Rubivirus

VIRION

Enveloped, spherical, icosahedral, 65-70nm in diameter, capsid with a T=4 icosahedral symmetry made of 240 monomers. The envelope contains 80 trimer spikes, each spike = 3 x E1/E2 heterodimers.

GENOME

Monopartite, linear, ssRNA(+) genome of 9.7 kb. The genome is capped and polyadenylated.

GENE EXPRESSION

The virion RNA is infectious and serves as both genome and viral messenger RNA. The whole genome is translated in a non-structural polyprotein which is processed by host and viral proteases. Structural polyprotein is expressed through a subgenomic mRNA.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral E glycoprotein to host receptors mediates clathrin-mediated endocytosis of virus into the host cell.
  2. Fusion of virus membrane with host endosomal membrane. RNA genome is released into the cytoplasm.
  3. The positive-sense genomic ssRNA is translated into a polyprotein, which is cleaved into non-structural proteins necessary for RNA synthesis (replication and transcription).
  4. Replication takes place in cytoplasmic viral factories at the surface of endosomes. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the subgenomic RNA (sgRNA) gives rise to the structural proteins.
  7. Capsid assembly occurs in cytoplasm.
  8. The capsid is envelopped by budding at the plasma membrane where the virion exits the cell.

Host-virus interaction

Host gene expression shutoff by virus

Rubella virus capsid protein (Rubivirus) seems to mediate host translation shutoff by inhibiting host poly(A)-binding protein. .

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by protein (browse by keywords)

9 entries

Non-structural polyprotein p200 (p200)

Select_allDeselect_all
POLN_RUBVT
Rubella virus (strain Therien) (RUBV) reference strain
POLN_RUBVB
Rubella virus (strain BRD1) (RUBV)
POLN_RUBVC
Rubella virus (strain BRDII) (RUBV)
POLN_RUBVD
Rubella virus (strain Cendehill) (RUBV)
POLN_RUBVM
Rubella virus (strain M33) (RUBV)
POLN_RUBVN
Rubella virus (strain RN-UK86) (RUBV)
POLN_RUBVO
Rubella virus (strain TO-336 vaccine) (RUBV)
POLN_RUBVR
Rubella virus (strain RA27/3 vaccine) (RUBV)
POLN_RUBVV
Rubella virus (strain TO-336) (RUBV)

9 entries

Structural polyprotein (p110)

Select_allDeselect_all
POLS_RUBVT
Rubella virus (strain Therien) (RUBV) reference strain
POLS_RUBVB
Rubella virus (strain BRD1) (RUBV)
POLS_RUBVC
Rubella virus (strain BRDII) (RUBV)
POLS_RUBVD
Rubella virus (strain Cendehill) (RUBV)
POLS_RUBVM
Rubella virus (strain M33) (RUBV)
POLS_RUBVN
Rubella virus (strain RN-UK86) (RUBV)
POLS_RUBVO
Rubella virus (strain TO-336 vaccine) (RUBV)
POLS_RUBVR
Rubella virus (strain RA27/3 vaccine) (RUBV)
POLS_RUBVV
Rubella virus (strain TO-336) (RUBV)