside of the innermost capsid. The outer capsid has a T=13 icosahedral symmetry, the inner capsid a T=2* icosahedral symmetry.

GENOME

Segmented linear dsRNA genome. Contains 11 segments coding for 12 proteins. Segments size range from 0.8 to 4.0 kb. Genome total size range from 18.2 to 30.5 kb.

GENE EXPRESSION

The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response of dsRNA. Viral polymerase synthesizes mRNA from each dsRNA segment which are translocated to the cell cytoplasm where they are translated.

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors probably mediates endocytosis of virus into host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

27 entries grouped by protein (browse by keywords)

All proteins are shown (view only 24 complete proteome entries)

3 entries

Major inner capsid protein VP3 (EC 3.6.4.13) (ATP-dependent DNA helicase VP3)

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CAPSD_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
CAPSD_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain
CAPSD_AQRVA
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)

3 entries

RNA-directed RNA polymerase VP2 (EC 2.7.7.48)

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RDRP_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
RDRP_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain
RDRP_AQRVA
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)

2 entries

Non-structural protein 1 (NS1)

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VNS1_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VNS1_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Non-structural protein 1 (NS1) (NS73)

2 entries

Non-structural protein 2 (NS2)

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VNS2_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VNS2_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

2 entries

Non-structural 3 (NS3) (NS26)

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VNS3_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain

Non-structural protein 3 (NS3)

VNS3_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

2 entries

Non-structural protein 4 (NS4)

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VNS4_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VNS4_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Non-structural protein 4 (NS4) (NS31)

2 entries

Non-structural protein 5 (NS5)

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VNS5_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VNS5_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Non-structural protein 5 (NS5) (NS16)

3 entries

Outer capsid protein VP1

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VP1_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VP1_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain
VP1_AQRVA
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)

2 entries

Outer capsid protein VP4

Select_allDeselect_all
VP4_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VP4_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

2 entries

Microtubule-associated protein VP5

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VP5_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VP5_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

2 entries

Clamp protein VP6

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VP6_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VP6_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

2 entries

Outer capsid protein VP7

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VP7_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VP7_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain