Fijivirus

VIRION

Non enveloped, icosahedral virion with a double capsid structure, about 65-70 nm in diameter. Pentameric turrets sit on the outside of the innermost capsid. The outer capsid has a T=13 icosahedral symmetry, the inner capsid a T=2* icosahedral symmetry.

GENOME

Segmented linear dsRNA genome. Contains 10 segments coding for 12 proteins. Segments size range from 1.4 to 4.5 kb. Genome total size is about 27-30 kb.

GENE EXPRESSION

The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response to dsRNA. The viral polymerase synthesizes a capped mRNA from each dsRNA segment. This capped mRNA is translocated to the cell cytoplasm where it is translated.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

15 entries grouped by protein (browse by keywords)

All proteins are shown (view only 12 complete proteome entries)

1 entry

Putative major capsid protein

CAPSD_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

RNA-directed RNA polymerase VP1 (EC 2.7.7.48)

RDRP_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

2 entries

Protein S10

Select_allDeselect_all
VP10_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

Putative outer capsid protein p10

VP10_RBSDV
Rice black streaked dwarf virus (RBSDV)

1 entry

Putative structural protein VP3

VP3_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Uncharacterized protein VP4

VP4_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Uncharacterized protein VP5

VP5_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Uncharacterized protein VP6

VP6_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Probable non-structural 41.0 kDa protein

VP61_MRDV
Maize rough dwarf virus (MRDV)

1 entry

Probable non-structural 36.3 kDa protein

VP62_MRDV
Maize rough dwarf virus (MRDV)

1 entry

Uncharacterized protein VP7-1

VP71_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Uncharacterized protein VP7-2

VP72_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Microtubule-associated protein VP8

VP8_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Non-structural protein P9-1

VP91_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Uncharacterized protein VP9-2

VP92_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain