Alpharetrovirus

VIRION

Enveloped, spherical to pleomorphic in shape, 80-100 nm in diameter.

GENOME

Monopartite, linear, dimeric, ssRNA(+) genome of about 7.2 kb, with a 5'-cap and a 3’poly-A tail. There are two long terminal repeats (LTRs) of about 600nt long at the 5' and 3' ends. The LTRs contain the U3, R, and U5 regions. There are also a primer binding site (PBS) at the 5’end and a polypurine tract (PPT) at the 3’end.

GENE EXPRESSION

The integrated provirus utilizes the promoter elements in the 5' LTR to drive transcription. This gives rise to the unspliced full length mRNA that will serve as genomic RNA to be packaged into virions or used as a template for translation of gag(pro) and gag(pro)-pol (1 ribosomal frameshift) polyproteins. The spliced mRNA encodes env that is cleaved into SU and TM envelope proteins. There are no additional genes other than gag, pro, pol and env.

REPLICATION

NUCLEAR

  1. Virus attaches to host receptors through the SU glycoprotein. TM glycoprotein mediates fusion with cell membrane.
  2. Internalization and partial uncoating.
  3. ssRNA(+) genome is copied into a linear dsDNA molecule by the reverse transcriptase.
  4. Nuclear entry of the viral dsDNA when the nuclear membrane is disassembled at mitosis.
  5. Viral dsDNA is covalently and randomly integrated into the cell’s genome by the viral integrase (=provirus).
  6. Transcription of provirus by Pol II produces viral spliced and unspliced RNAs.
  7. Nuclear export of the incompletely spliced RNAs.
  8. Translation of unspliced viral RNAs produces Env, Gag and Gag-Pol polyproteins.
  9. Assembly of the virion at the host cellular membrane and packaging of the viral RNA genome.
  10. Budding through the plasma membrane and release of the virions.
  11. Proteolytic processing of the precursors polyproteins by viral protease and maturation of the virions.

Matching UniProtKB/Swiss-Prot entries

47 entries grouped by protein (browse by keywords)

All proteins are shown (view only 17 complete proteome entries)

2 entries

Envelope glycoprotein gp95 (Env polyprotein)

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ENV_RSVSA
Avian leukosis virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A)) reference strain
ENV_RSVP
Rous sarcoma virus (strain Prague C) (RSV-PrC)

3 entries

Tyrosine-protein kinase transforming protein erbB (EC 2.7.10.1)

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ERBB_ALV
Avian leukosis virus (ALV)
ERBB_AVIER
Avian erythroblastosis virus (strain ES4)
ERBB_AVIEU
Avian erythroblastosis virus (strain ts167)

1 entry

p55-v-Fos-transforming protein

FOS_AVINK
Avian retrovirus NK24

2 entries

Tyrosine-protein kinase transforming protein Fps (EC 2.7.10.2)

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FPS_AVISP
Avian sarcoma virus (strain PRCII)
FPS_FUJSV
Fujinami sarcoma virus

8 entries

Gag-Pro polyprotein

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GAG_RSVSA
Avian leukosis virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A)) reference strain
GAG_AVIMA
Avian myeloblastosis associated virus (MAV)

Proteinase p15 (EC 3.4.23.-)

GAG_AVIMC
Avian myelocytomatosis virus MC29

Gag polyprotein

GAG_AVISU
UR2 sarcoma virus (UR2SV) (Avian sarcoma virus (strain UR2))

Core protein p19 (Gag protein p19)

GAG_AVISY
Avian sarcoma virus (strain Y73)

Gag-yes polyprotein

GAG_FUJSV
Fujinami sarcoma virus

Gag polyprotein

GAG_RSVP
Rous sarcoma virus (strain Prague C) (RSV-PrC)
GAG_RSVSB
Rous sarcoma virus (strain Schmidt-Ruppin B) (RSV-SRB)

1 entry

P47(GAG-CRK) protein

GAGC_AVISC
Avian sarcoma virus (strain CT10)

1 entry

Viral jun-transforming protein (v-Jun)

JUN_AVIS1
Avian sarcoma virus (strain 17)

1 entry

Transforming protein Maf

MAF_AVIS4
Avian musculoaponeurotic fibrosarcoma virus AS42

1 entry

Serine/threonine-protein kinase-transforming protein mil (EC 2.7.11.1)

MIL_AVIMH
Avian retrovirus MH2

1 entry

Transforming protein Myb

MYB_AVIMB
Avian myeloblastosis virus

5 entries

Viral myc transforming protein (v-Myc)

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MYC_AVIM2
Avian myelocytomatosis virus CMII
MYC_AVIMC
Avian myelocytomatosis virus MC29
MYC_AVIME
Avian retrovirus MH2E21
MYC_AVIMH
Avian retrovirus MH2
MYC_AVIOK
Avian retrovirus OK10

4 entries

Gag-Pro-Pol polyprotein

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POL_RSVSA
Avian leukosis virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A)) reference strain
POL_ALV
Avian leukosis virus (ALV)

Pol polyprotein

POL_RSVP
Rous sarcoma virus (strain Prague C) (RSV-PrC)
POL_RSVSB
Rous sarcoma virus (strain Schmidt-Ruppin B) (RSV-SRB)

1 entry

Transforming protein Qin (Oncogene Qin)

QIN_AVIS3
Avian sarcoma virus (strain 31) (ASV31)

2 entries

Serine/threonine-protein kinase-transforming protein Rmil (EC 2.7.11.1)

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RMIL_AVEVR
Avian rous-associated virus type 1
RMIL_AVII1
Avian retrovirus IC10

1 entry

Tyrosine-protein kinase transforming protein ros (EC 2.7.10.1)

ROS_AVISU
UR2 sarcoma virus (UR2SV) (Avian sarcoma virus (strain UR2))

1 entry

Tyrosine-protein kinase transforming protein RYK (EC 2.7.10.1)

RYK_AVIR3
Avian retrovirus RPL30

1 entry

Tyrosine-protein kinase transforming protein SEA (EC 2.7.10.2)

SEA_AVIET
Avian erythroblastosis virus (strain S13)

1 entry

Transforming protein Ski

SKI_AVIES
Avian erythroblastosis virus (strain Sloan-Kettering)

9 entries

Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src)

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SRC_AVIS2
Avian sarcoma virus (strain PR2257)
SRC_AVISR
Avian sarcoma virus (strain rASV1441)
SRC_AVISS
Avian sarcoma virus (strain S1)
SRC_AVIST
Avian sarcoma virus (strain S2)
SRC_RSVH1
Rous sarcoma virus (strain H-19)
SRC_RSVP
Rous sarcoma virus (strain Prague C) (RSV-PrC)
SRC_RSVPA
Rous sarcoma virus (strain PA101T)
SRC_RSVSA
Avian leukosis virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A))
SRC_RSVSE
Rous sarcoma virus (strain Schmidt-Ruppin E) (RSV-SR-E)

1 entry

Putative trans-acting factor

VP14_RSVSA
Avian leukosis virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A)) reference strain